Effect of combined oral contraceptives on orthodontic tooth movement in a female rat model

Yu, Jing-Hong; Zhou, Y; Zhang, Tao; Lv, Jialing; Firth, Fiona; Zhao, Xin; Xu, Xizhen; Li, Mei

doi:10.21307/aoj-2020-041

Cited by 1 publication

(4 citation statements)

References 39 publications

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“…Significantly less OIIRR was reported in animals with a chronic combined oral contraceptive, baicalin intake, sites with previous bone ceramic or bio osseous graft, systemic sodium fluoride, immature roots, osteopontin (OPN) deficiency, angiogenic cytokines, high caffeine, ovariectomy, and orchiectomy rats ( 91 , 97 , 2 , 120 , 102 , 123 , 124 , 105 , 125 , 127 ).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-eight articles were included for data extraction, 1 on mice ( 91 ) and 27 on three different types of rats (Wister, Sprague-Dawley, and Fischer-344) ( 92 , 93 , 113 , 114 , 115 , 95 , 116 , 117 , 97 , 118 , 10 , 119 , 2 , 120 , 102 , 121 , 122 , 123 , 124 , 105 , 125 , 106 , 126 , 128 , 108 , 109 , 127 ). All articles were published between 2003 and 2021.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of secondary outcomes, 19 studies reported histological and/or biological findings ( 93 , 114 , 95 , 91 , 118 , 10 , 119 , 2 , 120 , 102 , 121 , 122 , 105 , 125 , 106 , 126 , 127 ). The summaries of the included studies are listed in Supplementary Table 11 .…”

Section: Resultsmentioning

confidence: 99%

“…Oral contraceptive intake, on the other hand, decreases the severity of OIIRR due to the effect on the hormonal level that affects periodontal tissue and cementum metabolism ( 102 , 127 ) suggests that assessment of individual bone metabolism pre-orthodontic treatment may give insight into the rate and severity of OIIRR ( 108 ).…”

Section: Discussionmentioning

confidence: 99%

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Under pressure—mechanisms and risk factors for orthodontically induced inflammatory root resorption: a systematic review

Dawood

Kroeger

Chavda

et al. 2023

European Journal of Orthodontics

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Summary Background The application of orthodontic forces causes root resorption of variable severity with potentially severe clinical ramifications. Objective To systematically review reports on the pathophysiological mechanisms of orthodontically induced inflammatory root resorption (OIIRR) and the associated risk factors based on in vitro, experimental, and in vivo studies. Search methods We undertook an electronic search of four databases and a separate hand-search. Selection criteria Studies reporting on the effect of orthodontic forces with/without the addition of potential risk factors on OIIRR, including (1) gene expression in in-vitro studies, the incidence root resorption in (2) animal studies, and (3) human studies. Data collection and analysis Potential hits underwent a two-step selection, data extraction, quality assessment, and systematic appraisal performed by duplicate examiners. Results One hundred and eighteen articles met the eligibility criteria. Studies varied considerably in methodology, reporting of results, and variable risk of bias judgements. In summary, the variable evidence identified supports the notion that the application of orthodontic forces leads to (1) characteristic alterations of molecular expression profiles in vitro, (2) an increased rate of OIIRR in animal models, as well as (3) in human studies. Importantly, the additional presence of risk factors such as malocclusion, previous trauma, and medications like corticosteroids increased the severity of OIIRR, whilst other factors decreased its severity, including oral contraceptives, baicalin, and high caffeine. Conclusions Based on the systematically reviewed evidence, OIIRR seems to be an inevitable consequence of the application of orthodontic forces—with different risk factors modifying its severity. Our review has identified several molecular mechanisms that can help explain this link between orthodontic forces and OIIRR. Nevertheless, it must be noted that the available eligible literature was in part significantly confounded by bias and was characterized by substantial methodological heterogeneity, suggesting that the results of this systematic review should be interpreted with caution. Registration PROSPERO (CRD42021243431).

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