Effect of Curing Agent on Sodium Alginate Blends Using Barium Chloride as Crosslinking Agent and Study of Swelling, Thermal, and Morphological Properties

Reddy, S. Giridhar; Pandit, Akanksha Saxena

doi:10.1080/00914037.2013.769236

Cited by 8 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Giridhar prepared biodegradable blends of sodium alginate (SA) with lignosulphonates (LS) [80]. The blends were cured by barium chloride as the crosslinker to achieve selective permeation and strong crosslinking.…”

Section: Blendsmentioning

confidence: 99%

Chemical Modifications of Alginate and Its Derivatives

Nataraj¹,

Reddy²

2020

Int J Chem Res

View full text Add to dashboard Cite

Alginate is a polysaccharide obtained from seaweeds that are abundantly available and have shown great potential for diverse industrial applications. However, alginate lacks properties such as stability under aqueous conditions and it is difficult to control the rate of degradation of alginate-based materials, crucial for various medical applications. Therefore, researchers have modified alginate using physical or chemical approaches to enhance physical properties, biocompatibility, solubility and also to control the biodegradability of alginate-based materials. Crosslinking using ionic, covalent, photo and enzymatic approaches are one of the preferred methods for modifying the properties of alginates and its derivatives. Crosslinking binds the individual polymer chains with one another to form a network that enhances mechanical properties and stability. Among the different crosslinking approaches, ionic crosslinking provides biomaterials with limited stability whereas biomaterials with high mechanical stability can be prepared by covalent crosslinking. Although a wide variety of crosslinking chemicals and approaches are available to make alginate suitable for various applications, the methods used, properties and applications of the cross-linked materials vary significantly between studies. There are very few reports that have compared and evaluated the benefits of using different crosslinking approaches and the properties and applications of cross-linked alginate. In this review, the various methods of crosslinking alginates, their advantages, and limitations have been reviewed with particular emphasis on medical applications of alginate. The data for writing the review was obtained using search engines like Google scholar, Sci-hub and Sci finder and the keywords used include alginate, crosslinking, ionic, covalent, photo, enzymatic, biomedical applications.

show abstract

Section: Blendsmentioning

confidence: 99%

Chemical Modifications of Alginate and Its Derivatives

Nataraj¹,

Reddy²

2020

Int J Chem Res

View full text Add to dashboard Cite

show abstract

“…This is likely due to an increased amount of crosslinking occurring as the alginate concentration is increased, therefore allowing for less expansion during water uptake. 32,33 The effect of zeolite content on swelling was assessed by comparing 4A0Z1C beads with 4A4Z1C and 4A8Z1C beads. The addition of the 1:1 ratio of zeolite was associated with the largest increase in swelling, likely due to zeolite's high water absorbance.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Zeolite‐loaded alginate‐chitosan hydrogel beads as a topical hemostat

et al. 2017

View full text Add to dashboard Cite

Hemorrhage is the leading cause of preventable death after a traumatic injury, and the largest contributor to loss of productive years of life. Hemostatic agents accelerate hemostasis and help control hemorrhage by concentrating coagulation factors, acting as procoagulants and/or interacting with erythrocytes and platelets. Hydrogel composites offer a platform for targeting both mechanical and biological hemostatic mechanisms. The goal of this work was to develop hydrogel particles composed of chitosan, alginate, and zeolite, and to assess their potential to promote blood coagulation via multiple mechanisms: erythrocyte adhesion, factor concentration, and the ability to serve as a mechanical barrier to blood loss. Several particle compositions were synthesized and characterized. Hydrogel bead composition was optimized to achieve the highest swelling capacity, greatest erythrocyte adhesion, and minimal in vitro cytotoxicity. These results suggest a polymer hydrogel-aluminosilicate composite material may serve as a platform for an effective hemostatic agent that incorporates multiple mechanisms of action. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1662-1671, 2018.

show abstract

Effect of the cross-linking agent on performances of NaCS-CS/WSC microcapsules

Wang

et al. 2016

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Effect of Curing Agent on Sodium Alginate Blends Using Barium Chloride as Crosslinking Agent and Study of Swelling, Thermal, and Morphological Properties

Cited by 8 publications

References 32 publications

Chemical Modifications of Alginate and Its Derivatives

Chemical Modifications of Alginate and Its Derivatives

Zeolite‐loaded alginate‐chitosan hydrogel beads as a topical hemostat

Effect of the cross-linking agent on performances of NaCS-CS/WSC microcapsules

Contact Info

Product

Resources

About