2013
DOI: 10.1177/1534735413485417
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Effect of Conjugated Linoleic Acid Supplementation on Inflammatory Factors and Matrix Metalloproteinase Enzymes in Rectal Cancer Patients Undergoing Chemoradiotherapy

Abstract: Objectives. The aims of this study were to determine the effect of conjugated linoleic acid (CLA) supplementation on inflammatory factors and matrix metalloproteinase (MMP) enzymes in rectal cancer patients undergoing chemoradiothetrapy. Method and Material. In this randomized, double-blind, placebo-controlled pilot study, 34 volunteer patients with rectal cancer undergoing chemoradiotherapy assigned into the CLA group (n = 16), receiving 3 g CLA/d, and placebo group (n = 18) receiving placebo capsules (sunflo… Show more

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Cited by 58 publications
(37 citation statements)
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References 49 publications
(88 reference statements)
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“…These natural compounds entail relatively low cost and elicit non-toxic effects; these compounds are also physiologically bioavailable and have multiple molecular targets in cancer chemoprevention [4], [23]. Natural products have been extensively investigated in the prevention or intervention of tumorigenesis and neoplastic progression in early stages prior to the onset of invasive malignant diseases [28]. However, several effective cancer chemotherapeutic drugs, such as doxorubicin and cisplatin, exhibit major drawbacks, including drug resistance and systemic toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…These natural compounds entail relatively low cost and elicit non-toxic effects; these compounds are also physiologically bioavailable and have multiple molecular targets in cancer chemoprevention [4], [23]. Natural products have been extensively investigated in the prevention or intervention of tumorigenesis and neoplastic progression in early stages prior to the onset of invasive malignant diseases [28]. However, several effective cancer chemotherapeutic drugs, such as doxorubicin and cisplatin, exhibit major drawbacks, including drug resistance and systemic toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to cow and goat, sheep cheese had a lower thrombogenic index and intermediate concentrations of SFA, MUFA and PUFA (Table 1). Saturated FA are known to increase the risk of coronary heart disease (CHD; Williams et al, 2000), on the contrary, milk MUFA and PUFA (e.g., C18:2 c9, t11) can reduce the risk of CHD and prevent some types of cancer (Mohammadzadeh et al, 2013). However, there is a lack of scientific evidence that other SFA such as C4:0-C10:0 (short-and medium-chain FA; SMFA) have an effect on blood cholesterol and CHD risk (Astrup et al, 2011).…”
Section: Nutritional Value Of Total Lipids In Cheesesmentioning
confidence: 99%
“…However, in healthy subjects, CLA (3g/day for 12 weeks; 50:50 blend of c9,t11 and 22 t10,c12 isomers) increased plasma IgA and IgM but also decreased pro-inflammatory 23 cytokines, TNF-α and IL-1β and increased the concentrations of the anti-inflammatory 24 cytokine, IL-10 [295]. Further, in patients with rectal cancer undergoing chemoradiotherapy, 25 3 g/d CLA (50:50 blend of c9,t11 and t10,c12 isomers) for 6 weeks (1 week before and 5 26 weeks after chemoradiotherapy) reduced plasma TNF-α, IL-1β, IL-6, hsCRP, MMP-9 and 27 MMP-2 concentrations [333]. 28…”
Section: Are All Trans-polyunsaturated Fatty Acids Equal?mentioning
confidence: 92%