Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

Paśko, Paweł; Bartoń, H.; Zagrodzki, Paweł; Izewska, Aleksandra; Krośniak, Mirosław; Gawlik, Maciej; Gorinstein, Shela

doi:10.1007/s11130-010-0164-6

Cited by 95 publications

(54 citation statements)

References 24 publications

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“…Previous studies [5] observed that bioactive compound of Quinoa could change antioxidant status in the organism by preventing oxidative stress and also helps reduce the risk of various chronic diseases risk such as anti-inflammatory, immunomodulatory, and anticarcinogenic [6].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Saxena

Shahani

Bhatnagar

2017

Asian J Pharm Clin Res

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Objective:To study the effect of Quinoa seed on carbon tetrachloride (CCL 4 )-induced liver toxicity in Swiss albino male mice. Methods:Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl 4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl 4 -treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted. Results:The results showed that the treatment with Quinoa seed powder significantly reduced CCl 4 -induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies. Conclusion:Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl 4 -induced liver damage in Swiss albino male mice.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Saxena

Shahani

Bhatnagar

2017

Asian J Pharm Clin Res

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“…Measures of lipid peroxidation between the two studies were in complete contrast. The inclusion of quinoa in the diet resulted in a decrease in lipid peroxidation by between 29.6% and 66.1% [23] but also a 21% to 50% increase in peroxidation compared to the control group [26].…”

Section: Resultsmentioning

confidence: 87%

“…Plasma lipid peroxidation was decreased while the expression of antioxidant compounds such as glutathione peroxidase and catalase were elevated in several organs [23]. This suggests that quinoa has the ability to regenerate antioxidant species that can then attack free radicals and therefore protect tissues against oxidative damage.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Physiological Effects Associated with Quinoa Consumption and Implications for Research Involving Humans: a Review

Simnadis

Tapsell

Beck

2015

Plant Foods Hum Nutr

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Quinoa is a pseudo-grain consumed as a dietary staple in South America. In recent years, consumer demand for quinoa in the developed world has grown steadily. Its perceived health benefits have been cited as a driving force behind this trend, but there are very few human studies investigating the impact of quinoa consumption. The aim of this review was to identify physiological effects of quinoa consumption with potential for human health. A critical evaluation of animal model studies was conducted. The quality of identified studies was assessed using a methodological quality assessment tool and summative conclusions were drawn to guide the direction of future human research. The majority of studies were of fair quality. Purported physiological effects of quinoa consumption included decreased weight gain, improved lipid profile and improved capacity to respond to oxidative stress. These physiological effects were attributed to the presence of saponins, protein and 20-hydroxyecdysone in the quinoa seed. The implications of these findings are that human studies should investigate the impact of quinoa consumption on weight gain and lipid levels. The role of quinoa as an antioxidant is still unclear and requires further elucidation in animal models. Disciplines Medicine and Health Sciences | Social and Behavioral Sciences AbstractQuinoa is a pseudo-grain consumed as a dietary staple in South America. In recent years, consumer demand for quinoa in the developed world has grown steadily. Its perceived health benefits have been cited as a driving force behind this trend, but there are very few human studies investigating the impact of quinoa consumption.The aim of this review was to identify physiological effects of quinoa consumption with potential for human health. A critical evaluation of animal model studies was conducted. The quality of identified studies was assessed using a methodological quality assessment tool and summative conclusions were drawn to guide the direction of future human research. The majority of studies were of fair quality. Purported physiological effects of quinoa consumption included decreased weight gain, improved lipid profile and improved capacity to respond to oxidative stress. These physiological effects were attributed to the presence of saponins, protein and 20-2 hydroxyecdysone in the quinoa seed. The implications of these findings are that human studies should investigate the impact of quinoa consumption on weight gain and lipid levels. The role of quinoa as an antioxidant is still unclear and requires further elucidation in animal models.

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“…In the main, this involves monitoring the activities of antioxidant enzymes or antioxidant molecules within the experimental animal on feeding with the grain of interest (Hegde et al, 2005;Pasko et al, 2010a;Moraes et al, 2012;Lee et al, 2013). It is generally accepted therefore that oxidative stress is a precursor for the development of various chronic and degenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Increasing the utilisation of sorghum, millets and pseudocereals: Developments in the science of their phenolic phytochemicals, biofortification and protein functionality

Taylor

Belton

Beta

et al. 2014

Journal of Cereal Science

144

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There is considerable interest in sorghum, millets and pseudocereals for their phytochemical content, their nutritional potential and their use in gluten-free products. They are generally rich in a several phenolic phytochemicals. Research has indicated that the phenolics in these grains may have several important health-promoting properties: prevention and reduction of oxidative stress, anti-cancer, anti-diabetic, anti-inflammatory, anti-hypertensive and cardiovascular disease prevention. However, increased research on the actual healthpromoting properties of foods made from these grains is required. Biofortified (macro-and micronutrient enhanced) sorghum and millets are being developed through conventional breeding and recombinant DNA technology to combat malnutrition in developing countries.Enhanced nutritional traits include: high amylopectin, high lysine, improved protein digestibility, provitamin A rich, high iron and zinc, and improved mineral bioavailability through phytate reduction. Some of these biofortified cereals also have good agronomic characteristics and useful commercial end-use attributes, which will be important to their adoption by farmers. Knowledge of the structure of their storage proteins is increasing.Drawing on research concerning maize zein, which shows that it can produce a visco-elastic wheat-like dough, it appears that the storage proteins of these minor grains also have this potential. Manipulation of protein β-sheet structure seems critical in this regard.3

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Effect of Diet Supplemented with Quinoa Seeds on Oxidative Status in Plasma and Selected Tissues of High Fructose-Fed Rats

Cited by 95 publications

References 24 publications

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Physiological Effects Associated with Quinoa Consumption and Implications for Research Involving Humans: a Review

Increasing the utilisation of sorghum, millets and pseudocereals: Developments in the science of their phenolic phytochemicals, biofortification and protein functionality

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