Effect of continuous ingestion of a beverage prepared with Lactobacillus gasseri CP2305 inactivated by heat treatment on the regulation of intestinal function

Sawada, Daisuke; Sugawara, Toshitaka; Ishida, Yu; Aihara, Kohtaro; Aoki, Yusuke; Tanaka, Isao; Takano, Kazuhiko; Fujiwara, Shigeru

doi:10.1016/j.foodres.2015.11.032

Cited by 75 publications

(52 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1998 R&D report of the Calpis Co., Ltd.; Sawada et al . ). The European Food Safety Authority includes L. gasseri in the list of species with a Qualified Presumption of Safety.…”

Section: Methodsmentioning

confidence: 97%

“…This strain shows an antiflatulent effect, especially in constipated volunteers, and a 40% colonization rate in the digestive tracts of healthy volunteers after three-time oral administration at a dose of 1 9 10 11 CFU (ref. 1998 R&D report of the Calpis Co., Ltd.; Sawada et al 2016). The European Food Safety Authority includes L. gasseri in the list of species with a Qualified Presumption of Safety.…”

Section: Probioticsmentioning

confidence: 99%

“…CP2305 showed a 40% chance of colonizing the digestive tracts of volunteers (Sawada et al . ). In the present study, we assessed the effect of this strain on the clinical symptoms, QoL, and changes in the faecal microbiota composition in patients with IBS.…”

Section: Introductionmentioning

confidence: 97%

“…We previously isolated a unique strain of Lactobacillus gasseri (registered as CP2305) from the stool samples of a healthy volunteer. CP2305 showed a 40% chance of colonizing the digestive tracts of volunteers (Sawada et al 2016). In the present study, we assessed the effect of this strain on the clinical symptoms, QoL, and changes in the faecal microbiota composition in patients with IBS.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effects of administration of theLactobacillus gasseristrain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome

et al. 2016

View full text Add to dashboard Cite

show abstract

“…1998 R&D report of the Calpis Co., Ltd.; Sawada et al . ). The European Food Safety Authority includes L. gasseri in the list of species with a Qualified Presumption of Safety.…”

Section: Methodsmentioning

confidence: 97%

Section: Probioticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of administration of theLactobacillus gasseristrain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome

et al. 2016

View full text Add to dashboard Cite

show abstract

“…from Clostridium cluster IV, known for producing higher amounts of SCFA (Sawada et al, 2016). The 537…”

mentioning

confidence: 99%

Production of multiple bacteriocins, including the novel bacteriocin gassericin M, byLactobacillus gasseriLM19, a strain isolated from human milk

García-Gutiérrez

O’Connor

Colquhoun

et al. 2019

Preprint

View full text Add to dashboard Cite

Bacteriocins are antimicrobial peptides produced by bacteria and their production by health-promoting microbes is regarded as a desirable probiotic trait. We found that Lactobacillus gasseri LM19, a strain isolated from human milk, exhibits antagonistic activity against different enteropathogens and produces several bacteriocins, including a novel bacteriocin, gassericin M. These bacteriocins were purified from culture and synthesised to investigate their activity and potential synergy. L. gasseri LM19 was tested in a complex environment mimicking human colon conditions where it not only survived but expressed the seven bacteriocin genes and produced short chain fatty acids. Metagenomic analysis of these in vitro colon cultures showed that co-inoculation of L. gasseri LM19 with Clostridium perfringens gave profiles with more similarity to controls than to vessels inoculated with C. perfringens alone. This makes L. gasseri LM19 an interesting candidate for further study for maintaining homeostasis in the gut environment.

show abstract

A multifaceted approach to harness probiotics as antagonists on plant based foods, for enhanced benefits to be reaped at a global level

Karunaratne

2018

J Sci Food Agric

View full text Add to dashboard Cite

Investigations into probiotics have focused on their health benefits thus far, with some of the findings finally reaching the food and pharmaceutical industries, which have used them for commercial purposes. In biocontrol research some microbes, mainly isolated from plants, have shown antagonism towards both enteric and plant pathogens, and some of them represent probiotic species. Fresh fruits and vegetables are regarded as health-promoting dietary constituents, and if probiotics could be used to control the pathogens on them then they could turn out to be even healthier. The fresh produce industry still depends on agrochemicals and the increase in the demand for high-priced organically grown produce indicates consumer concerns regarding the use of agrochemicals. If the potential of probiotic organisms to serve as biocontrol agents for fresh produce is exploited, all fresh produce can be made as safe as organically grown produce, and much more wholesome. This review appraises the feasibility of such a move by evaluating how research has progressed in both disciplines (probiotic and biocontrol) and suggests sharing results from research via information technology, efficient collaboration, and the use of novel molecular biological tools to achieve the objective of probiotic antagonists. © 2018 Society of Chemical Industry.

show abstract

Effect of continuous ingestion of a beverage prepared with Lactobacillus gasseri CP2305 inactivated by heat treatment on the regulation of intestinal function

Cited by 75 publications

References 26 publications

The effects of administration of theLactobacillus gasseristrain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome

The effects of administration of theLactobacillus gasseristrain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome

Production of multiple bacteriocins, including the novel bacteriocin gassericin M, byLactobacillus gasseriLM19, a strain isolated from human milk

A multifaceted approach to harness probiotics as antagonists on plant based foods, for enhanced benefits to be reaped at a global level

Contact Info

Product

Resources

About