Effect of cow’s milk with different PUFA n-6: n-3 ratios on performance, serum lipid profile, and blood parameters of grower gilts

Reis, Leriana Garcia; Silva, Thiago Henrique da; Salles, Márcia Saladini Vieira; Andrade, André Furugen Cesar de; Martins, Simone Maria Massami Kitamura; Takeuchi, Paula Lumy; Vidal, Ana Maria Centola; Netto, Arlindo Saran

doi:10.1371/journal.pone.0258629

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…This result explains that PUFA in the TR diet is not available for milk fat synthesis, as well as the effects of PUFA uptake on the function of membranes and cell signaling, as well as the regulation of gene expression via various transcription factors. As a result, PUFA affects virtually every cell in the body [38]. Other studies reported that a higher ALA content in the milk of cows and sheep was due to a feed high in PUFA [12,36].…”

Section: Discussionmentioning

confidence: 99%

Identifying the Influence of the Dietary Polyunsaturated Fatty Acid Content on Milk Quality Traits in Najdi Sheep at Different Stages of Lactation

Matar,

Abdelrahman,

Ayadi

et al. 2023

Applied Sciences

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The quality of milk is fundamental to producing safe milk and dairy products that are suitable for consumption. The objective of this study was to determine the influence that the content of dietary polyunsaturated fatty acids (PUFA) has on the total mixed ration (TMR) and lactation stage of milk’s composition and the fatty acid profile (FA) of the dairy Najdi breed. During the lactation period, 48 Najdi ewes used the following four treatments: traditional feed (TR) and three total mixed rations (TMR1, TMR2, and TMR3) with different PUFA content. Milk samples were taken from whole milk in the morning. The chemical composition and FA profile were analyzed. The results show that the ewes fed TMR1 with a PUFA content (25.20%) produced high-quality milk as they contained high levels of polyunsaturated fatty acids (PUSF), linoleic acid (LA), α-linolenic acid (ALA) and omega-3 (n3). On the other hand, the milk of ewes fed TMR2 with PUFA (15.06%) contained high levels of unsaturated fatty acids (USF) and monounsaturated fatty acids (MUFA) and had significantly reduced hypercholesterolemia (HFA). It can be concluded that milk fat, protein, and total solids in the milk of Najdi sheep increased as lactation progressed, while lactose remained constant. Furthermore, as lactation progressed, saturated fatty acids (SFA), stearic acids, and oleic acids (OA) increased while USF and MUFA decreased. TMR diets can directly benefit the producer and livestock by producing high-quality milk while reducing its economic value.

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Section: Discussionmentioning

confidence: 99%

Identifying the Influence of the Dietary Polyunsaturated Fatty Acid Content on Milk Quality Traits in Najdi Sheep at Different Stages of Lactation

Matar,

Abdelrahman,

Ayadi

et al. 2023

Applied Sciences

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n-3 PUFAs Show Promise as Adjuvants in Chemotherapy, Enhancing their Efficacy while Safeguarding Hematopoiesis and Promoting Bone Generation

Gurav,

Garad,

Nirmala

2024

CTMC

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Cancer ranks as the second leading cause of mortality in high-income countries, underscoring the critical need for effective therapeutic strategies. One prominent approach, chemotherapy, is widely employed for treating solid tumors. However, the significant adverse effects associated with chemotherapy, notably myeloablation and osteonecrosis, impart considerable challenges by compromising immune function and diminishing patients' quality of life. Furthermore, the emergence of chemotherapy resistance poses a formidable hurdle in achieving successful cancer treatment outcomes. In this context, the focus is on exploring alternative approaches to enhance the efficacy of cancer treatment and mitigate its adverse consequences. Among these approaches, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), two n-3 polyunsaturated fatty acids (PUFAs), have garnered substantial interest. These PUFAs exhibit the potential to influence membrane lipid composition and modulate critical gene expressions associated with cancer, such as Bcl-2, PI3K, NF-κB, and phosphorylated Akt, thereby potentially reducing cancer risk. Moreover, emerging evidence highlights their ability to augment chemotherapy efficacy, particularly in drug-resistant cancer cells. Importantly, both preclinical and clinical investigations have provided compelling evidence supporting the protective effects of n-3 PUFAs on healthy cells. Leveraging these findings, there has been growing attention on the exploration of n-3 PUFAs as adjuvants to chemotherapy. This strategic approach holds promise in mitigating the adverse effects linked to chemotherapy, notably myeloablation and osteonecrosis, while simultaneously enhancing its effectiveness in combating cancer. This comprehensive review delves into the multifaceted attributes of n-3 PUFAs, encompassing their cytotoxic properties, potential as chemopreventive agents, and their prospective role in ameliorating the adverse effects commonly associated with chemotherapy, with a particular emphasis on myeloablation and osteonecrosis. By elucidating the intricate interplay between n-3 PUFAs and cancer treatment paradigms, this review contributes to the expanding body of knowledge aimed at refining cancer therapeutic strategies and enhancing patient outcomes

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Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer

Neagu,

Josan,

Jayaweera

et al. 2024

IJMS

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Environmental exposure to a mixture of chemical xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis and the development of breast cancer (BC). Before anything else, we are what we eat. In this review, we highlight both “the good” and “the bad” sides of the daily human diet and dietary patterns that could influence BC risk (BCR) and incidence. Thus, regularly eating new, diversified, colorful, clean, nutrient-rich, energy-boosting, and raw food, increases apoptosis and autophagy, antioxidation, cell cycle arrest, anti-inflammation, and the immune response against BC cells. Moreover, a healthy diet could lead to a reduction in or the inhibition of genomic instability, BC cell stemness, growth, proliferation, invasion, migration, and distant metastasis. We also emphasize that, in addition to beneficial compounds, our food is more and more contaminated by chemicals with harmful effects, which interact with each other and with endogenous proteins and lipids, resulting in synergistic or antagonistic effects. Thus, a healthy and diverse diet, combined with appropriate nutritional behaviors, can exert anti-carcinogenic effects and improve treatment efficacy, BC patient outcomes, and the overall quality of life of BC patients.

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Effect of cow’s milk with different PUFA n-6: n-3 ratios on performance, serum lipid profile, and blood parameters of grower gilts

Cited by 4 publications

References 47 publications

Identifying the Influence of the Dietary Polyunsaturated Fatty Acid Content on Milk Quality Traits in Najdi Sheep at Different Stages of Lactation

Identifying the Influence of the Dietary Polyunsaturated Fatty Acid Content on Milk Quality Traits in Najdi Sheep at Different Stages of Lactation

n-3 PUFAs Show Promise as Adjuvants in Chemotherapy, Enhancing their Efficacy while Safeguarding Hematopoiesis and Promoting Bone Generation

Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer

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