Effect of Dendrobium officinale polysaccharides on central nervous system disease: Based on gut microbiota

Xu, Lei; Zeng, Xiaoxiong; Liu, Yanan; Wu, Zufang; Zheng, Xiaojie; Zhang, Xin

doi:10.1016/j.ijbiomac.2023.124440

Cited by 13 publications

(3 citation statements)

References 91 publications

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“…A study altered the gut microbiota structure in mice with colitis by supplementing them with Dendrobium polysaccharides. 18 Beneficial bacteria, such as Bifidobacterium and Lactobacillus, possess immunemodulating and anti-inflammatory properties. Their increased abundance contributes to the production of more anti-inflammatory molecules, aiding in the alleviation of the inflamma-tory response.…”

Section: Introductionmentioning

confidence: 99%

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Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from Dendrobium officinale on acute ethanol-induced gastritis

Zhu,

Xu,

Chen

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

“…Their increased abundance contributes to the production of more anti-inflammatory molecules, aiding in the alleviation of the inflamma-tory response. 16,18 However, there have been few reports discussing the mechanism of DOP gastric protection in vivo.…”

Section: Introductionmentioning

confidence: 99%

Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from Dendrobium officinale on acute ethanol-induced gastritis

Zhu,

Xu,

Chen

et al. 2024

Food Funct.

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“…Polysaccharides are difficult to degrade by enzymes encoded in the human genome. However, Bacteroidetes, Firmicutes, a small amount of Actinobacteria, and Proteobacteria in the intestinal flora can secrete polysaccharide-degrading enzymes to degrade polysaccharides and promote the digestion and absorption of polysaccharides [24,25]. The non-digestible components and fermentation products of polysaccharides can further regulate the composition of intestinal flora, improve intestinal function, and maintain body health [26,27].…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Dendrobium officinale Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice

Qi,

Zhou,

Wang

et al. 2024

Antioxidants

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Background: The discovery of traditional plants’ medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant Dendrobium officinale polysaccharide (DOP) on atherosclerosis is still not elucidated. Purpose: This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE−/−) mice. Study design and methods: The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE−/− mice as an animal model. In the DOP intervention stage, the DOP group was treated by gavage with 200 μL of 200 mg/kg DOP at regular times each day and continued for eight weeks. We detected changes in serum lipid profiles, inflammatory factors, anti-inflammatory factors, and antioxidant capacity to investigate the effect of the DOP on host metabolism. We also determined microbial composition using 16S rRNA gene sequencing to investigate whether the DOP could improve the structure of the gut microbiota in atherosclerotic mice. Results: DOP effectively inhibited histopathological deterioration in atherosclerotic mice and significantly reduced serum lipid levels, inflammatory factors, and malondialdehyde (F/B) production. Additionally, the levels of anti-inflammatory factors and the activity of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased after DOP intervention. Furthermore, we found that DOP restructures the gut microbiota composition by decreasing the Firmicutes/Bacteroidota (F/B) ratio. The Spearman’s correlation analysis indicated that serum lipid profiles, antioxidant activity, and pro-/anti-inflammatory factors were associated with Firmicutes, Bacteroidota, Allobaculum, and Coriobacteriaceae_UCG-002. Conclusions: This study suggests that DOP has the potential to be developed as a food prebiotic for the treatment of atherosclerosis in the future.

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Change in chemical composition and enhancement of intestinal microflora of acid hydrolyzed polysaccharides from Zizyphus jujube and Sterculia lychnophora

Huang,

Chiu,

et al. 2024

Arabian Journal of Chemistry

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Effect of Dendrobium officinale polysaccharides on central nervous system disease: Based on gut microbiota

Cited by 13 publications

References 91 publications

Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from Dendrobium officinale on acute ethanol-induced gastritis

Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from Dendrobium officinale on acute ethanol-induced gastritis

The Antioxidant Dendrobium officinale Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice

Change in chemical composition and enhancement of intestinal microflora of acid hydrolyzed polysaccharides from Zizyphus jujube and Sterculia lychnophora

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