Impact of aluminium toxicity on vital human sperm parameters—Protective effects of silymarin

Aghashahi, Masoumeh; Momeni, Hamid Reza; Darbandi, Niloufar

doi:10.1111/and.13742

Cited by 15 publications

(9 citation statements)

References 49 publications

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“…However, the results obtained show that a greater presence of Al in semen exerts a detrimental effect on the fertilization process, although it does not appear to impair seminal parameters. An underlying cause for the toxic effects of aluminium chloride was found to be the oxidative stress that affects the vital sperm parameters, lipid peroxidation, and the total antioxidant capacity of spermatozoa, but this effect can be reversed by antioxidant use [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Seminal Metals on Assisted Reproduction Outcome

Rodríguez-Díaz

Blanes-Zamora

Vaca-Sánchez

et al. 2022

Biol Trace Elem Res

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Increased levels of metal ions in human seminal fluid have a significant correlation with male fertility. Few publications explain the effect of metals in semen and their influence on assisted reproductive treatments. Semen parameters and the levels of twenty-two metals were measured in the seminal fluid of 102 men attended in a Reproductive Unit. Metals were determined by optical emission spectrophotometry. A statistical relationship was found between spermiogram and iron, which was lower than expected in pathological spermiograms (p = 0.032); zinc (p = 0.066), calcium (p = 0.047), and magnesium (p = 0.048) mean levels were higher in normozoospermics. More days of sexual abstinence correlates with higher seminal zinc (p = 0.001) and magnesium levels (p = 0.002). Lower vanadium values were found to be associated with higher fertilization rates (p = 0.039). Higher values of lead (p = 0.052) and vanadium (p = 0.032) were obtained in patients who did not reach 100% embryo cleavage rate. Aluminium (p = 0.042) and sodium (p = 0.002) were found in lower amounts associated with better blastocyst rates. The implantation rate shows an inverse association with women’s age and iron and calcium content, compared to magnesium and sodium which presented a significant direct association with this percentage. A significant direct relationship was found between the positive evolution of pregnancy and the values of zinc (p = 0.004), calcium (p = 0.013), potassium (p = 0.002), and magnesium (p = 0.009). The study confirms that zinc, iron, calcium, sodium, aluminium, magnesium, vanadium, and lead have positive–negative effects on reproduction and support the analysis of metals in semen as a new line of study on male fertility with implications for reproductive outcomes.

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Section: Discussionmentioning

confidence: 99%

Influence of Seminal Metals on Assisted Reproduction Outcome

Rodríguez-Díaz

Blanes-Zamora

Vaca-Sánchez

et al. 2022

Biol Trace Elem Res

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“…In the reproductive system, the natural active product found in crucifers, such as broccoli sprouts and sulforaphane, showed the potential to lower AlCl 3 -induced testicular toxicity in rats [71]. Furthermore, several different sources of antioxidant substances such as vitamin C [72], selenium-rich yeast [73], Citrullus lanatus seed ethanol extract [74], tyrosyl (an antioxidant present in olive oil) [75], and curcumin [76] show protective effects against reproductive Al toxicity probably due to their antioxidant and antiapoptotic properties. Therefore, our results suggest that oral supplementation with pepsin-EWH at 1 g/kg b.w./day could prevent the harmful effects of Al s increased human body burden.…”

Section: Discussionmentioning

confidence: 99%

Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats

et al. 2022

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Aluminum (Al) is a non-essential metal omnipresent in human life and is considered an environmental toxicant. Al increases reactive oxygen production and triggers immune responses, contributing to chronic systemic inflammation development. Here, we have tested whether an egg white hydrolysate (EWH) with potential bioactive properties can protect against changes in reproductive function in rats exposed to long-term Al dietary levels at high and low doses. Male Wistar rats received orally: low aluminum level group—AlCl3 at 8.3 mg/kg b.w. for 60 days with or without EWH (1 g/kg/day); high aluminum level group—AlCl3 at 100 mg/kg b.w. for 42 days with or without EWH (1 g/kg/day). The co-administration of EWH prevented the increased Al deposition surrounding the germinative cells, reducing inflammation and oxidative stress in the reproductive organs. Furthermore, the daily supplementation with EWH maintained sperm production and sperm quality similar to those found in control animals, even after Al exposure at a high dietary contamination level. Altogether, our results suggest that EWH could be used as a protective agent against impairment in the reproductive system produced after long-term exposure to Al at low or high human dietary levels.

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“…The normal histological structure of the seminiferous tubule, vas deferens, epididymis and prostate were shown to be destroyed in the presence of Al (Al‐murshidi et al, 2021). Other studies have shown that high Al levels in seminal plasma can reduce sperm viability and motility (Aghashahi et al, 2020). Al was shown to reduce testosterone levels not only at high doses but also at low doses and can negatively affects sperm parameters (Mouro et al, 2018).…”

Section: Introductionmentioning

confidence: 96%

Protective effects of L ‐arginine against aluminium chloride‐induced testicular damage in rats

Yildirim¹,

Çolakoğlu

Kaya

2022

Andrologia

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Aluminium (Al) is a toxic metal with frequent exposure because it is a common element in nature and is found in many products used in daily life. L-arginine is a semi-essential amino acid that is involved in many biochemical pathways in the body and has antioxidant effects. The current research evaluated the possible protective effects of L-arginine against aluminium chloride (AlCl 3 ) induced testicular damage. In this animal-based experimental study, 28 male Wistar Albino rats were separated into four groups: control, Al (20 mg/kg/day Al), Al + L-arginine (20 mg/ kg/day Al + 50 mg/kg/day L-arginine), and L-arginine (50 mg/kg/day L-arginine). All applications were carried out intraperitoneally (i.p.) for 4 weeks. The histopathological changes caused by exposure to Al in the testicular tissue and the protective effects of L-arginine were investigated by using biochemical, histochemical, immunohistochemical [4-hydroxynonenal (4-HNE) and 8-hydroxy-2 0 -deoxyguanosine (8-OHdG)] and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay techniques. The testicles in the AlCl 3 group showed increased 4-HNE, 8-OHdG expressions, apoptotic index, and abnormal sperm content, while serum testosterone levels, sperm motility, and sperm number were decreased (p < 0.05). Furthermore, histomorphometric examinations of testicular tissue indicated significant structural impairments such as vacuolization in the seminiferous tubule epithelium, edema, and vascular congestion in the interstitial area (p < 0.05).

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Impact of aluminium toxicity on vital human sperm parameters—Protective effects of silymarin

Cited by 15 publications

References 49 publications

Influence of Seminal Metals on Assisted Reproduction Outcome

Influence of Seminal Metals on Assisted Reproduction Outcome

Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats

Protective effects of L ‐arginine against aluminium chloride‐induced testicular damage in rats

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