Effect of coexposure to 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assay

Verheyen, Geert R.; Pauwels, G.; Verschaeve, Luc; Schoeters, Greet

doi:10.1002/bem.10100

Cited by 31 publications

(27 citation statements)

References 22 publications

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“…In the latter, Ding et al (2003) found that a 5 mT, 60 Hz magnetic field significantly increased CREST (Calcinosis, Raynaud's phenomenon, Esophageal dismotility, Sclerodactility, Telangectasia)-positive micronuclei in CHO cells after exposure to X-rays. Verheyen et al (2003) detected a significant increase of micronuclei (without distinguishing between CREST-positive and -negative) in human lymphocytes exposed to vinblastine and 80 or 800 mT. Mailhes et al (1997), instead, found an increase in hyperploidy in murine oocytes.…”

Section: Introductionmentioning

confidence: 92%

“…On the other hand, other works have detected positive results only in conditions of co-exposure with other mutagenic agents, such as static magnetic fields (Tofani et al 1995, benzopyrene (Cho & Chung 2003, Moretti et al 2005, X-rays (Ding et al 2003) and vinblastine (Verheyen et al 2003). These results led to the hypothesis that ELF magnetic fields are able to enhance, but not to start, a mutagenic event.…”

Section: Introductionmentioning

confidence: 98%

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Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Udroiu

Cristaldi

Ieradi

et al. 2006

International Journal of Radiation Biology

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Purpose: To detect possible clastogenic and aneugenic properties of a 50 Hz, 650 mT magnetic field. Materials and methods: The micronucleus test with CREST (Calcinosis, Raynaud's phenomenon, Esophageal dismotility, Sclerodactility, Telangectasia) antibody staining was performed on liver and peripheral blood sampled from newborn mice exposed to an ELF (Extremely Low Frequency) magnetic field during the whole intra-uterine life (21 days), and on bone marrow and peripheral blood sampled from adult mice exposed to the same magnetic field for the same period. Results: Data obtained in newborn mice show a significant increase in micronuclei frequencies. In absolute terms, most of the induced micronuclei were CREST-negative (i.e., formed by a chromosome fragment). However, in relative terms, ELF exposure caused a two-fold increase in CREST-negative micronuclei and a four-fold increase in CREST-positive micronuclei (i.e., formed by a whole chromosome). No significant effect was recorded on exposed adults. Conclusions: These findings suggest the need for investigation of aneugenic properties of ELF magnetic fields in order to establish a possible relationship to carcinogenesis.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Udroiu

Cristaldi

Ieradi

et al. 2006

International Journal of Radiation Biology

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“…Magnetic water were induced a significant increase in Hb in lambs, ewes and in fish [44][45][46]. Treatment with magnetic water caused a high potential in the processing of the body's cells and tissues of different nutrition appropriate to perform its best of its biological, leading to the lifting capacity of organs and tissues hematopoietic like liver, kidney and spleen, to produce blood [4,33,47]. Also due to increase in metabolic reactions in the tissues, raising hormone which works to increase the production of RBC and thus increases PCV [4,48,49].…”

Section: Effect Of Magnetic Water On Haematological Parametersmentioning

confidence: 99%

Biological Effects of Magnetic Water on Human and Animals

Ebrahim¹

2017

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Abstract:The aim of the present study was to investigate the beneficial effects of magnetized water for human and animals. There was an improvement in water quality when exposed to the magnetic field with considerable change in the pH, total dissolved solids, total hardness, conductivity, salinity, dissolved oxygen, evaporating temperature, minerals, organic matter and total count of bacteria. Therefore it's penetration into cell wall would be facilitated which can accelerate ordinary diffusion of water that is vital for growth of different organs. Patients uses magnetic water for digestive, urinary and nervous problems, ailments like mastitis, pains and swellings, painful urination and many other disorders. Magnetized water has been found effective in alleviating colds, coughs, bronchitis, all types of fever and more, arthritis pain, reducing blood pressure, recovering quickly from a stroke, and it helpful in the regularization of women's menses. Also, treatment with magnetic water was very effective in breaking up kidney and gall bladder stones into small particles. The water also prevented further formation of stones in the kidneys and gallbladder. Magnetic water may prevent aging and fatigue by increasing the cell membrane permeability. Effectiveness of magnetized water in the prevention and treatment of atherosclerosis has been shown in some animal and human studies. It has been reported that magnetic water help unclog the arteries and veins of deposits of cholesterol and salts and normalize the circulatory system. Also, magnetized water can be helpful in weight control, as an adjutant to a correct diet because this water improves metabolic activity, it may be helpful in burning up excessive fatty tissue. Magnetized drinking water improves nutrient digestibility, saves water consumption, optimizing rumen fermentation parameters, and it could an effective way to reduce methane production and contributing to mitigate environmental impact in livestock, positive animal health, which is reflected in the increase in milk yield and its component and improves blood picture and antioxidant status. Magnetized drinking water caused increase milk production, mutton, and wool in sheep not only that, but more weight gain in geese and egg production and hatchability in turkey can be achieved, and increasing in milk yields in dairy cows and ewes. It can be concluded that magnetic water treatment improved blood picture, biochemical parameters, semen quality, and antioxidant status in human and animals. So, magnetic water must be used to mitigate the harmful effects of drugs, toxins, and environmental pollutant on human and animals.

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“…A replication study is not completely terminated but as far as we can tell at present the results appear to be largely identical. It should be realized yet that ELF-MF's-induced micronuclei (possibly due to aneuploidy) were not found in one of our earlier studies [24] as well as in some other investigations [19]. An explanation may be that cells that are not in optimal condition are more susceptible to ELF-MF-induced genetic alterations.…”

Section: Discussionmentioning

confidence: 48%

“…Effects were for example found when ELF's were used as cofactors that modify cellular responses to other agents, e.g. static fields [21], benzopyrene [22], benzene [23], vinblastine [24,25], and X-rays [25]. According to these studies ELF-magnetic fields are thus able to enhance, but not to start a mutagenic (DNA damaging) effect.…”

Section: Introductionmentioning

confidence: 98%

On the Alleged Association Between Extremely Low Frequency Magnetic Field Exposures and an Increased Risk of Alzheimer’s Disease

Maes¹,

Anthonissen²,

Verschaeve³

2016

RadJ

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Abstract. There are a few publications in scientific journals suggesting that persons who are regularly exposed to ELF-magnetic fields (occupational, but also residential exposures) may be at risk for contracting Alzheimer's disease. It should be noted that these reports are only pointing to a possible association but do not at present provide any proof of association. We have performed a number of preliminary in vitro laboratory investigations to explore the plausibility of such an association. Our investigations were based on similarities found in cells from Alzheimer disease patients and in cells exposed to extreme low frequency magnetic fields. We especially investigated genetic damage in C3A and SH-SY5Y cells exposed in vitro to 50 Hz magnetic fields (0-500 µT) using the cytome assay. We found an increased frequency of large micronuclei (suggesting a possible aneugenic effect) and increased frequency of nuclear buds (suggesting gene amplification). In this, our results may show some similarities with the observed micronuclei in blood and buccal cells of Alzheimer disease patients. The effects were found in both cell lines and were previously observed for exposure levels as low as 10 µT. This is however in contrast with earlier results obtained in human lymphocytes where no induction of micronuclei was found using the same exposure unit. The results thus need to be confirmed and further analyses need to be done.

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Effect of coexposure to 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assay

Cited by 31 publications

References 22 publications

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Biological Effects of Magnetic Water on Human and Animals

On the Alleged Association Between Extremely Low Frequency Magnetic Field Exposures and an Increased Risk of Alzheimer’s Disease

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