Effect of desamino‐cholecystokinin‐octapeptide (CCK‐7) on the intraluminal pressure and myoelectrical activity of the gall‐bladder, stomach, and small intestine in conscious dogs

Abstract

Desamino‐cholecystokinin‐octapeptide (CCK‐7) increased the gall‐bladder pressure and decreased the gastric pressure following i.v. infusion in conscious dogs. In small intestine and Heidenhain pouch CCK‐7 exerted an initial excitatory effect followed by an inhibitory effect on intraluminal pressure and peristalsis. In all organs the effect of CCK‐7 on pressure was correlated with a change of spike discharge. CCK‐7 is more potent on gastrointestinal motor activity than a Boots preparation of pancreozymin. The results suggest that CCK‐7 at doses within the physiological range could be involved in the regulation of gastrointestinal motility.