Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels

Romero-Navarro, Guillermo; López-Aceves, Teresita; Rojas-Ochoa, Alberto; Mejia, Cristina Fernandez

doi:10.1016/j.lfs.2005.06.010

Cited by 45 publications

(31 citation statements)

References 50 publications

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“…In another study (81), hepatic malate dehydrogenase involved in the citric acid cycle and gluconeogenesis was downregulated in rats exposed to a sub-lethal dose of diazinon. OPs also seem to lower glucokinase, a liver enzyme contributing to glycogen synthesis, as reported for dichlorvos exposure (82). All of these studies indicated changes in carbohydrate metabolism, but their inconsistencies may be owed to the type of the investigated OP, route of administration, as well as animal species and strain.…”

Section: Possible Effects Of Ops On Hepatic Carbohydrate Lipid and mentioning

confidence: 82%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management.

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Section: Possible Effects Of Ops On Hepatic Carbohydrate Lipid and mentioning

confidence: 82%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…2). Other OPCs, including dichlorvos [69] (Table 1) and formothion [70], have previously been reported to have hyperglycaemic effects, but molecular and mechanistic evidence is still missing.…”

Section: Organophosphorus Compoundsmentioning

confidence: 99%

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

et al. 2011

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The prevalence of diabetes mellitus is currently at epidemic proportions and it is estimated that it will increase even further over the next decades. Although genetic predisposition and lifestyle choices are commonly accepted reasons for the occurrence of type 2 diabetes, it has recently been suggested that environmental pollutants are additional risk factors for diabetes development and this review aims to give an overview of the current evidence for this. More specifically, because of the crucial role of pancreatic beta cells in the development and progression of type 2 diabetes, the present work summarises the known effects of several compounds on beta cell function with reference to mechanistic studies that have elucidated how these compounds interfere with the insulin secreting capacity of beta cells. Oestrogenic compounds, organophosphorus compounds, persistent organic pollutants and heavy metals are discussed, and a critical reflection on the relevance of the concentrations used in mechanistic studies relative to the levels found in the human population is given. It is clear that some environmental pollutants affect pancreatic beta cell function, as both epidemiological and experimental research is accumulating. This supports the need to develop a solid and structured platform to fully explore the diabetes-inducing potential of pollutants.

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“…Dichlorvos is a mutagen and a suspected carcinogen for human beings [35]. It has been reported that human exposure to dichlorvos leads to the disorder of glucose metabolism and causes hyperglycaemia [36]. The use of malathion is also of concern as apart from its own neurotoxic effects the associated products contain other cholinesterase inhibitors [37].…”

Section: Introductionmentioning

confidence: 99%

Pesticide degradation in water using atmospheric air cold plasma

Sarangapani¹,

Misra²,

Milosavljević³

et al. 2016

Journal of Water Process Engineering

197

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a b s t r a c tA high voltage dielectric barrier discharge plasma reactor using atmospheric air as the inducer gas was studied for the degradation of pesticides (dichlorvos, malathion, endosulfan) in water. The degradation kinetics of the pesticides were studied using GC-MS as a function of plasma control parameters. Electrical characterisation of the plasma revealed that the plasma discharge consisted of filamentary streamers. Excited nitrogen, reactive oxygen species and OH radicals generated in the dielectric barrier discharge (DBD) plasma reactor were identified using optical emission spectroscopy. Ozone, used as an indicator for metastable oxygen species, was quantified within the reactor at concentrations of 1600, 2200, 2800 ppm after 8 min of plasma treatment for applied voltages of 60, 70, and 80 kV respectively. The degradation efficacy of pesticides after 80 kV and 8 min of plasma treatment were found to be 78.98 ± 0.81% for dichlorvos, 69.62 ± 0.14% for malathion and 57.71 ± 0.58% for endosulfan. Degradation was found to follow first order kinetics. GC-MS analyses showed that the degraded compounds and intermediates formed were less toxic than the parent pesticide. A proposed mechanism of degradation of these pesticides is suggested.

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Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels

Cited by 45 publications

References 50 publications

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

Pesticide degradation in water using atmospheric air cold plasma

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