Effect of Diazinon, an Organophosphate Insecticide, on Plasma Lipid Constituents in Experimental Animals

Abstract

There has been increasing interest in studying the various effects of organophosphate insecticides in humans and experimental animals. Only a few data are available on the effect of the organophosphate insecticide, diazinon, on lipid metabolism. The aim of this study was to evaluate the effect of diazinon on plasma lipid constituents in mammalian animals. The plasma levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and phospholipids (PL) were measured in albino rats that were orally treated with a single dose of diazinon at a level of LD(50) or with repeated daily doses at the levels of 1/2, 1/8, and 1/32 LD(50) for 2, 8, and 32 days, respectively. After a 24 h post-treatment with a single LD(50) dose of diazinon, TC was not significantly changed, the HDL-C and PL levels were significantly decreased, but the LDL-C and TG levels were significantly increased. Separate daily oral administrations of diazinon at 1/2 LD(50), 1/8 LD(50), and 1/32 LD(50) doses resulted in a significant decrease in HDL-C and PL, with no significant change in TG. The LDL-C levels were significantly increased and TC showed no significant change with 1/2 LD(50) and 1/32 LD(50) doses of diazinon, whereas a significant decrease in the levels of TC, HDL-C, as well as LDL-C, was observed with the 1/8 LD(50) dose. These data suggest that diazinon may interfere with lipid metabolism in mammals.

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

“…These may be attributed to the increased fat catabolism in response to LCT. 50 Our results also showed a significant increase of serum bilirubin level in LCT intoxicated rats. The increased level of total bilirubin in treated female rats is an indicator of hyper-bilirubinemia, a useful indicator of hepatocellular dysfunction.…”

“…(1/11 th LD 50 ) in female rat (Figure 1). No differences in food and water consumption were seen in last consecutive four days of treatment in the experimental schedule but there was little non-significant alterations observed in food consumption at the exposure dose levels of 1/4 th and 1/3 rd LD 50 .…”

Vitamin C Alleviates Chronic Chlorpyrifos Induced Alterations in Serum Lipids and Oxidative Parameters in Male Wistar Rats

“…Similarly, low-HDL-c has also been reported in rats dosed repeatedly with diazinon (Ibrahim and El-Gamal, 2003). HDL, which is mainly synthesized in the liver and intestinal cells plays an important role in cholesterol efflux from tissues and carries it back to the liver for removal as bile acids (Shakoori et al, 1988).…”

“…Studies have partly implicated oxidative stress in the molecular mechanism of CPFinduced hepatotoxicity (Goel et al, 2005;Ambali et al, 2007;. A number of studies have shown alterations in lipid profiles following OP exposure (McGill et al, 1981;Quistad et al, 2001;Ibrahim and El-Gamal, 2003;El-Banna et al, 2009;El-Mazoudy et al, 2011). However, studies involving the mitigation of OP induced alterations of lipid profiles by readily available and cheap antioxidant molecules such as vitamin C become essential in the light of the current environmental and health challenges posed by OP insecticides.…”

Dichlorvos Exposure Aggravates Complications Associated with Diabetes in Wistar Rats

“…Organophosphates, including DDVP have already been reported to elevate plasma triglyceride [27,28]. The elevated plasma triglyceride concentration may be attributed to DDVP induced inhibition of lipoprotein lipase.…”