Effect of combination therapy of melatonin and orlistat on high fat diet induced changes in lipid profiles and liver function parameters in serum of rats

Sivakumar, Appa Iyer; Mohanam, Lavanya; Alwin, D; Venkataraman, P.

doi:10.1016/j.obmed.2016.05.003

Cited by 19 publications

(14 citation statements)

References 28 publications

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“…The observation of the current study was in accordance with those of the previous studies [21,22]which reported that there is an elevation of both triglycerides and NEFA in NAFLD in rats. The mechanisms governing the accumulation of TGs in hepatic cells include changes in hepatocellular metabolism, [23,24] propagating an imbalance between uptake and de novo fatty acid synthesis, VLDL formation and subsequent export, and oxidation capacity [25].The present study also revealed that treatment with omega-3 fatty acid showed significant reduction in the level of triglycerides and NEFA in plasma compared to those of HFD treated group. This is in agreement with the previous [26,27]which supports the triglyceride-lowering properties of omega-3 fatty acid and decreased NEFA level in plasma.…”

Section: Discussion:-supporting

confidence: 66%

Omega-3 Fatty Acid Improve Non Alcoholic Fatty Liver Induced by High Fat Diet in Rats.

Hashem¹,

Rashed²,

Safwat³

et al. 2017

IJAR

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Section: Discussion:-supporting

confidence: 66%

Omega-3 Fatty Acid Improve Non Alcoholic Fatty Liver Induced by High Fat Diet in Rats.

Hashem¹,

Rashed²,

Safwat³

et al. 2017

IJAR

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“…Various factors are considered responsible for this unavoidable condition of hyperleptinemia [45]; likewise, different conventional drugs are being used for its management including inhibitor of pancreatic lipase, like orlistat. This drug may act to decrease the body weight by reducing the absorption of fat [46]. However, few adverse effects like, liver toxicity and steatorrhea has been reported with this drug.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation

et al. 2020

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Leptin resistance and co-existing insulin resistance is considered as hallmark of dietinduced obesity. Here, we investigated therapeutic potential of hesperidin to improve leptin and insulin resistance using high fat diet (HFD)-induced obese experimental animal model. We also performed in silico studies to validate therapeutic effectiveness of hesperidin by performing protein-ligand docking and molecular dynamics simulation studies. Group 1 was identified as control group receiving vehicle only. Group 2 was marked as non-treated group receiving 60% HFD. While, other groups were treated daily with orlistat (120 mg/kg/d), hesperidin (55 mg/kg/d), combination of hesperidin (55 mg/kg/d) + orlistat (120 mg/kg/d). Hesperidin alone (P<0.001) and particularly in combination with orlistat (P<0.001), resulted in controlling the levels of HFD-altered biomarkers including random and fasting state of glycemia, leptin and insulin resistance. Similarly, hesperidin also improved the serum and tissue levels of leptin, interleukin-6 and tumor necrosis factor-alpha more significantly (P<0.05) when compared with that of orlistat. These results were found to be in accordance with the results of histopathological examination of pancreas, liver and adipose tissues. In-silico studies also proved that hesperidin binds to leptin receptor with higher affinity as compared to that of orlistat and induces the favorable variations in geometrical conformation of leptin receptor to promote its association with leptin which may lead to the cascades of reactions culminating the lipolysis of fats that may ultimately lead to cure obesity. The results of this study may be a significant expectation among the forthcoming treatment strategies for leptin and insulin resistance.

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“…Specifically, obesity and type 2 diabetes are associated with an increase in oxidative stress and inflammation in adipose tissues [2,9,10]. Consequently, researchers have been exploring functional materials of plant origin that contain antioxidants to combat obesity and its comorbidities, as alternatives to conventional approaches that have been adopted previously-including surgery and anti-obesity drugs, which do not often have enduring effects and have side effects including headaches, excessive thirst, insomnia, constipation, and steatorrhea [11], or may have yo-yo effects [8,12]. Therefore, the consideration of antioxidants as therapeutic agents in the treatment and/or prevention of obesity and its comorbidities would be insightful.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade

Ojulari

Lee

Nam

2020

IJMS

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Present-day lifestyles associated with high calorie-fat intake and accumulation, as well as energy imbalance, have led to the development of obesity and its comorbidities, which have emerged as some of the major health issues globally. To combat the disease, many studies have reported the anti-obesity effects of natural compounds in foods, with some advantages over chemical treatments. Carotenoids, such as xanthophyll derived from seaweeds, have attracted the attention of researchers due to their notable biological activities, which are associated mainly with their antioxidant properties. Their involvement in oxidative stress modulation, the regulation of major transcription factors and enzymes, and their antagonistic effects on various obesity parameters have been examined in both in vitro and in vivo studies. The present review is a collation of published research over the last decade on the antioxidant properties of seaweed xanthophyll carotenoids, with a focus on fucoxanthin and astaxanthin and their mechanisms of action in obesity prevention and treatment.

show abstract

Effect of combination therapy of melatonin and orlistat on high fat diet induced changes in lipid profiles and liver function parameters in serum of rats

Cited by 19 publications

References 28 publications

Omega-3 Fatty Acid Improve Non Alcoholic Fatty Liver Induced by High Fat Diet in Rats.

Omega-3 Fatty Acid Improve Non Alcoholic Fatty Liver Induced by High Fat Diet in Rats.

Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation

Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade

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