Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders

Das, Undurti N.; Mohan, Iyyapu Krishna; Raju, T. Ravi

doi:10.1054/plef.2001.0311

Cited by 36 publications

(19 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the patients with Graves' ophthalmopathy, peripheral ROS metabolism has not been studied yet. However, oxidative stress peripheral markers (ROOH, malonyldialdehyde, chemiluminescence) reported to be on the increase in papers concerning various types of local inflammation can be found [31,33,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Peripheral parameters of oxidative stress in patients with infiltrative Graves’ ophthalmopathy treated with corticosteroids

2004

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Peripheral parameters of oxidative stress in patients with infiltrative Graves’ ophthalmopathy treated with corticosteroids

2004

View full text Add to dashboard Cite

“…In vitro studies Protective effects of n-3 fatty acids in diabetes have been also tested in vitro in a model of chemically induced cytotoxic damage to insulin-producing cells (RIN cells) (58). Here pretreatment of an insulin-secreting rat insulinoma cell line with ␣-LNA, EPA, and DHA prevented alloxan-induced cytotoxicity, although these fatty acids were less effective than LA (18:2 n-6) and ␥-LNA (18:3 n-6).…”

Section: Epidemiological Studiesmentioning

confidence: 99%

n-3 Fatty Acids in the Treatment of Diabetic Patients

et al. 2007

View full text Add to dashboard Cite

“…56 Besides, these fatty acids have been shown to modulate cell signaling mechanisms via their incorporation into the plasma membrane phospholipids. 57 Although the exact mechanism by which EPA/DHA exerted antioxidant action is not well understood, Das et al 58 have suggested in their study that EPA/DHA supplementation inhibited free radical generation and suppressed lipid peroxidation and NO synthesis in patients with nephritic syndrome. This finding suggests that EPA or DHA may be involved in scavenging of free radicals and NO.…”

Section: 2150-52mentioning

confidence: 99%

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

et al. 2006

View full text Add to dashboard Cite

Objective: We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring. Design: Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days. Measurements: Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitamin A, E and C concentrations, and (iii) antioxidant enzymes activities in erythrocytes. The plasma lipid concentrations and fatty acid composition were also determined. Results: Diabetes increased plasma triglyceride and cholesterol concentrations, whereas macrosomia was associated with enhanced plasma cholesterol and triglyceride levels, which diminished by feeding n-3 PUFA diet. N-3 PUFA diet also reduced increased plasma TBARS and corrected the decreased ORAC values in diabetic rats and their macrosomic offspring. EPAX diet increased the diminished vitamin A levels in diabetic mothers and vitamin C concentrations in macrosomic pups. Also, this diet improved the decreased erythrocyte superoxide dismutase and glutathione peroxidase activities in diabetic and macrosomic animals. Conclusion: Diabetes and macrosomia were associated with altered lipid metabolism, antioxidant enzyme activities and vitamin concentrations. N-3 PUFA diet improved hyperlipidemia and restored antioxidant status in diabetic dams and MAC offspring.

show abstract

Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders

Cited by 36 publications

References 44 publications

Peripheral parameters of oxidative stress in patients with infiltrative Graves’ ophthalmopathy treated with corticosteroids

Peripheral parameters of oxidative stress in patients with infiltrative Graves’ ophthalmopathy treated with corticosteroids

n-3 Fatty Acids in the Treatment of Diabetic Patients

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

Contact Info

Product

Resources

About