Effect of copper oxide nanoparticles on electrical conductivity and cell viability of calcium phosphate scaffolds with improved mechanical strength for bone tissue engineering

Sahmani, S.; Shahali, Maryam; Nejad, Mazyar Ghadiri; Khandan, Amirsalar; Aghdam, M.M.; Saber‐Samandari, Saeed

doi:10.1140/epjp/i2019-12375-x

Cited by 65 publications

(15 citation statements)

References 54 publications

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“…Partikel nano CuO dapat digunakan sebagai komponen utama dalam tulang manusia dengan memberi hasil kesehatan yang tepat. Selain itu, keunggulan CuO ini dapat berhubungan dengan penyakit seperti anemia, neutropenia dan kelainan bentuk tulang, yang biasa terjadi pada tulang manusia (Sahmani et al, 2019). Lebih lanjut, CuO dapat meningkatkan kinerja kimia dan mekanik tulang, sehingga dapat meningkatkan osteogenesis dalam perancah tulang (Sahmani et al, 2018;Ye et al, 2018).…”

Section: Pendahuluanunclassified

Sintesis dan Karakterisasi Nanokomposit Hidroksiapatit/Tembaga Oksida Sebagai Antibakteri Escherchia coli

Hariyanto¹,

Hakim²,

Ananingtyas³

et al. 2022

Bri

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Pengolahan limbah cangkang Achatina Fulica yang dimanfaatkan sebagai bahan dasar utama pembuatan hydroxyapatite (HAp). Dalam upaya menjaga perfomanya, HAp dikompositkan dengan material yang memiliki kemampuan khusus yang sama dan biokompatibilitasnya sangat baik yaitu CuO. Setelah dilakukan komposit material, hasil dari sintesis tersebut dimasukkan ke tahap karakterisasi menggunakan XRD menunjukkan HAp muncul pada = 25,9 o ; 31,9 o ; 39,57 o ; 46,62 o , 49,47 o . Untuk puncak CuO terdeteksi pada 2-teta = 35,544 o , 38,709 o , 48,717 o , 58,265, dan 61,526 o . Selanjutnya, untuk data hasil FTIR menunjukkan terdeteksinya puncak Cu-O berada dalam kisaran 400 hingga 600 cm -1 . Untuk puncak Hap terdeteksi gugus fungsi fosfat (PO 4 3 ) pada kisaran 560, 618, 987, dan 1060 cm -1 . Sedangkan fungsi karbonat (CO3 2-) pada kisaran 910 cm -1 dan 1630-1670 cm -1 . Berdasarkan aktivitas antimikroba, pada nanokomposit Hap/CuO menunjukkan kemampuan yang baik dalam membunuh koloni bakteri yang sangat baik.

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Section: Pendahuluanunclassified

Sintesis dan Karakterisasi Nanokomposit Hidroksiapatit/Tembaga Oksida Sebagai Antibakteri Escherchia coli

Hariyanto¹,

Hakim²,

Ananingtyas³

et al. 2022

Bri

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show abstract

“…Apart from Cu nanoparticles, their oxidized form, copper oxide nanoparticles have been considered as new additives for particular treatment in bone tissue engineering. Sahmani et al (2019) were synthesized a new bionanocomposite scaffold composed by natural hydroxyapatite and different weight fractions of copper oxide (CuO) nanoparticles and coating them with gelation polymer loaded with ibuprofen drug (gelatin‐IBO). The mechanical and biomedical properties of designed scaffold were evaluated for drug delivery and tissue engineering.…”

Section: Applications Of Metal Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Metal‐based nanoparticles for bone tissue engineering

Eivazzadeh‐Keihan

Noruzi

Chenab

et al. 2020

J Tissue Eng Regen Med

151

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Tissue is vital to the organization of multicellular organisms, because it creates the different organs and provides the main scaffold for body shape. The quest for effective methods to allow tissue regeneration and create scaffolds for new tissue growth has intensified in recent years. Tissue engineering has recently used some promising alternatives to existing conventional scaffold materials, many of which have been derived from nanotechnology. One important example of these is metal nanoparticles. The purpose of this review is to cover novel tissue engineering methods, paying special attention to those based on the use of metal‐based nanoparticles. The unique physiochemical properties of metal nanoparticles, such as antibacterial effects, shape memory phenomenon, low cytotoxicity, stimulation of the proliferation process, good mechanical and tensile strength, acceptable biocompatibility, significant osteogenic potential, and ability to regulate cell growth pathways, suggest that they can perform as novel types of scaffolds for bone tissue engineering. The basic principles of various nanoparticle‐based composites and scaffolds are discussed in this review. The merits and demerits of these particles are critically discussed, and their importance in bone tissue engineering is highlighted.

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“…68 Multiple reports have suggested that copper nanoparticles could be deployed to develop materials with excellent bioactivity and antimicrobial ability, thereby making a promising contribution to infection prevention and the treatment of bone defects. [69][70][71] Sahmani et al 70 When exposed to air, copper nanoparticles will rapidly form copper oxide nanoparticles, which are toxic to human cells and organs. 74,75 Wang et al 76 67 These data indicate that exposure to copper and copper oxide nanoparticles may carry particular risks, such as gene alteration, homeostasis disturbance, and so forth.…”

Section: Copper (Cu) and Copper Oxide (Cuo) Nanoparticlesmentioning

confidence: 99%

Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

2020

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Bone defects and diseases are devastating, and can lead to severe functional deficits or even permanent disability. Nevertheless, orthopedic implants and scaffolds can facilitate the growth of incipient bone and help us to treat bone defects and diseases. Currently, a wide range of biomaterials with distinct biocompatibility, biodegradability, porosity, and mechanical strength is used in bone-related research. However, most orthopedic implants and scaffolds have certain limitations and diverse complications, such as limited corrosion resistance, low cell proliferation, and bacterial adhesion. With recent advancements in materials science and nanotechnology, metallic and metallic oxide nanoparticles have become the subject of significant interest as they offer an ample variety of options to resolve the existing problems in the orthopedic industry. More importantly, these nanoparticles possess unique physicochemical and mechanical properties not found in conventional materials, and can be incorporated into orthopedic implants and scaffolds to enhance their antimicrobial ability, bioactive molecular delivery, mechanical strength, osteointegration, and cell labeling and imaging. However, many metallic and metallic oxide nanoparticles can also be toxic to nearby cells and tissues. This review article will discuss the applications and functions of metallic and metallic oxide nanoparticles in orthopedic implants and bone tissue engineering.

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Effect of copper oxide nanoparticles on electrical conductivity and cell viability of calcium phosphate scaffolds with improved mechanical strength for bone tissue engineering

Cited by 65 publications

References 54 publications

Sintesis dan Karakterisasi Nanokomposit Hidroksiapatit/Tembaga Oksida Sebagai Antibakteri Escherchia coli

Sintesis dan Karakterisasi Nanokomposit Hidroksiapatit/Tembaga Oksida Sebagai Antibakteri Escherchia coli

Metal‐based nanoparticles for bone tissue engineering

Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

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