Effect of Cortisone on Survival of Skin Homografts in Rabbits

A Further Investigation of the Rôle of Skin Components in Chemical Carcinogenesis

“…Several thin Thiersch grafts were then taken from both treated sites on each animal, removing all the obviously thickened epidermis, and the attached dermis was removed after incubation with trypsin solution (Billingham and Medawar, 1951). The pieces of pure epidermis obtained were planted back on to the site contralateral to that from which they were derived.…”

Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance

“…If rejection was an immunological response as Medawar declared 50 yr ago (95), a logical strategy to prevent it would be to treat the recipient with agents that were known from other evidence to reduce immune reactivity. By 1951 Medawar (with Billingham and Krohn) (96) and the American Morgan (97) had taken this crucial step by showing that skin graft survival was prolonged with cortisone acetate and corticotropin. The year before, Dempster of Hammersmith Hospital, London, had demonstrated mitigation of skin graft rejection with total body irradiation (98).…”

History of Liver and Multivisceral Transplantation

“…82 ,83 However, the era of drug immunosuppression usually is designated to begin on the arrival of the drug 6-mercaptopurine (6-MP). After establishing that 6-MP was immunosuppressive without a need for overt bone marrow depression, 84 92 The article included a description of a kidney allograft that was still functioning under azathioprine immunosuppression 120 days after its transplantation from an unrelated donor on April 6, 1962.…”