Effect of corticosteroid therapy on bromsulphthalein excretion in active chronic hepatitis.

Cook, G.C.; Velasco, Marta; Sherlock, Sheila

doi:10.1136/gut.9.3.270

Cited by 21 publications

(4 citation statements)

References 53 publications

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“…These drugs also have a beneficial influence on hepatic organic anion uptake as evidenced by significantly decreased BSP retention, relative hepatic storage (S) for BSP (Cook, Velasco, and Sherlock, 1968), and, in the present study, an impressive increase in ICG Rmax in the only patient (MM) studied before and after treatment with prednisolone.…”

Section: Discussionsupporting

confidence: 62%

Influence of azathioprine on hepatic reserve in chronic active liver disease.

Rikkers¹,

Sherlock²

1975

Gut

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Howard, 1967).Following the demonstration that hepatic uptake of ICG is a saturable process (Hunton, Bollman, and Hoffman, 1961), Paumgartner, Probst, Kraines, and Leevy (1970) utilized classical MichaelisMenten enzyme kinetics to determine the maximal rate of ICG removal (Rmax) from disappearance rates of multiple, submaximal doses. The discovery of a close correlation between regenerating liver mass in the rat and Rmax by Rikkers and Moody (1974a) encouraged the application of this technique to the clinical estimation of hepatic reserve.The purposes of the present investigation are twofold: (1) to determine if hepatic removal of ICG in patients with chronic active liver disease follows saturation kinetics, allowing calculation of Rmax, and (2) to assess the role of azathioprine in the management of these patients by evaluating the influence of this drug on Rmax.

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Section: Discussionsupporting

confidence: 62%

Influence of azathioprine on hepatic reserve in chronic active liver disease.

Rikkers¹,

Sherlock²

1975

Gut

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“…An increase in Tm has not been described in any disease state. S is usually decreased in patients with hepatocellular disease [11] and is known to increase in the presence of steroids [4], The significance of the changes in Tm and S in our cases is not known.…”

Section: Discussionmentioning

confidence: 82%

Hepatotoxicity Due to Pemoline

Tolman¹,

Freston²,

Berenson³

et al. 1973

Digestion

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Pemoline, a central nervous system stimulant, has been used extensively in Great Britain and Europe for a variety of conditions including memory failure and depression. In the 10 years that the drug has been used no report of hepatotoxicity has appeared. A prospective study of efficacy and safety of pemoline was started in the United States approximately 3 years ago. This report describes two patients who developed reversible liver abnormalities while receiving pemoline during the study and following rechallenge with the drug.

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“…-Corticoides. Su empleo en las hepatitis crónicas suele producir una rápida mejoría clínica y biológica, disminuyendo la bilirrubina, transaminasas y gammaglobulinas (IgG sobre todo) 20 • 23 • 28 • 34 • 43 • 44 y observándose además un aumento de la albúmina y de la excreción de bromosulftaleina 7 • Reducen la morbilidad y por lo tanto el periodo de hospitalización, así como la mortalidad en los enfermos con HCA, al menos en las series referidas por diversos autores 6 , e, 3o, 36 .…”

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2016

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Effect of corticosteroid therapy on bromsulphthalein excretion in active chronic hepatitis.

Cited by 21 publications

References 53 publications

Influence of azathioprine on hepatic reserve in chronic active liver disease.

Influence of azathioprine on hepatic reserve in chronic active liver disease.

Hepatotoxicity Due to Pemoline

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