Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes

Stewart, Mary Ellen; Greenwood, Robert; Cunliffe, W. J.; Strauss, John S.; Downing, Donald T.

doi:10.1007/bf00455168

Cited by 49 publications

(20 citation statements)

References 21 publications

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“…Androgens in turn may infl uence follicular hyeprkeratinization [ 82 , 83 ]. This data is supported by the clinical observation that anti-androgen therapy with combined oral contraceptives reduces the number of comedones [ 84 ].…”

Section: Follicular Hyperkeratinizationsupporting

confidence: 66%

Acne Pathogenesis: What We Have Learned Over the Years

Dessinioti

2014

Pathogenesis and Treatment of Acne and Rosacea

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Section: Follicular Hyperkeratinizationsupporting

confidence: 66%

Acne Pathogenesis: What We Have Learned Over the Years

Dessinioti

2014

Pathogenesis and Treatment of Acne and Rosacea

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“…The decreased epidermal barrier function, because of reduced levels of linoleic acid in the sebum of acne patients [53], correlates with epidermal hyperplasia and follicular hyperkeratinization [54] and makes the wall permeable to inflammatory substances [55].…”

Section: Comedone Formationmentioning

confidence: 99%

Expert opinion and review article: The timing of comedone extraction in the treatment of premenstrual acne – a proposed therapeutic approach

Steventon¹

2010

Intern J of Cosmetic Sci

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Synopsis The face is the most exposed part of our body, and deterioration of facial appearance, through disease or ageing, causes psychological distress. Acne lesions and subsequent pigmentation changes contribute to the unevenness of skin colour that is detrimental to facial attractiveness and leads to rejection and stigmatization in our society. The purpose of this review is to look at the root causes of premenstrual acne and, for the first time ever, propose that the specific timing of treatment can, at least in part, resolve the acne lesions. We postulate that it is the timing of the manual extraction that matters in resolving premenstrual acne and that the effectiveness of this therapy could be improved. Based on the reviewed evidence, we propose that it is important to remove the comedones at the time of ovulation, prior to the reduction of the size of the sebaceous orifice and epidermal barrier function, to counteract the onset of increased sebum production, prevent blockage of the pores and subsequent bacterial colonization and inflammation. If performed successfully, the extraction may contribute to a reduction in inflamed acne lesions and thus benefit women by increasing their facial attractiveness, well‐being, social function and thereby decrease psychological stress.

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“…5α-Reductase (type 1) is present in the infrainfundibulum part of the duct as well as in the sebaceous gland [14]. The possible androgen-controlling effect is mirrored by a reduction in the number of comedones when a patient is prescribed anti-androgen therapy such as the oral contraceptive pill Dianette ® [15]. …”

Section: Aetiology Of Comedogenesismentioning

confidence: 99%

Comedogenesis: Some Aetiological, Clinical and Therapeutic Strategies

et al. 2003

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Hypercornification is an early feature of acne and usually precedes inflammation. It is associated with ductal hyperproliferation, and there are many controlling factors such as androgens, retinoids, sebum composition and cytokines. Cycling of normal follicles and of comedones may explain the natural resolution of comedones and, in the longer term, resolution of the disease itself. There is a need to tailor treatment according to comedonal type. Suboptimal therapy can often result from inappropriate assessments of comedones, especially microcomedones, sandpaper comedones, submarine comedones and macrocomedones. Macrocomedones can produce devastating acne flares, particularly if patients are inappropriately prescribed oral isotretinoin. Gentle cautery under topical local anaesthesia is a useful therapy in the treatment of such lesions. The newer retinoids and new formulations of all-trans-retinoic acid show a better benefit/risk ratio.

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Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes

Cited by 49 publications

References 21 publications

Acne Pathogenesis: What We Have Learned Over the Years

Acne Pathogenesis: What We Have Learned Over the Years

Expert opinion and review article: The timing of comedone extraction in the treatment of premenstrual acne – a proposed therapeutic approach

Comedogenesis: Some Aetiological, Clinical and Therapeutic Strategies

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