Effect of Deep Anesthesia on Development of Post-Operative Cognitive Dysfunction

Voysekhovskiy, D. V.; Аveryanov, D. А.; Schegolev, Aleksey Valer'evich; Svistov, D. V.

doi:10.21292/2078-5658-2018-15-1-5-9

Cited by 4 publications

(9 citation statements)

References 14 publications

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“…The advantages of regional methods of anesthesia over general anesthesia are the ability to locally block nociceptive stimulation in the area of injury and surgery, no complications from the pulmonary system, improved microcirculation and hemostasis, control of pain sensitivity in the perioperative period which promote early activity of patients [18].…”

Section: Research Results and Discussionmentioning

confidence: 99%

The problem of choosing anesthesia method for surgical interventions on the lower limbs in young patients

Georgiyants

Popsuishapka

Ryndenko

et al. 2021

SR:MS

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The relevance of the topic is due to the prevalence of lower limbs injuries in people of working age, the complexity of the methods of their surgical treatment and the problem of finding the optimal method of anesthesia in terms of efficiency and safety. Objective of the study: to conduct a systematic analysis of modern scientific literature data on the possibility of using anesthesia methods during surgical interventions and in the case of anesthesia for injuries of the lower limbs in people of working age. Materials and methods. A search for scientific sources was carried out in the scientometric databases Scopus and Web of Science, Google Scholar, archives of journals using the keywords "general anesthesia", "regional anesthesia", "injuries of the lower limbs", "young people", "general anesthesia". The search depth was 8 years. Conclusions. The problem of choosing the method of anesthesia during traumatological surgeries in people of working age has no final solution. In general, both general and regional anesthesia can be used, despite their advantages and the possibility of complications in each case. However, in clinical practice over the past decade, general anesthesia is not always the best method of pain relief. But regional methods have less effect on the vital functions of the body, and the use of ultrasound navigation and modern local anesthetics in a minimum sufficient amount makes anesthesia conduction more effective and safe. The disadvantages of regional anesthesia can be avoided by combining it with general anesthesia. However, in the available literature, there are no recommendations on the differentiated choice of the method of anesthesia for surgical interventions on the lower limbs in people of working age and the factors that influence this

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Section: Research Results and Discussionmentioning

confidence: 99%

The problem of choosing anesthesia method for surgical interventions on the lower limbs in young patients

Georgiyants

Popsuishapka

Ryndenko

et al. 2021

SR:MS

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“…Загальна анестезія розглядається як фактор ризику виникнення або прискорення змін когнітивної функції. При цьому, структура та ступінь впливу препаратів для загальної анестезії на центральну нервову систему пов'язані з глибиною та тривалістю наркозу у кожному конкретному випадку [4,7,24,41,42,49,53,56]. Загальна анестезія може бути фактором виникнення різних уражень нервової системи у післяопераційному періоді [28,39,42,46,62].…”

Section: оригінальні дослідженняunclassified

“…На виникнення когнітивних порушень у даних пацієнтів впливає багато біохімічних та патофізіологічних механізмів: метаболічні, гемореологічні, гіпоксичні, токсичні, що призводять до пошкодження стінок церебральних судин на рівні мікроциркуляції [29,50,54,61]. Відомо, що препарати для загальної анестезії викликають зміни перфузії головного мозку, які в подальшому призводять до різноманітних порушень вищої нервової системи в післяопераційному періоді [4,5,18,26,52]. Післяопераційні зміни когнітивної функції деякі автори пояснюють наслідком апоптозу під впливом препаратів для загальної анестезії, особливо при великих дозах та тривалих операціях [42,22,31,38].…”

Section: оригінальні дослідженняunclassified

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Diagnosis of cognitive function changes in patients with abdominal neoplasms occurring in the early postsurgery period and management of those with neuroprotective drug

Дубівська

Григоров

2021

УРОЖ

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Background. The issue of analysis of diagnostic criteria and adequate neuroprotective management of postsurgery cognitive dysfunction in abdominal oncosurgery, depending on the degree and structure of disorders, remains unresolved, determining its relevance. Purpose – assessing the postsurgery cognitive dysfunction in patients with neoplasms of the abdominal cavity and management of possible disorders with citicoline depending on the level of general cognitive deficit. Materials and methods. TThe study was conducted at the premises of departments for patients of surgical profile of Municipal Institution “Kharkov City Clinical Hospital of Ambulance and Emergency Care named after Professor O.I. Meshchaninov”. To achieve the aim of the study, 80 patients with abdominal neoplasms who underwent surgery under general anesthesia using propofol and fentanyl were examined. Results and discussion. Based on the comprehensive clinical study and anal- ysis of the mechanisms of formation of postsurgery cognitive dysfunction in patients of oncosurgical profile after surgery under general anesthesia, we suggested directions and schemes for managing postsurgery cognitive dysfunction by means of the developed clinical diagnostic criterion, which is essential in forming individual scheme of treating patients in postsurgery period. Conclusions. Based on the analysis of data on the state of cognitive function changes, comparing the postsurgery period with the preoperative state, a differentiated approach to intensive neuroprotective therapy of postoperative cognitive dysfunction was developed. The technique of intensive neuroprotective therapy of postsurgery cognitive dysfunction in patients with abdominal neoplasms, undergoing surgery under general anesthesia, was suggested.

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“…From the perspective of practical anesthesiology, an important factor when selecting the anesthesia method is probability of complications developing both during, and after surgery [5,6]. Unfortunately, none of the anesthesia methods is deprived of adverse effects and events, however, most researchers indicate the relative safety of regional anesthesia while meeting the requirements of their implementation, adequate monitoring and consideration of counterindications [7,8].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Stress Laboratory Findings and Their Relation to Psychoemotional State During Regional Anesthesia in Patients With Lower Limbs Injuries

Korobko

2020

EUREKA: Health Sciences

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The choice of an adequate method of anesthesia for surgical treatment of lower limbs injuries remains a critical task today. Each method applied in this treatment has its advantages and disadvantages. In recent years, regional anesthesia has been the preferential method. The aim of the study. To study the stress laboratory findings and their relation to the patients’ psychoemotional state in perioperative period while performing regional and combined anesthesia. Material and methods. It was studied 60 patients aged 18-59 years, who underwent metal osteosynthesis operations due to lower limbs injuries. Surgical treatment was performed under regional anesthesia and regional anesthesia followed by sedation. The patients of both groups were conducted heamodynamics monitoring and determined the intensity of pain in accordance with visual analogue scale and stress indicators with a laboratory method. The psychoemotional state was assessed with the Spielberger-Hanin anxiety scale. Results. According to the study it was determined, that in patients, who were planned to have surgery, significant psychoemotional stress and stress concentration of hormones in the blood and their interrelation was discovered. Patients about before surgery had a relationship between situational anxiety and cortisol r=0.7; p=0.00006 in group I; r=0.6; p=0.002 in the second group. The relationship between VAS and cortisol r=0.5; p=0.04 in groups I and II. After surgery, the connection was in group I patients between situational anxiety and cortisol r=0.4; p=0.02; the relationship between insulin and the HOMA index r=0.5; p=0.01. Conclusions. Before the operation, all patients revealed significant psychoemotional stress and stressful changes in the concentration of hormones in the blood. Reliably pronounced dynamics of the indicators was with the use of combined conduction anaesthesia. Thus, the performed study allows to recommend combined regional anesthesia as the method of anesthesia choice, particularly in patients with high anxiety.

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Effect of Deep Anesthesia on Development of Post-Operative Cognitive Dysfunction

Cited by 4 publications

References 14 publications

The problem of choosing anesthesia method for surgical interventions on the lower limbs in young patients

The problem of choosing anesthesia method for surgical interventions on the lower limbs in young patients

Diagnosis of cognitive function changes in patients with abdominal neoplasms occurring in the early postsurgery period and management of those with neuroprotective drug

Dynamics of Stress Laboratory Findings and Their Relation to Psychoemotional State During Regional Anesthesia in Patients With Lower Limbs Injuries

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