Effect of Coitus on Chlorpromazine Inhibition of Ovulation in the Rat1

Coital and Estrogen Signals: A Contrast in the Preovulatory Neuroendocrine Networks of Rabbits and Rhesus Monkeys1

“…Indeed, coitus-induced ovulation in women has been suggested [11], although Quadri et al [12] found no fluctuations in serum LH levels in cycling rhesus monkeys after coitus. It is well established that rodent species release LH and ovulate in response to genital stimulation after drug-, steroid-, or photo-blockade [13][14][15]. Thus occurrence of both spontaneous and induced ovulation is common in mammalian species, although a single type of evoking stimulus is usually predominant.…”

Response of Hypothalamic Units to Stimulation of the Vaginal Cervix: Specific Versus Non-Specific Effects

“…Appreciable evidence even suggests that stimulation of these regions during coitus may precipitate the release of luteinizing hormone (LH) in those animals which have previously been regarded as spontaneous ovulators. The rat, for example, ovulates to coitus after the spontaneous event has been inhibited by continuous illumination (Dempsey & Searles, 1943) or pharmacological agents such as chlorpromazine (Harrington, Eggert, Wilbur & Linkenheimer, 1966) and pentobarbitone (Everett, 1967). Also, Taleisnik, Caligaris & Astrada (1966) found a dramatic rise in the level of serum LH in the rat within minutes of mating.…”

Effect of Prostaglandin F2α upon Ovulation and LH, FSH and Prolactin Secretion in Chlorpromazine Blocked Rats

“…It is well known that the inhibitory effects of CPZ on the ovulation are especially apparent at "the critical period" on the day of proestrus in the rat (Barralough and Sawyer, 1957;Harrington et al, 1966;Harrington et al, 1967;Yamazaki and Nakayama, 1972;Yamazaki, 1972) . It is also reported that the CPZ-blocked ovulation can be overcome by the subcutaneous injection of LH or HCG and estrogens or progestins (Harrington et al, 1966;Harrington et al, 1967;Yamazaki and Nakayama, 1972;Yamazaki, 1972).…”

“…It is also reported that the CPZ-blocked ovulation can be overcome by the subcutaneous injection of LH or HCG and estrogens or progestins (Harrington et al, 1966;Harrington et al, 1967;Yamazaki and Nakayama, 1972;Yamazaki, 1972).…”