Effect of Desoxycorticosterone on the Colon: Its Relation to the Action of Cation Exchange Resins in Man.

The effect of deoxycorticosterone on the undirectional transfers of sodium and potassium into and out of the dog intestine

“…There is a considerable body of evidence to indicate that the large intestine, as opposed to the small intestine, does alter the absorption or secretion of electrolyte in response to hormonal factors. The administration of deoxycorticosterone to the rat decreases faecal sodium excretion (Berger et al 1951). The administration of 9-a-fluorohydrocortisone to the dog decreases faecal sodium and increases faecal potassium (Poutsiaka, Thomas & Linegar, 1957).…”

“…In man on a high-salt diet, measurements suggest that the administration of deoxycorticosterone decreases stool sodium and increases stool potassium (Relman & Schwartz, 1952), whereas on a normal salt intake, and receiving cation exchange resin by mouth, the administration of deoxycorticosterone acetate reduces the amount of sodium appearing with the resin in the stool (Berger et al 1951). More sodium is removed by the resin from the normal individual than from the oedematous patient, who fails to excrete sodium in the urine in amounts equal to the dietary intake (Berger & Steele, 1952).…”

“…Such Thiry fistulas were prepared in dogs. Sodium retention was induced with deoxycorticosterone acetate, since the abnormal conservation of sodium by the kidney, colon, salivary gland and sweat gland of the oedematous individual may be simulated in normal men by administration of deoxycorticosterone (Conn, 1949;Berger, Quinn & Homer, 1951;White, Entmacher, Rubin & Leiter, 1955). With the use of radio-isotopes the unidirectional fluxes of sodium and of potassium were measured across the mucosa of various segments of the dog intestine before and after the administration of deoxycorticosterone.…”

Suppression of Sodium Excretion by the Colon in Congestive Heart Failure and Cirrhosis of the Liver Demonstrated by the Use of Cation Exchange Resins 1

“…It is well known that desoxycorticosterone diminishes the excretion of sodium by the kidney and the sweat gland (6) and recently it has been demonstrated that desoxycorticosterone also diminishes the excretion of sodium by the salivary gland and the colon (7). There is evidence that the sweat and salivary glands in the patient who is accumulating edema act in a fashion which resembles excessive desoxycorticosterone-like activity (8, 9).…”

Retardation of Sodium Exchange in Dog Erythrocytes by Physiological Concentrations of Aldosterone, in Vitro*

“…Excessive aldosterone output has been shown to be associated with reduced sodium concentrations in sweat and saliva (3). It is probable that this mineralocorticoid, like desoxycorticosterone acetate (DCA) (4), reduces the sodium content of the feces (5). Woodbury and Koch (6) have shown that aldosterone significantly decreases the intracellular sodium concentration in the brain and skeletal muscle of mice.…”