Effect of cohesive interparticle force on the flow characteristics of granular material

Forsyth, Anthony; Hutton, S. Raymond; Rhodes, Martin

doi:10.1016/s0032-5910(02)00046-3

Cited by 61 publications

(41 citation statements)

References 5 publications

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“…Higher values of both parameters for the spray-dried CNF powder than for the MCCs indicated poorer flow properties of the CNF than the MCCs. At relatively high humidity, van der Waals forces between small particles are higher than between larger particles causing poorer flowability of powders consisted of small particles (22,23). However, it seems that the uniform spherical particle shape of the CNF particles (Fig.…”

Section: Flow Propertiesmentioning

confidence: 98%

Spray-Dried Cellulose Nanofibers as Novel Tablet Excipient

et al. 2011

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Abstract. The purpose of this study was to evaluate the potential of cellulose nanofibers (also referred as microfibrillated cellulose, nanocellulose, nanofibrillated, or nanofibrillar cellulose) as novel tabletting material. For this purpose, physical and mechanical properties of spray-dried cellulose nanofibers (CNF) were examined, and results were compared to those of two commercial grades of microcrystalline cellulose (MCC), Avicel PH101 and Avicel PH102, which are the most commonly and widely used direct compression excipients. Chemically, MCC and CNF are almost identical, but their physical characteristics, like mechanical properties and surface-to-volume ratio, differ remarkably. The novel material was characterized with respect to bulk and tapped as well as true density, moisture content, and flow properties. Tablets made of CNF powder and its mixtures with MCC with or without paracetamol as model compound were produced by direct compression and after wet granulation. The tensile strength of the tablets made in a series of applied pressures was determined, and yield pressure values were calculated from the measurements. With CNF, both wet granulation and direct compression were successful. During tablet compression, CNF particles were less prone to permanent deformation and had less pronounced ductile characteristics. Disintegration and dissolution studies showed slightly faster drug release from direct compression tablets with CNF, while wet granulated systems did not have any significant difference.

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Section: Flow Propertiesmentioning

confidence: 98%

Spray-Dried Cellulose Nanofibers as Novel Tablet Excipient

et al. 2011

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“…Atomic force microscopy analysis for (a) uncoated and (b) alumina-coated silica nanoparticles. Ramirez-Aguilar et al, 1999;Portigliatti et al, 2000;Eve et al, 2002;Forsyth et al, 2002;Andersson and Bergstrom, 2005). In the reported studies, micron-sized particles were physically attached to the tip of an AFM cantilever using techniques such as micro-manipulators and diverse types of adhesive materials.…”

Section: Direct Measurement Of Interaction Forcesmentioning

confidence: 99%

Modification of interparticle forces for nanoparticles using atomic layer deposition

Hakim

Blackson

Weimer

2007

Chemical Engineering Science

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“…Basically, the magnitude of van der Waals interparticle forces becomes considerably small compared to the hydrodynamic forces (HDFs) for particles in excess of 100 lm in size [22,23]. Accordingly, in order to use van der Waals forces to study the behavior of the bed in the presence of IPFs, it is required to utilize particles smaller than 100 lm in size.…”

Section: Introductionmentioning

confidence: 99%