Effect of dehydroepiandrosterone treatment on hormone levels and antioxidant parameters in aged rats

Fj, Yin; Kang, Jae-Heon; Nn, Han; Ma, Hongwei

doi:10.4238/2015.september.22.24

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…Dehydroepiandrosterone (DHEA) and the more abundant dehydroepiandrosterone sulfate (DHEAS) are important precursors of the active sex hormones testosterone and estradiol. DHEA has been hypothesized to reverse vascular remodeling, improve vascular endothelial cell function, and reduce oxidative stress (7)(8)(9). Previous studies have shown that, in men, low serum levels of DHEA increase the risk of CHD; however, the relationship between DHEAS and CHD is contradictory (10,11).…”

Section: Introductionmentioning

confidence: 99%

Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus

et al. 2022

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AimsSex hormones play an important role in the pathogenesis of cardiovascular disease (CVD). This cross-sectional study aimed to explore the associations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) with coronary heart disease (CHD) and stroke in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM).Materials and MethodsA total of 995 patients with T2DM were included in the study analysis. Serum levels of DHEA and DHEAS were quantified using liquid chromatography–tandem mass spectrometry. Binary logistic regression analyses were performed to assess the associations of DHEA and DHEAS with CHD and stroke. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal DHEA and DHEAS cutoff values for the detection of CHD in men with T2DM.ResultsIn men with T2DM, after adjustment for potential confounders in model 3, the risk of CHD decreased with an increasing serum DHEA level [odds ratio (OR) = 0.38, quartile 4 vs. quartile 1; 95% confidence interval (CI) = 0.16–0.90; p = 0.037 for trend). Consistently, when considered as a continuous variable, this association remained significant in the fully adjusted model (OR = 0.59, 95% CI = 0.40–0.87, p < 0.05). When taken as a continuous variable in model 3, serum DHEAS level was also inversely related to the risk of CHD among men (OR = 0.56, 95% CI = 0.38–0.82, p < 0.05). Similarly, this relationship remained statistically significant when DHEAS was categorized into quartiles (OR = 0.27, quartile 4 vs. quartile 1; 95% CI = 0.11–0.67; p = 0.018 for trend). ROC curve analyses revealed that the optimal cutoff values to detect CHD in men with T2DM were 6.43 nmol/L for DHEA and 3.54 μmol/L for DHEAS. In contrast, no significant associations were found between DHEA and DHEAS on the one hand and stroke on the other in men and women with T2DM (all p > 0.05).ConclusionsSerum DHEA and DHEAS were significantly and negatively associated with CHD in middle-aged and elderly men with T2DM. This study suggests potential roles of DHEA and DHEAS in CHD pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus

et al. 2022

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“…The body weight gain of perimenopausal rats was significantly more than that noted in young adult rats. However, Yin et al (2015) reported that the change in body weight between the young and old rats is insignificant. On the other hand, DHEA-treated perimenopausal rats gained less body weight than observed in non-treated perimenopausal rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dehydroepiandrosterone on Gross Morphology and Behavior of Perimenopausal Rats

Abo-Zeid

Fares

Mahmoud

et al. 2017

Egyptian Academic Journal of Biological Sciences, B. Zoology

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The current study is designed to detect the potential side effects of therapeutic doses of DHEA among perimenopausal rats MATERIALS AND METHODS Drugs and chemicals: Dehydroepiandrosterone (DHEA ®) capsules were purchased from Puritan's Pride Company, Inc. (USA). Each DHEA capsule is made from active 100 mg of DHEA powder encapsulated in white capsules, authorised by the Medicines and Healthcare ARTICLE INFO ABSTRACT Article History

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“…Of note, DHEA levels present a negative correlation with the NOR index, suggesting a negative action on diabetic encephalopathy. This is quite surprising, since the protective and antioxidant actions of this steroid are well known [ 77 ], even if its actions have been better described during aging [ 78 , 79 ]. Moreover, in this paper, we reported increased hippocampal levels of PREG and PROG that, as stated above, show a similar pattern in plasma.…”

Section: Discussionmentioning

confidence: 99%

Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy

Diviccaro,

Cioffi,

Piazza

et al. 2023

Biomolecules

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The pathological consequences of type 2 diabetes mellitus (T2DM) also involve the central nervous system; indeed, T2DM patients suffer from learning and memory disabilities with a higher risk of developing dementia. Although several factors have been proposed as possible contributors, how neuroactive steroids and the gut microbiome impact brain pathophysiology in T2DM remain unexplored. On this basis, in male Zucker diabetic fatty (ZDF) rats, we studied whether T2DM alters memory abilities using the novel object recognition test, neuroactive steroid levels by liquid chromatography–tandem mass spectrometry, hippocampal parameters using molecular assessments, and gut microbiome composition using 16S next-generation sequencing. Results obtained reveal that T2DM worsens memory abilities and that these are correlated with increased levels of corticosterone in plasma and with a decrease in allopregnanolone in the hippocampus, where neuroinflammation, oxidative stress, and mitochondrial dysfunction were reported. Interestingly, our analysis highlighted a small group of taxa strictly related to both memory impairment and neuroactive steroid levels. Overall, the data underline an interesting role for allopregnanolone and microbiota that may represent candidates for the development of therapeutic strategies.

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Effect of dehydroepiandrosterone treatment on hormone levels and antioxidant parameters in aged rats

Cited by 10 publications

References 36 publications

Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus

Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus

Effects of Dehydroepiandrosterone on Gross Morphology and Behavior of Perimenopausal Rats

Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy

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