Effect of daidzein on Parkinson disease induced by reserpine in rats

Abstract

Parkinson disease is a neurodegenerative disorder characterised by the cardinal symptoms of stiffness, resting tremor, slowness (bradykinesia) and reduction of movement (hypokinesia). Involvement of oxidative damage has been reported in the pathophysiology of Parkinson disease and its related complications. The purpose of this study was to examine the effect of daidzein to quench the free radicals produced as a result of the increased oxidative stress in Parkinson disease.Parkinson disease is induced by administration of reserpine (5 mg/kg/day, i.p) for 5 consecutive days. The symptoms of PD such as tremors, akinesia and rigidity were evaluated. The effect was evaluated by assessing various behavioral parameters (grip strength and locomotor activity), biochemical parameters (lipid peroxidation, and reduced glutathione), as well as histopathological parameters in brain tissue. Daidzein (an antioxidant) was administered at the dose of 50 and 100 mg/kg, p.o. once daily for 5 days. Reserpine significantly causes tremor, rigidity, akinesia and oxidative damage which were reversed by daily administration of daidzein when compared toreserpine group. There was a significant histological improvement in the neuronal degeneration in brain tissue with daidzein. So, the results indicated the protective effect of daidzein against PD.

Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model

“…In this study, we employed a reserpine-induced animal model of PD that reflect aspects of PD neuropathology and mimics the human PD 23 , 37 . Reserpine, a potent VMAT2 inhibitor, induces muscular rigidity, tremors, and akinesia by depletion of central catecholamine storage 23 .…”

Pharmacokinetics, pharmacodynamics, toxicity, and formulations of daidzein: An important isoflavone

“…Daidzein treatment at a dose of 50 and 100 mg/kg significantly reduced reserpine‐induced tremor, rigidity, akinesia, and oxidative damage. Histopathological findings also confirmed that daidzein prevents neuronal degeneration in brain tissue (Goel & Chaudhary, 2020). The effect of daidzein on scopolamine‐induced cognitive impairment in male mice has also been studied, it was observed that daidzein treatment at dose 5 mg/kg significantly improved cognitive impairments via estrogen receptor which prevented neuron from oxidative damage (Kim et al, 2010).…”

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

“…It has been illustrated that daidzein (DZ) in combination with levodopa (L‐dopa) and carbidopa produced a significant reduction in the symptoms of reserpine‐induced PD that included muscular rigidity, tremors, and akinesia. Also, DZ significantly reduced the levels of lipid peroxidation and caused an increase in the GSH level suggesting that DZ can exert a neuroprotective efficacy in PD via restoring the level of DA and protection of dopaminergic neurons against apoptosis due to regulation of the antioxidant system (Goel & Chaudhary, 2020) (Figure 4).…”