Effect of curcumin on cetrain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats

Nirmala, Chandrasekar; Puvanakrishnan, Rengarajulu

doi:10.1016/0006-2952(95)02118-3

Cited by 83 publications

(37 citation statements)

References 25 publications

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“…Increased heart weight and heart/body weight ratio indicates cardiac hypertrophy, which may be due to ventricular stiffness, increased water content and extensive necrosis of cardiac muscle followed by invasion of damaged tissue by inflammatory cells (17,18). In the present study, there was also a significant increase in heart weight and heart/body weight ratio in ISO-treated rats compared with control.…”

Section: Injected With Isoprenaline Subcutaneous [Sc]) C Pretreatedsupporting

confidence: 66%

Investigation of the cardioprotective effects of Crataegus oxycantha and its molecular mechanism

Parikh¹,

Tripathi²,

Shah³

et al. 2015

Curr Res Cardiol

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H Parikh, CB Tripathi, P Shah, V Ghori, RK Goyal. Investigation of the cardioprotective effects of Crataegus oxycantha and its molecular mechanism. Curr Res Cardiol 2015;2(4):161-167. BaCKGRound:Crataegus oxycantha has been used as a cardiotonic for the treatment of early stage congestive heart failure; however, there are few authentic investigational studies addressing its cardioprotective use. oBJECTIVE: To investigate the cardioprotective effect of C oxycantha and to elucidate its possible mechanism of action. METHodS:The effects of C oxycantha was studied using a rat model of isoproterenol (ISO) (100 mg/kg subcutaneous for two days) -induced myocardial necrosis. Cardiac damage was assessed using various biochemical enzymes and histological studies. Various oxidative parameters and Na + -K + ATPase activity were studied to elucidate the mechanism of action. RESulTS: Pretreatment with C oxycantha significantly prevented the increase in serum levels of cardiac troponin-I, creatine kinase-MB, lactate dehydrogenase, glutamate oxalotransaminase, glutamate pyruvate transaminase and uric acid in ISO-treated (100 mg/kg) rats. The increased serum levels of cholesterol, triglyceride, low-density lipoprotein cholesterol and atherogenic index after ISO administration were decreased to nearly normal levels by C oxycantha extract. Pretreatment with C oxycantha in ISOtreated animals produced significant decrease in lipid peroxidation and significant increase in endogenous antioxidant superoxide dismutase, catalase and reduced glutathione in myocardial tissue. C oxycantha extract significantly inhibited Na + -K + ATPase enzyme present in heart homogenate by virtue of presence of ursolic acid as evidenced by high-performance thin layer chromatography analysis of C oxycantha extract, which may be a possible mechanism of cardiotonic activity of C oxycantha. ConCluSIon: C oxycantha may be viewed as potentially cardiotonic, cardioprotective and antioxidant.

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Section: Injected With Isoprenaline Subcutaneous [Sc]) C Pretreatedsupporting

confidence: 66%

Investigation of the cardioprotective effects of Crataegus oxycantha and its molecular mechanism

Parikh¹,

Tripathi²,

Shah³

et al. 2015

Curr Res Cardiol

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“…In addition, pre-and co-treatment with curcumin could decrease the severity of pathological changes and have a protective effect against the damage caused by myocardial infarction in rats [30] . The infarcted rat heart also showed a decreased necrosis after curcumin treatment [31] . In another study, curcumin has also been demonstrated to inhibit platelet-activating-factor-and arachidonic-acid-induced platelet aggregation [32] .…”

Section: Discussionmentioning

confidence: 92%

Synergistic Inhibitory Effects of Curcumin and 5-Fluorouracil on the Growth of the Human Colon Cancer Cell Line HT-29

Jiang²,

Xia³

et al. 2005

Chemotherapy

127

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The synergistic effect of combination treatment with COX-2 inhibitors and chemotherapy may be another promising therapy regimen in the future treatment of colorectal cancer. Curcumin, a major yellow pigment in turmeric which is used widely allover the world, inhibits the growth of human colon cancer cell line HT-29 significantly and specifically inhibits the expression of COX-2 protein. However, the worldwide exposure of populations to curcumin raised the question of whether this agent would enhance or inhibit the effects of chemotherapy. In this report, we evaluated the growth-inhibitory effect of curcumin and a traditional chemotherapy agent, 5-FU, against the proliferation of a human colon cancer cell line (HT-29). The combination effect was quantitatively determined using the method of median-effect principle and the combination index. The inhibition of COX-2 expression after treatment with the curcumin-5-FU combination was also evaluated by Western blot analysis. The IC₅₀ value in the HT-29 cells for curcumin was 15.9 ± 1.96 µM and for 5-FU it was 17.3 ± 1.85 µM. When curcumin and 5-FU were used concurrently, synergistic inhibition of growth was quantitatively demonstrated. The level of COX-2 protein expression was reduced almost 6-fold after the combination treatment. Our results demonstrate synergism between curcumin and 5-FU at higher doses against the human colon cancer cell line HT-29. This synergism was associated with the decreased expression of COX-2 protein.

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“…Amongst the various mechanisms involved in free radical induced lipid peroxidation followed by myocardial ischaemia, a deterioration of antioxidant system in the myocardium is suggested [32]. In the present study, increased lipid peroxidation may be attributed to decreased catalase activity since the available literature described catalase as a significant enzyme in cardiac myocytes in terms of its low content but highest activity in scavenging hydrogen peroxides which otherwise generates lipid peroxides and lipid hydroperoxides.…”

Section: Discussionmentioning

confidence: 53%

“…Many plants are known to be a good source of carotenoids, triterpenes, flavonoids, and alkaloids that are potent to combat free radical mediated cardiac toxicity including myocardial infarction and ischemic heart diseases [33]. [32]. Coriandrum sativum, however, is not enlisted.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Ethanolic Leaf Extract of Coriandrum Sativum on Metanil Yellow Induced Alteration Inactivity of Catalase and Level of Lipid Peroxidation in Hercine Cardiac Tissue in Vitro

Dome¹,

Hazra²,

Ghosh³

et al. 2017

Int J Pharm Pharm Sci

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Objective: The primary aim of the study was to find out a suitable effective dose of metanil yellow that can cause alterations of lipid peroxidation and catalase activity in the heart in vitro and to determine the effectiveness of graded doses of Coriandrum sativum as an antioxidant in preventing lipid peroxidative damage to cardiac tissue and back up catalase activity. Methods:Metanil yellow at different doses (10, 25, 35, 50 µl in phosphate buffer) were applied on isolated hircine heart homogenate (10%) in in vitro followed by estimation of lipid peroxidation and catalase activity after completion of the incubation period. Another set of the experiment included incubation of the heart homogenates with graded dilutions of ethanolic leaf extracts of Coriandrum sativum (CsEth) at concentrations of 10, 20, 30, 40 µl in phosphate buffer medium followed by quantification of the same biochemical parameters as above. This was followed by coadministration of the selected effective dose of metanil yellow (35 µl) and ethanolic leaf extract of Coriandrum sativum (30 µl) on heart homogenate to track the variation in lipid peroxidation and catalase activity in heart homogenate in vitro.

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Effect of curcumin on cetrain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats

Cited by 83 publications

References 25 publications

Investigation of the cardioprotective effects of Crataegus oxycantha and its molecular mechanism

Investigation of the cardioprotective effects of Crataegus oxycantha and its molecular mechanism

Synergistic Inhibitory Effects of Curcumin and 5-Fluorouracil on the Growth of the Human Colon Cancer Cell Line HT-29

Beneficial Effects of Ethanolic Leaf Extract of Coriandrum Sativum on Metanil Yellow Induced Alteration Inactivity of Catalase and Level of Lipid Peroxidation in Hercine Cardiac Tissue in Vitro

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