Effect of Cornus mas fruit flavonoids on memory retention, level of plasma glucose and lipids in an intracerebroventricular streptozotocin-induced experimental Alzheimer’s disease model in Wistar rats

Abstract

Poor nutrition, poor mobility, obesity and ageing increase the possibility of neuronal disorder and Alzheimer's disease. This study examined effect of Cornus mas flavonoids on memory retention and the level of plasma glucose and lipids in an intra-cerebroventricular streptozotocin-induced experimental Alzheimer's disease model in Wistar rats. Intracerebroventricular administration of streptozotocine (3 mg kg-1) was performed and the animals memory were evaluated through passive avoidance tasks. Five groups (saline-saline control, streptozotocine-saline, and streptozotocine with different flavonoid doses [5, 10, 20 mg kg -1 ]) were examined. Animals received different doses of C. mas flavonoids or saline for three weeks starting one day before surgery. Rat weight was measured at the beginning of each week. Injection of streptozotocine significantly reduced memory retention, compared to the control group. Flavonoid treatment increased memory retention in a dose-dependent manner, and triglyceride and glucose concentration decreased memory retention. At the same time, high-density lipoprotein concentration increased without any effect on low-density lipoprotein concentration. The dose of 10 mg kg -1 decreased rat weight significantly. Our findings show that C. mas flavonoids can optimize cognitive deficits caused by injections of streptozotocine and also have a few positive effects on reducing the risk factors in the serum.

Iridoids, Flavonoids, and Antioxidant Capacity of Cornus mas, C. officinalis, and C. mas × C. officinalis Fruits

“…This species originates from the Caucasus and from there it spread through Turkey, Romania, Bulgaria, and further on European continent [ 1 , 2 ]. A very rich composition of biologically active compounds found in the fruits of Cornus mas [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ], which have a wide range of pharmacological action, such as antibacterial [ 7 , 11 , 12 ], hypolipidemic [ 7 ], antioxidant [ 6 , 13 ], anticoagulant [ 14 ], antiparasitic [ 15 ], cardioprotective [ 16 ], anticancer [ 17 ], hepatoprotective [ 18 ], and anti-inflammatory [ 19 ], and according to [ 20 ], could constrain the incidence of long-term complications of diabetes mellitus. Biologically active compounds are not only in fruits, but also in flowers, leaves, bones, and bark.…”

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

“…Anthocyanins derived from cornelian cherry improve cerebral circulation (nutrient and oxygen supply to the brain), which stops or reduces the rate of brain degeneration processes. Darbandi et al [ 55 ] examined the effect of anthocyanins derived from C. mas on memory in an experimental model of Alzheimer’s Disease induced by streptozotocin injected into the cerebral ventricles of rats ( Table 2 ). Anthocyanin treatment improves memory, depending on dosage.…”

Cornus Mas L. and its Importance in Phytotherapy

“…32 Cornus mas flavonoidlerinin, intraserebroventriküler streptozotosin ile indüklenen deneysel Alzheimer hastalığı modeli sıçanlarda hafıza bozukluğunu önemli ölçüde önlediği bildirilmiştir. 34 Sıçanlarda penisilinle epileptiform oluşturulmuş ve intraperitonel olarak kızılcık meyvesi ekstresi verilmiştir. Düşük (2,5-5 mg/kg) ve orta (10 mg/kg) dozlarda kızılcığın epileptiform aktivitenin amplitüdünü değiştirmediği, ancak ortalama frekansı önemli ölçüde düşürdüğü bildirilmiştir.…”