Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats

Omidi, Ghazaleh; Karimi, Seyed Asaad; Rezvani-Kamran, Arezoo; Monsef, Alireza; Shahidi, Siamak; Komaki‬, Alireza

doi:10.1007/s11011-019-00402-7

Cited by 21 publications

(14 citation statements)

References 51 publications

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“…The training session was done according to the previous procedure conducted in our laboratory (37,39,40). In summary, training session was consisted of one block of 4 trails per day for four consecutive days.…”

Section: Hidden Platform Trainingmentioning

confidence: 99%

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

Moridi

Sarihi

Habibitabar

et al. 2020

Preprint

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Background High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the effects of post-training administration of mGluR2/3 antagonism; LY341495 on spatial memory in rats fed with HFD by using Morris Water Maze (MWM) task. Intraperitoneal injection (i.p) injection of LY341495 was done 30 minutes before retention test. Results Our results showed that HFD did not have any effect on memory acquisition. There were not significant differences in escape latency and swimming distance between experimental groups (P>0.05, Two-way ANOVA). Our finding showed that consumption of an HFD leads to spatial memory impairment. There were significant differences in time spent in target zone between experimental groups [F (3, 20) = 7.031, P=0.0021, one-way ANOVA]. Also, LY341495 improved HFD-induced reference memory impairment. HFD animals treated with LY341495 spent more time in the target zone in compare with HFD animals (P= 0.0449). Conclusions Our results suggested that prolonged consumption of high-fat diet has no effects on the acquisition of spatial learning, but can impair memory retention of the adult male rats and post-training administration of LY341495 can improve HFD-induced reference memory impairment.

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Section: Hidden Platform Trainingmentioning

confidence: 99%

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

Moridi

Sarihi

Habibitabar

et al. 2020

Preprint

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“…STZ (Sigma, St. Louis, MO, USA), which was dissolved in freshly prepared 0.05 M citrate buffer (pH 4.5) immediately before injection [18,19]. Blood glucose concentrations were monitored once per week.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

The effects of Commiphora mukul extract on spermatogenesis and testosterone levels in male diabetic rats

Rezaei

Salehi

Karimi

et al. 2020

Clin Exp Reprod Med

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Objective:The strong antioxidant activity of Commiphora mukul prompted us to conduct the present study to explore whether treatment with C. mukul extract (CME) would have any protective influence on sperm parameters, testosterone levels, and plasma glucose levels in streptozotocin (STZ)-induced diabetic rats. Methods: Male Wistar rats were randomly divided into four groups: control, control animals treated with CME, diabetic animals, and diabetic animals treated with CME. CME extract (300 mg/kg) was administered for 60 days by daily gavage. Diabetes was induced by an intraperitoneal injection of 50 mg/kg STZ. The epididymal sperm count, weight, motility, morphology, viability, and serum testosterone and glucose levels were determined. Results: In the diabetic animals, CME decreased blood glucose levels (p< 0.05), increased the total sperm count (p< 0.05), and decreased the proportion of sperm with abnormal morphology (p< 0.05). Diabetes reduced sperm motility (p< 0.001), and CME supplementation partially reversed this effect of diabetes (p= 0.003). Furthermore, in diabetic animals, CME decreased the proportion of immotile sperm (p< 0.001). In rats, diabetes caused a significant decrease (p< 0.05) in serum testosterone levels (F[3, 28] = 3.283, p= 0.035), but treatment of diabetic animals with CME increased serum testosterone levels. Conclusion:The present study demonstrated that C. mukul possesses proandrogenic activity and exerts a beneficial effect on sperm parameters in diabetic rats. This is an Open Access article distributed under the terms of the Creative Commons AttributionNon-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.eCERM.org AA Rezaei et al. Effect of Commiphora mukul on spermatogenesis in diabetic rats

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“…Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) and pelargonidin were purchased from Sigma-Aldrich (St Louis, MO, USA). Aβ 25-35 was aggregated by incubation in 37°C for 4 days and solubilized in sterile water at 1 µg/µL concentration and stored at -20°C.…”

Section: Chemicalsmentioning

confidence: 99%

“…In this study, 28 male Wistar rats (250 -300 g, 12 weeks) were obtained from the animal center of Hamadan University of Medical Sciences (Hamadan, Iran). Animals were randomly divided into 4 groups (7 rats in each group): (1) control (intact) group, (2) sham-operated group, (3) Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) lesioned animals (5µg), and (4) pelargonidin-treated Aβ groups.…”

Section: Experimental Design and Animals' Classificationmentioning

confidence: 99%

Pelargonidin exhibits restoring effects against amyloid β-induced deficits in the hippocampus of male rats

Asl

Bergen

Ashtari

et al. 2019

Med. J. Islam. Republ. Iran

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Background: Alzheimer's disease (AD) is characterized by amyloid-beta plaques, neuronal loss, and cognitive dysfunction. Oxidative stress plays a key role in the pathophysiology of AD, and it has been suggested that antioxidants may slow the progress of the disease. In this study, the possible protective effects of pelargonidin (a natural flavonoid) against amyloid β (Aβ)-induced behavioral deficits was investigated in rats. Methods: Adult Wistar male rats were treated with intrahippocampal injections of the Aβ (aa 25-35) and intraperitoneal injection of pelargonidin. Learning and spatial memory were tested using the Morris water maze (MWM) task. The antioxidant activity was evaluated using the ferric reducing/antioxidant power assay (FRAP assay). Data were analyzed using SPSS 20, and value of p≤0.05 was considered significant. Results: The results of this study showed that Aβ significantly increased escape latency and the distance traveled in the MWM, and pelargonidin attenuated these behavioral changes. Aβ induced a significant decrease in the total thiol content of hippocampus, and pelargonidin restored the hippocampal antioxidant capacity. Conclusion: The results of this study suggest that pelargonidin can improve Aβ-induced behavioral changes in rats.

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Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats

Cited by 21 publications

References 51 publications

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

The effects of Commiphora mukul extract on spermatogenesis and testosterone levels in male diabetic rats

Pelargonidin exhibits restoring effects against amyloid β-induced deficits in the hippocampus of male rats

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