Effects of cholecystokinin and gastrin on gastroduodenal motility and coordination in chickens

Martı́nez, Vicente; Jiménez, Marcel; Goñalons, E.; Vergara, P.

doi:10.1016/0024-3205(93)90139-t

Cited by 28 publications

(10 citation statements)

References 17 publications

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“…This result supports the idea that cG has a weak role in the control of the MMC pattern, although it might participate in the regulation of gastroduodenal motility (Martinez et al, 1993a). In contrast to plasma RIA for CCK, immunohistochemical differentiation of two populations of cells, one containing cG and the other containing a CCK-like peptide, was clearly demonstrated in a previous study (Martinez et al, 1993b).…”

Section: Discussionsupporting

confidence: 86%

“…Unfortunately, this correlation cannot be studied in avian species because the CCK antagonists L-364,718 and L-365,260 are not active in vivo, suggesting some differences between avian CCK receptors and their mammalian counterparts (Campbell et al, 1991;Martinez et al, 1993a).…”

Section: Discussionmentioning

confidence: 92%

“…Chicken gastrin (cG) has recently been isolated from chicken antrum as a molecule showing a CCK-like structure but a gastrin-like biological activity (Dimaline et al, 1986;Dimaline and Lee, 1990). Although CCK has not been isolated from the chicken gut, there is good chromatographical (Dockray, 1979), immunological (Martinez et al, 1993b), and functional (Martinez et al, 1993a) evidence supporting its presence in the chicken intestine. A previous study also demonstrated different actions for CCK and cG in the control of gastroduodenal motility in chickens, supporting the presence of a functional form of CCK in the avian gut (Martinez et al, 1993a).…”

Section: Introductionmentioning

confidence: 97%

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Modulation of the Migrating Myoelectric Complexes by Cholecystokinin and Gastrin in the Gastrointestinal Tract of Chickens

et al. 1995

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Several mammalian avian species, including the chicken, show migrating myoelectric complexes (MMC) both in unfed and fed states. In these species, postprandial hormones seem to modulate but not to disrupt the MMC. To gain more information in this modulatory role, we evaluated the role of cholecystokinin (CCK) vs gastrin on the regulation of intestinal motility in chickens. Birds were implanted with eight electrodes for electromyography in the stomach, duodenum, jejunum, and ileum. In feed-deprived animals, CCK infusion (10(-12) mol/kg per min x 3 h) did not disrupt the MMC but induced changes in the MMC pattern similar to those induced by a meal. Infusion of CCK in fed animals induced dose-dependent effects: CCK infused at 10(-11) and 3 x 10(-11) mol/kg per min x 2 h, progressively elongated the MMC and slowed the speed of propagation of Phase 3. Furthermore, CCK infused at 10(-10) mol/kg per min x 2 h disrupted the MMC but a Phase 3 appeared just after the end of the infusion. By contrast, chicken gastrin (10(-10) mol/kg per min x 2 h) did not modify the MMC pattern. In conclusion, CCK influence on the intestinal motility of chickens ranges from the modulation of the MMC to total disruption, depending on the dose. Moreover, this study suggests that the mechanism of action of CCK could be similar in both mammalian and avian small intestines.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 97%

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Modulation of the Migrating Myoelectric Complexes by Cholecystokinin and Gastrin in the Gastrointestinal Tract of Chickens

et al. 1995

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“…We also anticipate that there would be reduced secretion of bile and pancreatic polypeptides in the high-growth haplotype (39). None of these potential effects are likely to be conducive to more rapid growth; however, the potential to increase the transition of food through the digestive tract (15, 41) could improve growth. Further work using these genotypes will be required to characterize the endocrine and paracrine effects in the gut and how they promote growth.…”

Section: Discussionmentioning

confidence: 99%

Decreased expression of the satiety signal receptor CCKAR is responsible for increased growth and body weight during the domestication of chickens

Dunn

Meddle

Wilson

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Animal domestication has resulted in changes in growth and size. It has been suggested that this may have involved selection for differences in appetite. Divergent growth between chickens selected for egg laying or meat production is one such example. The neurons expressing AGRP and POMC in the basal hypothalamus are important components of appetite regulation, as are the satiety feedback pathways that carry information from the intestine, including CCK and its receptor CCKAR (CCK1 receptor). Using 16 generations of a cross between a fast and a relatively slow growing strain of chicken has identified a region on chromosome 4 downstream of the CCKAR gene, which is responsible for up to a 19% difference in body weight at 12 wk of age. Animals possessing the high-growth haplotype at the locus have lower expression of mRNA and immunoreactive CCKAR in the brain, intestine, and exocrine organs, which is correlated with increased levels of orexigenic AGRP in the hypothalamus. Animals with the high-growth haplotype are resistant to the anorectic effect of exogenously administered CCK, suggesting that their satiety set point has been altered. Comparison with traditional breeds shows that the high-growth haplotype has been present in the founders of modern meat-type strains and may have been selected early in domestication. This is the first dissection of the physiological consequences of a genetic locus for a quantitative trait that alters appetite and gives us an insight into the domestication of animals. This will allow elucidation of how differences in appetite occur in birds and also mammals.

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“…The biological functions of CCK8 in the avian GIT have been extensively studied while those of CCK7 remain undocumented . Intravenous infusion of CCK8 inhibits gastric emptying (Savory et al, 1981) while stimulating duodenal electric activity in a manner that suggests an increase in segmental contractions (Martinez et al, 1993). Increased circulatory levels of CCK8 have been consistently associated with a reduction of voluntary feed intake in chickens (Honda et al, 2017).…”

Section: Expression Of Genes Related To Gut Hormonesmentioning

confidence: 99%

Butyrate in broiler diets : impact of butyrate presence in distinct gastrointestinal tract segments on digestive function, microbiota composition and immune responses

Moquet¹

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Dietary butyrate supplementation has however an inconsistent effect on the growth performance of broilers, with factors such as inclusion level, health status, age of the bird or diet composition being influential for the observed effects on growth performance (Cerisuelo et al., 2014; Polycarpo et al., 2017). Several mechanisms underlying the observed effects of butyrate on growth of livestock have been hypothesised (For review, see Guilloteau et al., 2010). At present, a limited number of studies have investigated the existence of such mechanisms in poultry (Zhang et al., 2011; Liu et al., 2017). In addition, most of the poultry studies resorted to only one butyrate additive and did not report butyrate concentrations along the GIT (e.g. Czerwinski et al., 2012; Cerisuelo et al., 2014). Hence, it remains uncertain whether the effects elicited by butyrate are conditioned by the GIT segment wherein the molecule is present. This dearth of knowledge could limit the full use of butyrate supplements as a nutritional strategy to meet the challenges of the poultry industry. Bacteriostatic and bactericidal effects Butyrate presence in the gastrointestinal tract Intracellular effects Sensing by enteroendocrine cells Increased gut integrity and prevention of inflammation Changes in passage rate, gut morphology and enzymatic secretions Changes in nutrient digestibility Shifts in microbiota composition Changes in immune responses Change in growth performance Figure 1. Putative modes of action of butyrate resulting in changes in the growth performance of broiler chickens Literature review

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Effects of cholecystokinin and gastrin on gastroduodenal motility and coordination in chickens

Cited by 28 publications

References 17 publications

Modulation of the Migrating Myoelectric Complexes by Cholecystokinin and Gastrin in the Gastrointestinal Tract of Chickens

Modulation of the Migrating Myoelectric Complexes by Cholecystokinin and Gastrin in the Gastrointestinal Tract of Chickens

Decreased expression of the satiety signal receptor CCKAR is responsible for increased growth and body weight during the domestication of chickens

Butyrate in broiler diets : impact of butyrate presence in distinct gastrointestinal tract segments on digestive function, microbiota composition and immune responses

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