Effect of combination of Bromelain and Quercetin extracted from pineapples and fenugreek in mice induced arthritis

Abstract

This study revealed that bromelain from pineapple and quercetin from fenugreek mixture were active in reducing the effect of arthritis the body diameter measurements within day 4 until the day 10 of peak of induction of arthritis reached the maximum at 5.8 for CRP (mm/hr) ESR (mg/Dl) and reduced it to nearly the normal value 4.3 for CRP and 1.9 for ESR at day 30 with concentration 350 mg/kg of (bro, quer) and within day 4 until the day 10 of peak of induction of arthritis reached the maximum at 2.8 mm of paw volume and reduced it to nearly the normal value 2.9 for 300 mg/kg of (bro, quer) and 2.6 for 350 mg/kg (bro, quer) at day 30 with concentration 350 mg/kg , While within day 0 until the day 10 of peak of induction of arthritis reached the maximum at 83 ng/dl for IgG2 and 70 ng/dl for IgG1 and 40 IgG reduced it to nearly the normal value 68 ng/dl of IgG2 for 350 mg/kg of (bro, quer) and 57ng/dl of IgG1 and 39 ng/dl of IgG for 350 mg/kg (bro, quer) at day 30 with concentration 350 mg/kg .Also within day 0 until the day 10 of peak of induction of arthritis reached the lowest body weight at 18 mg of paw volume and increasing it to nearly the normal weight 19mg for 300 mg/kg of (bro,quer) and 21 mg for 350 mg/kg (bro, quer) at day 30 with concentration.