Effect of diammine silver fluoride on plaque formation by Streptococcus mutans

Suzuki, Toshiyuki; Tsutsumi, Nobuo; Sobue, S; Suginaka, Hidekazu

doi:10.2330/joralbiosci1965.18.268

Cited by 3 publications

(6 citation statements)

References 31 publications

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“…As the duration of the selected laboratory studies was relatively short, the long‐term caries‐arresting effect and the periodicity of the SDF application could not be evaluated. A time limitation was not set for the literature search; there were studies published as early as the 1970s. Some of these early laboratory studies did not present their results in a contemporary format.…”

Section: Discussionmentioning

confidence: 99%

“…The growth of S. mutans, Streptococcus oralis and Lactobacillus casei was reduced after treatment with SDF [23][24][25][26] . SDF also inhibited the adherence of S. mutans to tooth surfaces 27,28 . The minimum inhibitory concentration and minimum bactericidal concentration of SDF for S. mutans were 33.3 lg/ml and 50.0 lg/ml, respectively 29 , showing that SDF was more effective than silver ammonium nitrate and sodium fluoride 23,27 .…”

Section: Records Included For Evaluation (N = 29)mentioning

confidence: 95%

“…A study reported that silver chloride and metallic silver were formed after application of SDF 3 . In addition, SDF appeared to produce calcium fluoride and metallic 27 The visual broth microdilution method was used to determine the MICs of SDF, Ag(NH 3 ) 2 NO 3 and NaF against S. mutans…”

Section: Effects Of Sdf On Mineral Content Of Enamel and Dentinementioning

confidence: 99%

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Mechanisms of silver diamine fluoride on arresting caries: a literature review

Zhao

Gao

Hiraishi

et al. 2018

International Dental Journal

257

196

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Objective: To review the evidence regarding the mechanisms of silver diamine fluoride (SDF) for arresting caries. Methods: A literature search was conducted using the keywords silver diamine fluoride, and its alternative names, in seven databases: PubMed, Embase and Scopus (English); China National Knowledge Infrastructure (Chinese); Bilioteca Virtual em Saude (Portuguese); Biblioteca Virtual en Salud Espana (Spanish); and Ichushi-Web (Japanese). The titles and abstracts were screened. Full texts were retrieved for publications that studied mechanisms of actions of SDF, including its effects on remineralisation of carious lesions and on cariogenic bacteria. Results: A total of 1,123 publications were identified. Twenty-nine articles were included and they investigated the effect of SDF on cariogenic bacteria and dental hard tissues. Eleven studies investigated the antibacterial properties of SDF. They found that SDF was bactericidal to cariogenic bacteria, mainly Streptococcus mutans. It inhibited the growth of cariogenic biofilms on teeth. Twenty studies reported the remineralisation of demineralised enamel or dentine by SDF. They found that mineral loss of demineralised enamel and dentine was reduced after SDF treatment. A highly mineralised surface rich in calcium and phosphate was formed on arrested carious lesions. Four studies examined the effect of SDF on dentine collagen. They found that SDF inhibited collagenases (matrix metalloproteinases and cysteine cathepsins) and protected dentine collagen from destruction. Conclusion: SDF is a bactericidal agent and reduces the growth of cariogenic bacteria. It inhibits demineralisation and promotes the remineralisation of demineralised enamel and dentine. It also hampers degradation of the dentine collagen.

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Section: Discussionmentioning

confidence: 99%

Section: Records Included For Evaluation (N = 29)mentioning

confidence: 95%

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Mechanisms of silver diamine fluoride on arresting caries: a literature review

Zhao

Gao

Hiraishi

et al. 2018

International Dental Journal

257

196

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“…The AgNP-containing formulation was found to be an antibacterial agent equivalent to silver diamine fluoride, but comparatively less cytotoxic and with the possible advantages of not staining teeth like chlorhexidine does. [76] Regardless of the fact that almost all researches on cariogenic bacteria are still done in vitro, a recently carried out controlled clinical trial was done to evaluate the efficacy of a new anticariogenic agent-centered on chitosan-capped AgNPs (3 nm) dissolved in fluoride solution, topically applied to carious teeth with one dose in a year to prevent caries in children. The AgNP formulation was successful in stopping active dentin caries while leaving no staining on the teeth.…”

Section: Antimicrobial Activity Against Cariogenic Pathogensmentioning

confidence: 99%

“…[ 46 ] SDF also inhibited S. mutans adhesion to tooth surfaces. [ 76 ] According to a systematic review of SDF is more efficient than fluoride varnish. In an ex vivo study to investigate the effects of 38% SDF on multi‐species biofilms on cariogenic bacteria, it was discovered that 38% SDF hinders multi‐species cariogenic biofilm formation on carious lesions, thereby reducing the demineralization process.…”

Section: Clinical Evidence For Sdfmentioning

confidence: 99%

The Synergism of Silver and Fluoride: A New Arsenal in Caries Management

Kumar,

2024

Macromolecular Symposia

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Topical anticaries agents are non‐invasive methods to control and prevent dental caries. SDF is a fluoride‐based agent added to the arsenal of caries prevention tools. It has got a lot of attention since its introduction in the 1970s because of its ability to prevent and arrest caries, as well as its excellent antibacterial and anti‐plaque action. SDF reduces acid production by microorganisms, decreases the Streptococcus mutans count, biofilm formation, increases enamel resistance, and promotes dentinal tubule obliteration when applied to the dental surface. SDF also assists in the remineralization of dentin. A biannual application of 38% SDF has been effective at preventing dentin demineralization. This “silver bullet” can be seen as an alternative for caries prevention in special health care needs children which is minimally invasive and safe. Along with the advantages, there are some disadvantages, and work has been carried out to explore the use of silver nanoparticles (SNP) as anticaries agents to shield the teeth from aesthetic damage caused by Silver diamine fluoride. SNPs are identified to have the potential to prevent and inhibit dental caries while not discoloring demineralized dental enamel. SNPs have a greater surface area for interaction with microorganisms than other particles, making them more effective antimicrobial agents. Fluoride combined with SNP solution has a synergistic effect that promotes enamel remineralization while also acting as a bactericidal agent against cariogenic microorganisms. This review aims to bring out the various advantages and disadvantages related to the use of SDF and SNPs to aid in future research.

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Effect of Silver Diamine Fluoride Treatment on Microbial Profiles of Plaque Biofilms from Root/Cervical Caries Lesions

et al. 2019

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Purpose: To assess the effect of silver diamine fluoride (SDF) on microbial profiles present in plaque from root/cervical carious lesions, and its association with caries lesion arrest. Materials and Methods: Twenty patients with at least one soft cavitated root/cervical carious lesion were included. One lesion/patient was randomly selected and treated with 38% SDF. Supragingival plaque samples were harvested at preintervention and 1 month postintervention. Using an MiSeq platform, 16S rDNA sequencing of the V3-V4 regions was used to determine bacterial profiles. Clinical evaluation of lesion hardness was used to evaluate arrest. t tests, principal component analysis (PCA), multidimensional scaling (MDS), and generalized linear models (GLMs) tests were used for statistical comparisons. Results: From a total of 40 plaque samples, 468 probe targets were observed. Although 60% of lesions became hard postintervention, PCA and MDS tests showed no distinct pre- and postintervention groups. In addition, pre- and postintervention differences in diversity (Shannon index) of microbial profiles between patients with and without lesion arrest were not statistically different. A likelihood ratio test for pre- versus postintervention differences within patients, i.e., adjusting for differences between patients using negative binomial GLMs, showed 17 bacterial taxa with significant differences (FDR <0.05). Conclusion: Although 60% of lesions hardened after SDF treatment, this was not directly due to either overall statistically significant differences in microbial profiles or differences in microbial diversity. Nevertheless, there was a trend with some acid-producing species in that their relative abundance was reduced postintervention. The negative binomial GLMs showed 17 bacterial taxa that were significantly different after SDF treatment.

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Effect of diammine silver fluoride on plaque formation by Streptococcus mutans

Cited by 3 publications

References 31 publications

Mechanisms of silver diamine fluoride on arresting caries: a literature review

Mechanisms of silver diamine fluoride on arresting caries: a literature review

The Synergism of Silver and Fluoride: A New Arsenal in Caries Management

Effect of Silver Diamine Fluoride Treatment on Microbial Profiles of Plaque Biofilms from Root/Cervical Caries Lesions

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