Effect of Diamond‐Like Carbon Thin Film Coated Acrylic Resin on Candida albicans Biofilm Formation

Queiroz, José Renato Cavalcanti; Fissmer, S.F.; Koga-Ito, Cristiane Yumi; Salvia, Ana Carolina Rodrigues Danzi; Massi, M.; Sobrinho, Argemiro Soares da Silva; Júnior, Lafayette Nogueira

doi:10.1111/jopr.12029

Cited by 30 publications

(47 citation statements)

References 28 publications

(57 reference statements)

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“…8 Many studies have investigated the role of modified denture surfaces in decreasing the adhesion of C. albicans and minimizing the formulation of biofilms on denture surfaces. 8,10,11,20,38 Most of the previous studies concentrated on polishing and smoothing the different denture base materials and adding antimicrobial reinforcement material, such as nanosilver. 19,31,39 However, the antibacterial impact of zirconia nanoparticles (nano-ZrO 2 ) against C. albicans has not been well addressed.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Therefore, many attempts have been made to reduce C. albicans adhesion and subsequent colonization on the denture base through the use of a variety of antifungal agents, but this treatment method has proven to be a short-term therapy and not always effective. 2,7 Moreover, many approaches to overcoming fungal adhesion to a denture base have been taken, such as surface modification by using different coatings [8][9][10][11] or incorporating an antifungal additive into a PMMA denture base. 11 Denture base fracture while in use is the most frequent problem, and it requires denture replacement or repair.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention

Gad¹,

Al‐Thobity²,

Shahin³

et al. 2017

IJN

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Background Despite drawbacks, cold-cured acrylic resin is still the most common material used in denture repair. Zirconia nanoparticles were among the reinforcements added to increase the strength of the resin. The effect on Candida due to the addition of zirconia nanoparticles to the resin has not been investigated. Purpose The aim of this study was to evaluate the effect of zirconia nanoparticles added to cold-cured acrylic resin on Candida albicans adhesion. Materials and methods A total of 120 acrylic resin specimens with dimensions measuring 22×10×2.5 mm 3 were prepared and divided into two equal groups. One group (repair) comprised heat-polymerized specimens that were sectioned at the center and prepared to create a 2 mm repair area that was repaired with cold-cured resin reinforced with 0% wt, 2.5% wt, 5% wt, and 7.5% wt zirconia nanoparticles. The second group contained intact cold-cured acrylic resin specimens reinforced with 0% wt, 2.5% wt, 5% wt, and 7.5% wt zirconia nanoparticles. Specimens were incubated at 37°C in artificial saliva containing C. albicans , and the effect of zirconia nanoparticles on C. albicans was assessed using two methods: 1) a slide count method and 2) a direct culture test. Variations in the number of living Candida were observed in relation to the different concentrations of zirconia nanoparticles. Analysis of variance (ANOVA) and post hoc Tukey’s tests were performed for data analysis. If the P -value was ≤0.05, then the difference was considered as statistically significant. Results It was found that C. albicans adhesion to repaired specimens was significantly decreased by the addition of zirconia nanoparticles ( P <0.00001) in comparison with the control group. Intact cold-cured groups and groups repaired with cold-cured resin reinforced with 7.5% wt zirconia nanoparticles showed the lowest Candida count. Tukey’s test showed a significant difference between the repaired group and the intact cold-cured group, while the later demonstrated a lower Candida count. Conclusion The addition of zirconia nanoparticles to cold-cured acrylic resin is an effective method for reducing Candida adhesion to repaired polymethyl methacrylate (PMMA) denture bases and cold-cured removable prosthesis. Clinical significance Based on the results of the current study, zirconia nanoparticles have an antifungal effect, which could be incorporated in the repair material for repairing denture bases and in PMMA removable prostheses as a possible approach for denture stomatitis prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention

Gad¹,

Al‐Thobity²,

Shahin³

et al. 2017

IJN

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“…The diamond burs used in the milling process of the ceramic and composite resin and blocks result in a rougher surface, which may facilitate the retention of microbial film and the consequent inflammation of the periodontal tissue when it is located close to the gingival area. In addition, rougher surfaces facilitate discoloration, decrease the resistance of the restoration, and cause wear of the opposing dentition when the roughness is located in the occlusal region .…”

Section: Introductionmentioning

confidence: 99%

The effect of milling and postmilling procedures on the surface roughness ofCAD/CAMmaterials

Mota

Smidt

Fracasso

et al. 2017

J Esthet Restor Dent

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“…PMMA denture bases coated with thin film of DLC could be an alternative treatment option for the prevention of denture stomatitis. 52…”

Section: Diamond-like Carbon(dlc) Thin Filmmentioning

confidence: 99%

Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis

Ahmad

Jafri

Khan

2020

Journal of Oral Biology and Craniofacial Research

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The purpose of this study is the prevention of Candida colonies on PMMA Denture Base by altering the surface and incorporations of Nanoparticles. Materials and methods: The Pub Med/Medline was searched to identify 100 relevant studies published from 2011 to 2020. The search strategy employed the following keywords related to "use of Nanoparticles in dentistry", "Antimicrobial agents and PMMA", "Candidiasis and nanomaterials", "Prevention of oral Candidiasis", "Incorporation of antimicrobial agents in acrylic dentures," "nanoparticles as therapeutic agents for denture stomatitis", "Nanodentistry" or "Nanotechnology" or "Nanocomposite" or "Nanodrugs" or "Nanomaterials". Results: Most of the studies shows that modified PMMA denture base resin containing different antimicrobial coatings and incorporation of metal oxides Nanoparticles and other nanomaterials showed antifungal activity in vitro; however some materials in higher concentration showing altered physical and mechanical properties possibly due to aggregation of Nanoparticles in the lattice of PMMA molecules. Conclusion: Metal oxides nanomaterials revealed cytotoxicity to Candida and other microbes present in oral biofilm including PMMA denture surface. Nano toxicity may attribute to direct interaction of nanoparticles with cell membrane, hindrance in protein synthesis and early adhesion & interfere with physiology of pathogens.

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Effect of Diamond‐Like Carbon Thin Film Coated Acrylic Resin on Candida albicans Biofilm Formation

Abstract: Diamond-like carbon films, doped or undoped with silver nanoparticles, coating the base of PMMA-based dentures could be an alternative procedure for preventing candidosis in denture users.

Cited by 30 publications

References 28 publications

Inhibitory effect of zirconium oxide nanoparticles on <em>Candida albicans</em> adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention

Inhibitory effect of zirconium oxide nanoparticles on <em>Candida albicans</em> adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention

The effect of milling and postmilling procedures on the surface roughness ofCAD/CAMmaterials

Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis

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