There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline. Behavioral test (the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease.

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Male infertility comprises half of the infertility cases (Miamoto, Minase, Okabe, Ueda & Sengoku, 2015). Various factors including problems in sperm production, maturation and fertilisation ability can affect male reproductive health, leading to male infertility. According to the WHO guidelines (World Health Organization, 2010), semen parameters such as the number, motility and morphology are regarded as reliable predictors of fertility. However, the assessment of these factors may be not sufficient for the diagnosis of infertility, as there are infertile men with a normal spermiogram (Brito, Barth, Bilodeau-Goeseels, Panich, & Kastelic, 2003). Therefore, it seems important to consider other sperm parameters for a clinical diagnosis of infertility. Acrosome reaction plays a critical role in sperm penetration into the oocyte and its fertilisation ability (Jin & Yang, 2017). Since this process