Effect of Concentration on the Clinical Pharmacology of Corticosteroid Ointment Formulations

The skin blanching assay with halcinonide, influence of halcinonide concentration and application time ⋆

“…However, our findings agree fairly well with earlier and more reeent findings of others. In the reports of Gibson et al [8,[13][14], various dilutions of the same active ingredient were tested in 1, 3, 5 and 6 h application protocols. Formulations were compared in single visual reading experiments and in multiple reading experiments.…”

“…Since bioavailability of the product on the application site without occlusion is difficult to control [18], we preferred an occluded application. Further dilution of the active ingredient was not considered, that might have led to inhomogeneity in the formu]ation and to analytical problems due to the greatly reduced amounts of active substance [8]. As a consequence, we selected a protocol with application under occlusion during 2 h on]y.…”

“…Several authors reported significant colour differenees after application of corticosteroid formulations of different potency groups, using instrumental skin colour quantification methods [4][5][6]. • Gibson et al [8] give an overview of the literature concerning the impact of changes in concentration on the performance of corticosteroid formulations. However, the results of the summarized experiments are not homogeneous: some authors noticed a clear concentration-response relationship after dilution of active ingredients while others did not detect any.…”

Effect of topical corticosteroid application frequency on histamine‐induced wheals

“…The pharmacology of corticosteroids has been discussed in details by Schimmer & Parker 2 . Frequency of application of topical corticosteroids is an important variable affecting the efficacy of a corticosteroid preparation 3 . Twice‐daily application of topical corticosteroids is generally accepted as the standard frequency of topical cortcosteroid application 4…”