Effect of Curcumin on Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress in Rats

Abstract

This study was designed to investigate the protective effects of curcumin against colchicine-induced cognitive impairment and oxidative stress in rats. Male Wistar rats (weighing 150-200 g) received colchicine intracerebroventricularly (15 microg per rat), and cognitive dysfunctions were evaluated by the Morris water maze and the plus maze performance task and supported by biochemical tests. Central administration of colchicine caused memory deficit in both the Morris water maze and the elevated plus maze task paradigm tasks. Chronic treatment with curcumin (5-50 mg/kg, p.o.) twice daily for a period of 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment. Biochemically, chronic administration of curcumin significantly reduced the elevated lipid peroxidation, restored the decreased reduced glutathione level and acetylcholinesterase activity, and attenuated the raised colchicine-induced elevated nitrite levels. The results of the present study indicate that curcumin has a protective role against colchicine-induced cognitive impairment and associated oxidative stress.

Neuronutrition and Alzheimer's Disease

“…Curcumin also protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine [189] and has also been reported to attenuate 3-nitropropionic acid-induced neurotoxicity [190]. In rat brain, curcumin protects against lead- and cadmium-induced lipid peroxidation as well as lead-induced tissue damage [191].…”

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

“…Epidemiologic data has shown that regular curcumin intake may be related to better cognitive function in healthy elderly [3], while in rat models curcumin appears to reverse various forms of cognitive impairment [4], [5], [6], [7], [8], [9]. For example, chronic administration of curcumin can ameliorate age-related spatial memory deficits [10].…”

“…For example, chronic administration of curcumin can ameliorate age-related spatial memory deficits [10]. These effects may be due to curcumin's activity on oxidative stress [4], [5], [7], BDNF and ERK/P38 kinase signalling pathways [6], degradation of PKCδ [10] or inhibition of histone acetyltransferase [11], as well as several other activities. Curcumin also may protect against Alzheimer's disease (AD) pathology.…”

Neuroprotective Effects ofCentella asiaticaagainst Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

“…Novel antioxidants may offer an effective and safe means of bolstering body's defense against free radicals [11] and thereby provide protection against AD like problems. Various natural antioxidants like curcumin, rosmarinic acid, huperzine A have been reported to have a neuroprotective effect against AD [12–14]. Centella asiatica (CA) L. Urban (syn.…”