Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

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PURPOSE:To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS:A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects. RESULTS:The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52).Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60). CONCLUSIONS:The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated whit meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model.

Section: Discussionmentioning

confidence: 99%

Copaiba oil effect on experimental jaw defect in Wistar rats

Silva

Brito

Pontes³

et al. 2015

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“…Copaiba oil has been used by several authors to test its anti-inflammatory and antimicrobial effects [17][18][19] , and the results have shown that the main active components responsible for these properties are the diterpenes and sesquiterpenes, as bisabolol and beta betacariofileno 9 . Knowing that the copaiba used in this study does not show effects against gram-negative bacteria 13 and that the model of CLP primarily deflagrates gramnegative septicemia, it is believed that the determining factor for increasing animal survival was the anti-inflammatory action of this plant, by modulating the inflammatory response and subsequent issue damage mediated by free radicals and proinflammatory citocinais against sepsis.…”

Section: Discussionmentioning

confidence: 99%

Copaiba oil effect under different pathways in mice subjected to sepsis

Botelho

Silveira²,

Lopes

et al. 2014

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PURPOSE:To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed.The Kaplan-Meier curves of surviving time were realized. RESULTS:All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05) CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.

“…Copaiba oil administered seven days before and therapeutically liver damage from paracetamol showed hepatoprotective effects, however, was only analyzed the effects within 24 hours after injury, thus, further studies should be conducted to understand whether longer periods in the oil copaiba can cause harm liver, as well as studies to identify the active principle and / or how this oil works to reduce liver damage 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Copaiba oil stands out among the Amazonia`s medicinal plants due to be attributed to this an important anti-inflamatory effect 17,18 and a function that promotes protection in the liver tissue 19 .…”

Section: Introductionmentioning

confidence: 99%

Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

Teixeira

Yamaki²,

Yasojima

et al. 2013

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PURPOSE:To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol.METHODS Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS:The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION:Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.