Effect of desmethylimipramine on the canine SA node.

Chiba, Shigetoshi

doi:10.1620/tjem.113.337

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…When desipramine at doses of 10-100 pg was injected into the sinus node artery, initially brief negative chronotropic and inotropic effects followed by long-lasting positive effects were produced as previously reported (8,9). These dose levels of desipramine significantly …”

Section: Absence Of Blocking Eff Ct Of Desipramine On Plies}ylepliriisupporting

confidence: 68%

Effect of Diltiazem on the Membrane Potential of Uterine Smooth Muscle

Magaribuchi

Nakajima

1977

Japanese Journal of Pharmacology

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On the other hand, methoxamine usually induced negative chronotropic and inotropic effects in both preparations, and these negative effects were not blocked by atropine, tetrodotoxin and phentolamine. These results suggest that phenylephrine produces a cholinergic excitation which may occur through an adrenergic alpha-mechanism in parasympathetic nerve terminals, in addition to its adrenergic beta-stimulating effect.In 1968, James et al.(1) reported that sinus deceleration with the adrenergic alpha stimulant, methoxamine was prevented by phenoxybenzamine but not by atropine. These workers had directly perfused the sinus node artery of the dog heart in situ (2). They con cluded that this phenomenon was "evidence for alpha receptor depressant activity". The negative chronotropic effect was not however, observed when phenylephrine was adminis perfused atria] preparation of the dog, which allows for a well controlled study of such local mechanisms and perfusion is carried out only through the sinus node artery.In the present study, the isolated canine atria] preparation was employed to determine

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Section: Absence Of Blocking Eff Ct Of Desipramine On Plies}ylepliriisupporting

confidence: 68%

Effect of Diltiazem on the Membrane Potential of Uterine Smooth Muscle

Magaribuchi

Nakajima

1977

Japanese Journal of Pharmacology

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“…Previously Chiba et al (1973) demonstrated that dopamine given into the cannulated sinus node artery induced much longer sinus acceleration than norepinephrine or epinephrine. Then, it was demonstrated in the in situ and isolated atrium preparations that dopamine-induced positive chronotropic and inotropic effects were signfiicantly suppressed by treatment with desmethylimipramine (Chiba et al 1974;Chiba 1975a, b). It was also shown that effects of tyramine on chrono tropism and on inotropism were completely blocked by desmethylimipramine, although desmethylimipramine has cardiac depressant properties by itself (Chiba 1974(Chiba , 1975aChiba et al 1974a).…”

Section: Discussionmentioning

confidence: 99%

“…Then, it was demonstrated in the in situ and isolated atrium preparations that dopamine-induced positive chronotropic and inotropic effects were signfiicantly suppressed by treatment with desmethylimipramine (Chiba et al 1974;Chiba 1975a, b). It was also shown that effects of tyramine on chrono tropism and on inotropism were completely blocked by desmethylimipramine, although desmethylimipramine has cardiac depressant properties by itself (Chiba 1974(Chiba , 1975aChiba et al 1974a). Therefore, positive chronotropic and inotropic responses to octopamine were mainly due to its indirect effect on the heart.…”

Section: Discussionmentioning

confidence: 99%

Pharmacologic analysis of positive chronotropic and inotropic responses to octopamine.

Chiba

1976

Tohoku J. Exp. Med.

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“…In the present study, it was attempted to investigate effects of dopamine, tyramine and norepinephrine on atrial rate and contractility, using the blood perfused, isolated atrium preparation of the dog (Chiba et al 1975a, b) which was originally developed by Chiba et al (1972). Furthermore, these effects were pharmacologically analyzed by use of desmethylimipramine (Chiba 1974), tetrodo toxin (Hashimoto and Chiba 1969) and alprenolol. A preliminary report of part of these results has been published (Chiba 1975).…”

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confidence: 99%