Effect of Dexmedetomidine on Cardiac Surgery-Associated Acute Kidney Injury: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials

Dexmedetomidine for prevention of postoperative pulmonary complications in patients after oral and maxillofacial surgery with fibular free flap reconstruction:a prospective, double-blind, randomized, placebo-controlled trial

“…Studies have proved that DEX could attenuate perioperative stress, inflammation, and protect the immune function of surgical patients [12], and can provide clinically postoperative pulmonary relevant benefits by improving oxygenation and lung mechanics [13,14], all of which may contribute to decreased postoperative complications and improved clinical outcomes. In the last few years, a few clinical trials have evaluated the effect of DEX on PPCs [13][14][15][16][17][18][19]. However, the results of these studies are markedly variable and appear to be underpowered.…”

Optimal Interpretation of Trial Sequential Analysis in Understanding the Effect of Dexmedetomidine on Acute Kidney Injury After Cardiac Surgery

“…None. WE READ with interest the accompanying editorial by Wieruszewski et al 1 that added perspective to the findings by Peng et al 2 in their systemic review and meta-analysis with trial sequential analysis (TSA) of the role of dexmedetomidine (DEX) in the prevention of cardiac surgeryÀassociated acute kidney injury (CS-AKI). Although Wieruszewski et al pointed out many of the accompanying study's strengths, their interpretation of its TSA seemed somewhat counterintuitive.…”

“…7 In addition, insurance companies are shifting toward bundled payments. 2 Therefore, it is worth considering the placement of invasive lines in the preoperative procedure area as opposed to in the operating room for patients undergoing cardiac surgery. This can save operating room time, minimizing the turnover time, maximize operating room efficiency, and possibly translate into low cost and high quality of healthcare.…”

It’s All in the Details: Dexmedetomidine and Acute Kidney Injury After Cardiac Surgery

“…We thank Drs Kashani and Grocott for their interest in the Peng et al study 1 and our accompanying editorial. 2 We agree that the Peng et al study used strong methodology and statistical approach by application of meta-analysis with trial sequential analysis, particularly when considering previous systemic reviews asking a similar question.…”