Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility

Abstract

The aim of the present study was to observe the adverse effects of high level of reactive oxygen species (ROS) in idiopathic male infertility and the role of a combined antioxidant therapy for six months to overcome the detrimental effects of ROS. A prospective study including 185 infertile male was conducted at Institute of Reproductive Medicine (IRM) from January 2014 to April 2015. All the major sperm parameters as well as ROS, antioxidant level and the effect of high ROS level were evaluated before and after the therapy. A significant improvement in sperm motility and concentration were observed after 6 months of therapy. Antioxidant level had increased and ROS level had decreased significantly after the antioxidant treatment. Improvement in morphology and leukocyte concentration were observed though not clinically significant. Conclusion This combined antioxidant therapy may improve sperm quality after continuous 6 months of treatment. However, further study is needed regarding this experiment for validating the trend. How to cite this article Chattopadhyay R, Yasmin S, Chakravarty BN. Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility. Int J Infertil Fetal Med 2016;7(1):1-6.

Role of Dietary Antioxidant Supplements in Male Infertility: A Review

“…Filipcikova et al in their study included 44 infertile men who were supplemented with lycopene for 3 months and found that seminal plasma's AA/DHA ratio improved in these cases [ 23 ]. Another study done by Chattopadhyay et al in 2016 showed an increase in motility and sperm count with a lowering of reactive oxygen species level, which gives a positive effect of Co Q10 on the participating patients [ 24 ]. Supplementation of omega-3 reduced DNA fragmentation, improved total antioxidant capacity (TAC) concentrations, and enhanced sperm motility as per studies done by Juan Carlos Martinex Soto et al and Gonzalez Ravina et al respectively [ 25 , 26 ].…”