Effect of concentrated growth factors on frequency of alveolar Osteitis following partially-erupted mandibular third molar surgery: a randomized controlled clinical study

Abstract

Background: The aim of this prospective study was to assess the effectiveness of concentrated growth factors (CGF) in preventing the development of alveolar osteitis (AO) after the extraction of partially-erupted mandibular third molars. Methods: Seventy patients (26 men and 44 women) 18 years or older (mean age 25.86; range 18-35) underwent 140 third molar extractions. All the patients presented with bilateral, partially-erupted mandibular third molars and underwent surgical extractions. In each case, one socket received CGF and the other served as a control. The predictor variable was the CGF application and the sides were categorized as 'CGF' and 'non-CGF'. The outcome variable was the development of AO during the first postoperative week. Other study variables included age and gender. Data were analyzed using Cochran's Q test with the significance level set at a P value less than 0.05. Results: The overall frequency of AO was 11.4% for the control group. The frequency of AO in the CGF group was significantly lower than in the non-CGF group (p < 0.001). Conclusions: Based on the results of this study, application of CGF fibrin gel may decrease the risk of AO development after mandibular third molar surgery. Trial registration: This study was registered in ClinicalTrials.gov database on November 1, 2019 (ID: NCT04151147, retrospectively registered).

Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized controlled clinical study

“…In the area of dentistry, (CGF) has several applications, including the dentin–pulp complex regeneration [ 48 ], defects of periodontium [ 37 ], alveolar osteitis treatment [ 27 ], ridge augmentation surgeries, recession coverage, sinus lift, cystectomy, mixed with autologous bone graft and also used as a membrane during dental implantation, etc [ 21 , 24 ].…”

“…They have been selected based on the following criteria: (1) Had symmetrically, bilaterally, horizontal or vertical completely impacted lower third molars with comparable hardness grade that was assessed based on Pederson's description [ 26 ] using panoramic radiographs (the difficulty index ranged from 7 to 10), (2) Age ranged from 18 to 38 years, (3) Good oral hygiene, (4) Cooperative patients who able to complete the follow up appointments, (5) No previous history of systemic diseases, (6) No periodontal diseases, especially in the work area, (7) No history of long term steroid therapy, and (8) No history of radiotherapy in the head and neck region. All the patients were informed about the treatment protocol and the purpose of the study, and patients had undergone surgical extraction of bilateral impacted lower third molars in a single appointment [ 27 ].…”

Alveolar ridge preservation in post-extraction sockets using concentrated growth factors: a split-mouth, randomized, controlled clinical trial

“…The patients were selected based on the following criteria: (a) age ≥18; (b) patients with completely impacted lower third molars ( Figure 1A ) that are symmetrically, bilaterally, horizontally, or vertically positioned with a difficulty index ranging from 7 to 10 based on Pederson’s description ( 19 ) in need of surgical extraction; (c) no pericoronitis or periapical lesions; (d) patients who are cooperative and able to attend the follow-up visits; (e) neither a history of systemic diseases nor the use of systemic drugs. All of the patients had been notified of the treatment plan and the study’s objectives, and they had undertaken surgical extraction of both of their impacted lower third molars in a single visit ( 12 , 20 ).…”

Alternativas de Tratamiento para la Osteítis Alveolar

“…Todos estos en conjunto aligeran el crecimiento de tejido de granulación fibrovascular. 25,26,32 Muchas investigaciones han demostrado que la aplicación de CGF en la extracción dental estimula la regeneración de tejidos blandos y óseos, promoviendo el desarrollo y migración celular, así como regulando el comportamiento natural de múltiples células y apoyando a la angiogénesis, ayudando de esta manera a reducir significativamente el dolor e inflamación. 25,26 Protocolo de preparación de CGF…”