Effect of Deslorelin and/or Human Chorionic Gonadotropin on Inducing Ovulation in Mares During the Transition Period Versus Ovulatory Season

Gomes, R. G.; Oliveira, R. L.; Schutzer, Carlos Guilherme de Castro; Barreiros, Thales Ricardo Rigo; Seneda, Marcelo Marcondes

doi:10.1016/j.jevs.2014.06.015

Cited by 10 publications

(10 citation statements)

References 12 publications

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“…We had 93.8% of mares treated with BRD ovulate within 48 h of treatment, which is in agreement with another study using a controlled‐release product that reported an ovulation rate of 89.9% at 48 h . Others reported an ovulation rate of 68.8% 48 h after treatment with deslorelin, although it is not clear from that report whether the authors used a similar controlled‐release product . We observed a peak in ovulation 24–48 h after treatment for both deslorelin products, similar to previous studies using Ovuplant or other injectable biorelease formulations of deslorelin …”

Section: Discussionsupporting

confidence: 91%

Comparative efficacy of BioRelease Deslorelin® injection for induction of ovulation in oestrus mares: a field study

Finan

Lamkin²,

McKinnon

2016

Aust Veterinary J

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Section: Discussionsupporting

confidence: 91%

Comparative efficacy of BioRelease Deslorelin® injection for induction of ovulation in oestrus mares: a field study

Finan

Lamkin²,

McKinnon

2016

Aust Veterinary J

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“…The ovulation rate within 48 h is generally considered as an accurate criterion for evaluating the ability of a treatment to induce ovulation [ 62 ]. No differences between ovulation-inducing treatments (hCG and DES) were observed for this parameter, which is consistent with previous studies in mares [ 63 , 64 , 65 , 66 ] and jennies [ 35 ]. However, as previously reported [ 52 ], it seems probable that DES has a better ability to induce ovulation of smaller follicles than hCG and thereby affect their efficacy (DES: 78.7% vs. hCG: 60.9%; p = 0.086).…”

Section: Discussionsupporting

confidence: 92%

“…Our data show similar ovulation rates to previous studies using deslorelin acetate or hCG in mares [ 66 ], but lower than those reported in previous studies using 3000 IU of hCG [ 67 ] or 2.2 mg of deslorelin acetate [ 48 ] in jennies. The recommended dosage for hCG (in mares) is 1500–3000 IU.…”

Section: Discussionsupporting

confidence: 82%

Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate

Bottrel

Ortiz

Hidalgo

et al. 2022

Animals

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Two prostanglandins (luprostiol, LUP, and dinoprost, DIN) and two ovulation-inducing agents (human Chorionic Gonadotropin, hCG, and deslorelin, DES) were evaluated for luteolysis and estrus induction, and for ovulation induction, respectively, in embryo donor jennies. Twenty-six fertile Andalusian jennies were used. In Experiment 1, jennies (n = 112 cycles) were randomly treated with either LUP or DIN after embryo flushing. In Experiment 2, donors (n = 84 cycles) were randomly treated with either hCG or DES to induce ovulation. No differences were found between prostaglandins for all variables studied (prostaglandin–ovulation interval (POI), interovulatory interval (IOI), embryo recovery rate (ERR), positive flushing rate (PFR) and embryo grade (EG)). The ovulation rate was similar for hCG and DES (60.9% vs. 78.7%). However, the interval to ovulation (ITO) was affected (62.61 ± 7.20 vs. 48.79 ± 2.69 h). None of the other variables studied (ERR, PFR and EG) were affected (p > 0.05), except for embryo quality (p = 0.009). In short, both prostaglandins evaluated are adequate to induce luteolysis and estrus. Both ovulation-inducing agents hastened ovulation, but DES seems to be more effective than hCG. Follicular diameter affected the interval from treatment to ovulation, and high uterine edema was related to low embryo quality.

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“…This treatment is often used alongside other management or treatment strategies but can be used as a single treatment assuming that the mare is in late transition and close to cycling spontaneously. There is some suggestion that hCG is more effective in inducing ovulation in the late transitional phase compared to GnRH analogues; however, this is likely to be dose and analogue dependent (Gomes and others 2014, Fanelli and others 2020).…”

Section: Pharmacological Stimulation Of Cyclicitymentioning

confidence: 99%

Update on the management of anoestrus and transitional phase in horses

Crabtree¹

2021

In Practice

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Background: Practitioners are regularly presented with mares in anoestrus or the transitional phase of the reproductive cycle. The first aim for the practitioner is to determine what stage of the cycle the mare is likely in and then determine the likely timescale to spontaneous cyclic activity. If it is desirable for the mare to be bred sooner than this, management and/or pharmacological strategies can be implemented in an attempt to advance cyclic activity.Aim of the article: This article aims to update the practitioner with regard to the current and future methods of management and pharmacological therapies available to stimulate cyclic activity in the mare in anoestrus or transitional phase of the reproductive cycle.

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Effect of Deslorelin and/or Human Chorionic Gonadotropin on Inducing Ovulation in Mares During the Transition Period Versus Ovulatory Season

Cited by 10 publications

References 12 publications

Comparative efficacy of BioRelease Deslorelin® injection for induction of ovulation in oestrus mares: a field study

Comparative efficacy of BioRelease Deslorelin® injection for induction of ovulation in oestrus mares: a field study

Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate

Update on the management of anoestrus and transitional phase in horses

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