Effect of Cyclopentolate on In Vivo Schlemm Canal Microarchitecture in Healthy Subjects

Rosman, Mohamad; Skaat, Alon; Chien, Jason L; Ghassibi, Mark P.; Sarimiye, Tarela; Ritch, Robert; Liebmann, Jeffrey M.; Park, Sung Chul

doi:10.1097/ijg.0000000000000599

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…The resolution offered by today's OCT imaging devices has allowed clinicians to identify aqueous humour outflow structures, including the SC, as already described by many authors in healthy adults or those with glaucoma (Kagemann et al 2010; Usui et al 2011;Shi et al 2012;Chen et al 2013;Hong et al 2013Hong et al , 2014Skaat et al 2016Skaat et al , 2017Rosman et al 2017;Kuerten et al 2018).…”

Section: Discussionmentioning

confidence: 94%

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Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

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Purpose To measure the Schlemm's canal (SC) in vivo by Fourier‐domain optical coherence tomography (FD‐OCT) in a Caucasian paediatric population. Methods Participants of this cross‐sectional study were 290 healthy children. In the right eye of each child, SC cross‐sectional diameter and area measurements were made with the FD‐OCT instrument RTVue® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in 30 of the participants. Results Mean participant age was 10.7 ± 3.4 years (range 3–18). SC diameters could be measured in both quadrants in 70.6% and 70.4% of subjects, respectively. Mean SC diameters were similar (p = 0.125) for the temporal and nasal quadrants: 266.7 ± 84.1 μm (range 131–509) and 273.2 ± 77.3 μm (range 124–486), respectively. Mean SC areas were also similar (p = 0.167) for the two quadrants: 9975 ± 3514 μm2 (range 4000–23 000) versus 9688 ± 3297 μm2 (range 3000–24 000). No differences were detected in SC measurements according to gender, refractive error or angle and TM measurements (R ≤ 0.116; p ≥ 0.125). The exception was age which was directly correlated with SC size (p ≤ 0.041). The reproducibility of the SC measurements was excellent (intraclass correlation coefficients ≥0.936). Conclusion FD‐OCT allows the identification of the SC in children. Our data indicate an increase in SC size produced with age.

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Section: Discussionmentioning

confidence: 94%

“…), cyclopentolate (Rosman et al. ), trabeculoplasty (Skaat et al. ), canaloplasty (Grieshaber et al.…”

Section: Introductionmentioning

confidence: 99%

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

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“…Although cyclopentolate agents do not cause as much pupil dilation as other mydriatic agents do, several studies indicated that the use of 1% cyclopentolate agents might lead to little increase in the IOP. 17,18 However, the effect of 0.5% cyclopentolate has not been addressed. It is not clear whether or not there would be an increase in the IOP measurements when 0.5% cyclopentolate is administrated.…”

Section: Introductionmentioning

confidence: 99%

Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Alghamdi

Alrasheed

Nair

et al. 2021

OPTH

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“…The topically applied cycloplegic drops inducing both mydriasis and cycloplegia are widely used for detailed fundus examinations and cycloplegic refraction in outpatient clinic [1]. Cyclopentolate and tropicamide are the most commonly applied cycloplegic drops in clinics.…”

Section: Introductionmentioning

confidence: 99%

Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes

Sharif

Moghadam

Azizi

et al. 2020

Preprint

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Background: To compare the effect of cyclopentolate versus tropicamide eye drops on anterior surface corneal parameters using Keratograph 4 in myopic and emmetropic individuals.Methods: Fifty-eight participants included 29 emmetropic and 29 myopic individuals, were recruited, according to inclusion and exclusion criteria. At baseline visit, anterior surface corneal parameters were measured using Keratograph 4 Keratograph 4in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions.Results: Of 58 participants who completed the study, 29 (24 women, 5 men, age: 23.82± 2.78 years) were emmetropic and 29 (21women, 8 men, age: 23.66± 2.76 years) were myopic. Baseline mean spherical equivalents were -0.23±0.23 D and -2.45±1.03 D in emmetropic and myopic groups, respectively. The analysis of the data showed a significant hyperopic shift following instillation of both cycloplegic eye drops in both refractive groups. However, tropicamide results was statistically insignificant in comparison with cyclopentolate (p=0.49). The assessment of data revealed no statistically significant differences in anterior surface corneal parameters in baseline, tropicamide and cyclopentolate instillation in each refractive group, except IHD value with tropicamide in myopic group (p=0.02). The further analysis between refractive groups also showed no significant differences in anterior surface corneal parameters in each session.Conclusions: Present study indicates that cyclopentolate and tropicamide do not appear to affect corneal topographic parameters and hence can be trusted to capture topography data.

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Effect of Cyclopentolate on In Vivo Schlemm Canal Microarchitecture in Healthy Subjects

Abstract: Cyclopentolate causes a reduction in SC dimensions in healthy eyes. Future studies are warranted to determine the exact mechanism(s) of this change.

Cited by 8 publications

References 16 publications

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes

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