Effect of Curacron Toxicity on Aminotransferases (ALT and AST) in the Serum of the Fish Cyprinus Carpio

Joseph, Baby; Raj, S. Justin

doi:10.3923/ijbc.2011.207.211

Cited by 11 publications

(4 citation statements)

References 14 publications

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“…The ALT and AST levels in tambaqui plasma (Table 3) found in our study did not differ significantly ( p ≥ .05) among the treatments. The AST and ALT levels found in this study were lower than the ones reported by Joseph and Raj (2011) in Cyprinus carpio after exposure to pesticides. According to these authors, aminotransferases are the biomarkers for hepatotoxicity of liver cells.…”

Section: Discussioncontrasting

confidence: 88%

Effect of a food additive in the control of the acanthocephalanNeoechinorhynchus buttneraeinColossoma macropomum

et al. 2020

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Section: Discussioncontrasting

confidence: 88%

Effect of a food additive in the control of the acanthocephalanNeoechinorhynchus buttneraeinColossoma macropomum

et al. 2020

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“…Alterations in the activities of the transaminases (AST and ALT) and ALP act as markers to illustrate compromised tissue integrity of the liver (Huculeci et al, 2008;Fıratet al, 2011;Banaee, 2013). Such increases could be proportional to compromised cellular integrity resulting from potential increase of cell membrane permeability (Granner and Rodwell, 2006), hepatocellular damage (Bhattacharya and Lun, 2005;Joseph and Raj, 2011), cholestasis and liver damage (Della Torre et al, 2000). ALP adopts different mode of action, preferentially influenced by exposure dose and duration, to elicit responses to contaminants (Brander et al, 2012;Sun et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Effects of acute exposure to chlorfenapyr on hepatic enzyme activities and serum lipid profile of African catfish, Clarias gariepinus (Burchell 1822)

Esenowo,

Nelson,

Ekpo

et al. 2023

wojast

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The effects of acute exposure to chlorfenapyr on hepatic enzymes and lipid profile of Clarias gariepinus juveniles were investigated following standard protocols. Test organisms were exposed to chlorfenapyr concentrations of 5, 7, 9, 11 and 15 mgL-1 for 96 hr exposure period. After exposure, peripheral blood was collected through the caudal vein into plain sterilised tubes and allowed stand for 1 h for clot to form. The clotted blood was then centrifuged at 3000 rpm for 10 min and the serum obtained was used for all the biochemical assay. Cross-sections of the gills were examined for histological aberrations. Results showed significant increase in enzymatic activities of Aspartate amino transferases (AST), Alanine amino transferases (ALT) and Alkaline phosphatase (ALP) (p< 0.05) when compared with control. Lipid profile results showed significant (p<0.05) increase in Total cholesterol (TC) and Low- density lipoprotein-cholesterol (LDL-cholesterol) in all treated groups when compared with the control. Significant (p<0.05) reduction in high density lipoprotein- cholesterol (HDL-cholesterol) and triacylglycerides in all treated groups compared to the control was also recorded. Such alterations in biochemical parameters did not show any relationship with gills histology as the cross-section of the gills provided no evidence of aberrations. The results suggest that exposure to acute concentrations of chlorfenapyr can alter liver enzyme activities and serum lipid profile initiating a jump in the energy requirement of the exposed organism.

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“…Two biochemical endpoints to assess liver damage and energetics were conducted in treated fish, aspartate aminotransferase (AST) activity, and glucose levels. AST was targeted because AST abundance is the most commonly used biomarker to determine liver damage. , Glucose levels were measured because glucose is a critical biomolecule for energetics and shown to be altered by pyrethroids in fish . AST activity was measured using the Aspartate Aminotransferase Colorimetric Activity Assay Kit (Cayman Chemical, Ann Arbor, MI) and glucose levels were determined using the Glucose Colorimetric Assay Kit (Cayman Chemical) according to the manufacturer’s instructions.…”

Section: Methodsmentioning

confidence: 99%

Dietary Exposure to Bifenthrin and Fipronil Impacts Swimming Performance in Juvenile Chinook Salmon (Oncorhynchus tshawytscha)

Magnuson

Fuller

Hartz

et al. 2022

Environ. Sci. Technol.

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Two commonly used insecticides, bifenthrin and fipronil, can accumulate in the prey of juvenile Chinook salmon, yet the effects of dietary exposure are not understood. Therefore, to better characterize the effect of a dietary exposure route, juvenile Chinook salmon were fed chironomids dosed with a concentration of 9 or 900 ng/g of bifenthrin, fipronil, or their mixture for 25 days at concentrations previously measured in field-collected samples. Chinook were assessed for maximum swimming performance (U max) using a short-duration constant acceleration test and biochemical responses related to energetic processes (glucose levels) and liver health (aspartate aminotransferase (AST) activity). Chinook exposed to bifenthrin and bifenthrin and fipronil mixtures had a significantly reduced swimming performance, although not when exposed to fipronil alone. The AST activity was significantly increased in bifenthrin and mixture treatments and glucose levels were increased in Chinook following a mixture treatment, although not when exposed to fipronil alone. These findings suggest that there are different metabolic processes between bifenthrin and fipronil following dietary uptake that may influence toxicity. The significant reductions in swimming performance and increased levels of biochemical processes involved in energetics and fish heath could have implications for foraging activity and predator avoidance in wild fish at sensitive life stages.

show abstract

Effect of Curacron Toxicity on Aminotransferases (ALT and AST) in the Serum of the Fish Cyprinus Carpio

Cited by 11 publications

References 14 publications

Effect of a food additive in the control of the acanthocephalanNeoechinorhynchus buttneraeinColossoma macropomum

Effect of a food additive in the control of the acanthocephalanNeoechinorhynchus buttneraeinColossoma macropomum

Effects of acute exposure to chlorfenapyr on hepatic enzyme activities and serum lipid profile of African catfish, Clarias gariepinus (Burchell 1822)

Dietary Exposure to Bifenthrin and Fipronil Impacts Swimming Performance in Juvenile Chinook Salmon (Oncorhynchus tshawytscha)

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