Effect of Dextran and Hyaluronic Acid on the Development of Postoperative Peritoneal Adhesions in Experimental Animals

Bergqvist, David; Arfors, Karl-E.

doi:10.1159/000127951

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…The dispersion in formation of adhesions ( fig. 1, nondialysed animals) repre sents a drawback, but among other clinically relevant animal models the present one seems to be the most suitable in regard to quantitative assess ment of adhesions [2,[6][7][8],…”

Section: Discussionmentioning

confidence: 93%

Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Lindenberg¹,

Moesgaard²,

Vangsted³

et al. 1982

Eur Surg Res

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The preventive effect of 24 h intermittent peritoneal dialysis on intra-abdominal adhesion formation was investigated in rats. Intraperitoneal adhesions were induced by excision of 1 × 3 cm of the peritoneum and underlying muscle, subsequently closed with interrupted silk sutures. Animals were allocated at random to either postoperative peritoneal dialysis or a control group. Quantitative assessment of adhesions 1 week later showed a significant reduction in rats undergoing peritoneal dialysis (p < 0.01).

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Section: Discussionmentioning

confidence: 93%

Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Lindenberg¹,

Moesgaard²,

Vangsted³

et al. 1982

Eur Surg Res

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“…Following tenotomy of the middle digit flexor profundus tendon of rabbits, hyaluronic acid reduced scarring compared to animals treated with only saline in distinction to saline only [ 15]. However, other investigators found no significant antiad hesion activity using hyaluronic acid in their rabbit ten don experiments [16].…”

Section: Clinical Significancementioning

confidence: 93%

A Pilot Investigation of Poloxamer 407 for the Prevention of Leptomeningeal Adhesions in the Rabbit

Reigel

Bazmi²,

Shih³

et al. 1993

Pediatr Neurosurg

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Leptomeningeal adhesion formation frequently complicates operations and diseases of the central nervous system. Chronic adhesive arachnoiditis may follow intraspinal surgery for disc, tumor, and closure of myelomeningocele, eventually producing pain and declining neurological status of the patient. Reoperation for scar removal is seldom successful as the arachnoidal adhesions reform. Poloxamer 407 (P407) has been shown to reduce postoperative peritoneal adhesion formation in rats and golden hamsters. In a rabbit model, we investigated the potential of P407 to prevent the production of arachnoidal adhesions and nerve root scarring following laminectomy and surgical meningeal injury. The lumbar spinal roots of 8 New Zealand white rabbits were surgically isolated under magnification. One root sleeve axilla was opened and immediately closed with 10-0 suture (control site) and a second root sleeve axilla was opened, P407 injected, and closed with 10-0 suture (treatment site). Five of 7 rabbits treated with P407 and followed for 7–42 days showed no arachnoidal adhesions at the level of the nerve root. Four New Zealand white rabbits had the lamina removed, and the dura over the spinal cord was opened at two sites separated by one to two lumbar segments. At one site P407 was inserted beneath the dura following durotomy, and the other site was opened in a similar fashion and immediately closed without the insertion of P407. There was a 50% reduction in leptomeningeal adhesion formation with the use of P407. P407 may be useful in neurosurgery for the prevention of arachnoidal adhesions.

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“…One of the major problems of pelvic surgery is postoperative adhesions, especially in cases of tubal surgery. Many agents, such as corticosteroids, dextran and hyaluronidase, have been used to prevent this complication (1,2,4,5,(7)(8)(9)(10). The known complications of the intravenous use of dextran, anaphylactic shock (11) and pulmonary edema (3), have been described.…”

Section: Introductionmentioning

confidence: 99%