Effect of Dentin Biomodification Using Naturally Derived Collagen Cross-Linkers: One-Year Bond Strength Study

Castellan, Carina Strano; Bedran-Russo, Ana K.; Antunes, Alberto Nogueira da Gama; Pereira, Patrícia

doi:10.1155/2013/918010

Cited by 56 publications

(83 citation statements)

References 29 publications

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“…Proanthocyanidin from grape seed extract is a natural safe compound and works as well as glutaraldehyde (27). Proanthocyanidin extract stabilizes and increases the density of type-I collagen network (26), which improves the dentin mechanical properties and decreases the swelling ratio that may indicate a matrix resistance against enzymatic degradation (11,26). The results of the present study did not show a statistically difference between glutaraldehyde and proanthocyanidin extract at 24 h for all adhesives studied.…”

Section: Discussioncontrasting

confidence: 47%

“…A previous study that evaluated the effect of cross-linking agents (glutaraldehyde and proanthocyanidin extract) on dentin bond strength showed improvement of immediate adhesion, but the stabilization of bonding after long-term storage depended on the adhesive type (11). Dentin biomodification is a biomimetic strategy therapy to enhance the collagen scaffold biomechanically and reduce biodegradability against endogenous and exogenous proteases (9).…”

Section: Discussionmentioning

confidence: 99%

“…Glutaraldehyde and proanthocyanidin-rich grape seed extract were dissolved in deionized water and the pH was adjusted to 7.2 using NaOH at room temperature. Both solutions were applied for 10 min and washed for 3 min prior to adhesives application (11).…”

Section: Microtensile Bond Strengthmentioning

confidence: 99%

“…Studies have shown that these agents improve collagen mechanical properties and reduce their sensitivity to denaturation and degradation (8,9). Two examples of collagen cross-linkers agents are the glutaraldehyde and proanthocyanidin solutions, which have been able to improve dentin collagen stability and bond strength of conventional etch-and-rinse adhesives to dentin (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Dentin Sealing and Bond Strength Evaluation of Hema-Free and Multi-Mode Adhesives to Biomodified Dentin

et al. 2017

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This study evaluated the effect of dentin biomodification on the bond strength (BS) and sealing ability (SA) of HEMA-free and multi-mode adhesives after 24 h and 6 months of water storage. Four adhesives were tested: two multi-mode (Scotchbond Universal -SU, and Prime & Bond Elect -PB) and two HEMA-free (All-Bond 3 -AB, and G-Aenial -GA). Human third molars were selected and dentin was treated with two cross-linking agents (5% glutaraldehyde and 6.5% proanthocyanidin-rich grape seed extract -PACs) for 10 min or kept untreated (control group) (n=6). Teeth were sectioned and prepared for BS test and SA analysis. The SA measurements were taken with the presence of smear layer (minimum permeability), EDTA treatment (maximum permeability), PACs application, adhesive application and after 6 months of water storage. BS data were analyzed by Proc Mixed and Tukey-Kramer test (α=5%). PACs application increased the BS for all adhesives tested at 24 h. However, BS decreased for SU and AB after six months. In general, multi-mode adhesives (SU and PB) did not differ from AB HEMA-free. GA presented the lowest BS values at both times of evaluation. Dentin permeability was reduced after PACs application and remained the same after 6 months, regardless adhesive application. PACs can increase the BS regardless the type of adhesive, however only for PB and GA the BS kept stable after 6-months of water storage. PACs was able to seal the dentin as the minimum permeability and also remained stable after 6 months.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Microtensile Bond Strengthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dentin Sealing and Bond Strength Evaluation of Hema-Free and Multi-Mode Adhesives to Biomodified Dentin

et al. 2017

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“…Higher αTBS were observed for 6.5% grape seed extract (GSE) immediately (SB-62.9MPa; OS-51.9MPa) when compared to 6.5% cocoa seed extract ethanol-water(CSE-ET) (SB-56.95MPa; OS-60.28MPa), 6.5% cocoa seed extract acetone-water(CSE-AC) (SB-49.97MPa; OS-54.44MPa), and distilled water (CO) (SB-52.0MPa; OS-44.0MPa). GSE and CSE-ET agents provided enhanced immediate adhesion and stabilization to demineralized dentin after long-term storage, depending on adhesive system [24].…”

Section: Proanthocyanidin (Grape Seed Extract)mentioning

confidence: 99%

Antioxidants in Endodontics: A Strategic Review

Patel¹

2015

JCDR

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The effect of proanthocyanidin and casein phosphopeptide‐amorphous calcium phosphate on the bond strength durability to caries‐affected dentin

Jowkar

Firouzmandi

Tabibi

2020

Clinical & Exp Dental Res

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Objectives The aim of this study was to evaluate the effect of proanthocyanidin (PA) and casein phosphopeptide‐amorphous calcium phosphate (CPP‐ACP) paste on the micro‐shear bond strength (μSBS) durability of an etch‐and‐rinse adhesive to caries‐affected dentin (CAD). Materials and methods The occlusal surfaces of 80 human molars with occlusal caries were ground to expose flat dentin surfaces with CAD. Then, they were randomly divided into four groups (n = 20) according to the CAD pretreatment. The study groups included no pretreatment, pretreatment with CPP‐ACP for 3 min, pretreatment with PA for 1 min, and pretreatment with PA for 1 min followed by CPP‐ACP for 3 min before adhesive application. After restoring the specimens with composite resin, μSBS testing was performed for half of the bonded surfaces in each group after 24 h and the other half was tested after 6 months of water storage and failure mode analysis was performed. Results The PA group was associated with a higher μSBS than the control and CPP‐ACP groups after 24 hours (p < 0.05). No significant difference was observed regarding the μSBS of the control and the other groups after 24 h (p > 0.05). No significant difference was observed regarding the μSBS of the PA and PA + CPP‐ACP groups (p > 0.05). The μSBS of the 6‐month specimens was significantly lower than those of the 24‐h specimens for all the groups (p < 0.05) except for the PA group which did not exhibit a significant difference between the two times (p > 0.05). The most common type of failure was mixed failure. Conclusion PA pretreatment could stabilize the CAD‐resin interface and protect degradation over time. The same effect was not observed for CPP‐ACP or PA + CPP‐ACP.

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Effect of Dentin Biomodification Using Naturally Derived Collagen Cross-Linkers: One-Year Bond Strength Study

Cited by 56 publications

References 29 publications

Dentin Sealing and Bond Strength Evaluation of Hema-Free and Multi-Mode Adhesives to Biomodified Dentin

Dentin Sealing and Bond Strength Evaluation of Hema-Free and Multi-Mode Adhesives to Biomodified Dentin

Antioxidants in Endodontics: A Strategic Review

The effect of proanthocyanidin and casein phosphopeptide‐amorphous calcium phosphate on the bond strength durability to caries‐affected dentin

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