Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: The Rotterdam Study

Yazdanpanah, Nahid; Zillikens, M. Carola; Rivadeneira, Fernando; Jong, R. de Josselin de; Lindemans, Jan; Uitterlinden, André G.; Pols, Huibert A. P.; Meurs, Joyce B. J. van

doi:10.1016/j.bone.2007.08.021

Cited by 74 publications

(58 citation statements)

References 32 publications

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“…A visible increase in cell growth, in the culture medium treated with cobalamin, was also reported by Kim et al 10 , correlating hypovitaminosis B with the incidence of osteoporosis. This piece of data suggests that cobalamin could have a positive influence on osteoblast activity, as also observed by Stone et al 11 , McLean et al 23 and Yazdanpanah et al 25 . With the isolated administration of cobalamin to the MC3T3 osteoblastic cells, in both culture media, it was noted that cell development and growth continued to be similar to the other samples analyzed when the cells were counted in the Neubauer chamber.…”

Section: Discussionsupporting

confidence: 74%

In vitro evaluation of the effects of risedronate associated with cobalamin on osteoblastic cells

Fiuza

Martinez

Brito

2015

RGO, Rev. Gaúch. Odontol.

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ObjectiveTo evaluate the action of risedronate and cobalamin, and effects when associated, when administered osteoblastic cells. Methods Results The results showed that the growth curve for cell proliferation and the formation of mineral nodules was similar for both cultures analyzed. Conclusion RESUMO ObjetivoAvaliar a ação do risedronato e da cobalamina, e seus efeitos quando associados, em células osteoblásticas. MétodosCélulas MC3T3 foram cultivadas em meio α-MEM e α-MEM suplementado com fatores mineralizantes, ácido ascórbico e α-glicerofosfato dissódico, e tratadas com: risedronato, cobalamina, e risedronato associado à cobalamina na concentração de 10 -3 M. A proliferação celular e formação de nódulos de cálcio e fosfato foram avaliados após 24 horas, 48 horas, 72 horas, 5 dias e 7 dias, através de contagem em Câmara de Neubauer, vermelho de Alizarina e Reação de von Kossa. ResultadosOs resultados mostraram que não houve diferenças significativas na curva de crescimento e formação de nódulos minerais entre as culturas analisadas. ConclusãoConcluiu-se que a utilização do risedronato, da cobalamina e associação de ambas em cultura de células osteoblásticas, não provocaram alterações no crescimento e formação de nódulos de cálcio e fosfato.Termos de indexação: Vitamina B12. Osteoblastos. Osteoporose. In vitro evaluation of the effects of risedronate associated with cobalamin on osteoblastic cellsAvaliação in vitro dos efeitos do risedronato associado à cobalamina sobre células osteoblásticas

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Section: Discussionsupporting

confidence: 74%

In vitro evaluation of the effects of risedronate associated with cobalamin on osteoblastic cells

Fiuza

Martinez

Brito

2015

RGO, Rev. Gaúch. Odontol.

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“…In the past decade, numerous large observational studies have provided evidence to support a role for homocysteine and/or low B-vitamin status in fracture risk (Table 1) (12,(29)(30)(31)(32)(33)(34)(35)(36)(37) . In 2004, two landmark studies performed in the Netherlands and the USA produced consistent findings in terms of the magnitude of increased risk of fracture associated with mild elevations in homocysteine (36,37) .…”

Section: Evidence From Observational Studiesmentioning

confidence: 99%

“…Most recently, a doseresponse meta-analysis including eight observational studies and 11 511 participants estimated a 4 % increase in fracture risk for every 1 μmol/l increase in homocysteine concentration (12) . Given the close metabolic relationship of the B-vitamins with homocysteine, studies have also demonstrated inverse associations between the status of the B-vitamins, folate, vitamins B 12 and B 6 and fracture risk in large cohorts of men and women (29,(33)(34)(35) .…”

Section: Evidence From Observational Studiesmentioning

confidence: 99%

B-vitamins and bone in health and disease: the current evidence

et al. 2014

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Osteoporosis, a metabolic skeletal disease characterised by decreased bone mass and increased fracture risk, is a growing public health problem. Among the various risk factors for osteoporosis, calcium and vitamin D have well-established protective roles, but it is likely that other nutritional factors are also implicated. This review will explore the emerging evidence supporting a role for certain B-vitamins, homocysteine and the 677C→T polymorphism in the gene encoding the folate-metabolising enzyme methylenetetrahydrofolate reductase, in bone health and disease. The evidence, however, is not entirely consistent and as yet no clear mechanism has been defined to explain the potential link between B-vitamins and bone health. Coeliac disease, a common condition of malabsorption, induced by gluten ingestion in genetically susceptible individuals, is associated with an increased risk both of osteoporosis and inadequate B-vitamin status. Given the growing body of evidence linking low bone mineral density and/or increased fracture risk with low B-vitamin status and elevated homocysteine, optimal B-vitamin status may play an important protective role against osteoporosis in coeliac disease; to date, no trial has addressed this possible link.

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“…In this study, the vitamin B2 intake was significantly higher in the school-lunch group than that in the box-lunch group for both sexes. Yazdanpanah et al concluded that increased dietary vitamin B2 intake was associated with higher femoral neck bone mineral density (27). Therefore, the vitamin B2 supplemented in the school lunches, may help in bone growth.…”

Section: Discussionmentioning

confidence: 99%

Effects of the National School Lunch Program on Bone Growth in Japanese Elementary School Children

Kohri

Kaba

Itoh

et al. 2016

J Nutr Sci Vitaminol

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SummaryThe Japanese school lunch program with milk was designed to supply 33-50% of the necessary nutrients per day and 50% of the recommended dietary allowance for calcium, which is difficult to obtain from Japanese meals. Although this program contributes to the mental and physical development of children, the effect of these meals on the bone growth in children remains unknown. Therefore, we compared the effect of school lunch with milk on bone growth between elementary school children attending schools that did not enforce the school lunch with milk program (box-lunch group) and those attending schools that did enforce the program (school-lunch group). The study subjects included fourth-grade children during the 2009-2013 school years, of whom 329 children were in the school-lunch group and 484 children in the box-lunch group. The bone area ratio of the right calcaneus was evaluated using quantitative ultrasound (Benus III). Dietary intakes were assessed using brief self-administered diet history questionnaires. The subjects were asked to record their activities for 3 d so that the mean physical activity intensity and the time spent sleeping could be estimated. The bone area ratios (%) were significantly higher in the school-lunch group than in the box-lunch group (males 31.060.3 vs. 30.360.2; females 30.660.2 vs. 29.760.2). This tendency did not change even after adjustment for confounding factors associated with bone growth. The results suggest that nutrients supplied by the Japanese school lunch program contributed to increased bone growth in elementary school children.

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Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: The Rotterdam Study

Cited by 74 publications

References 32 publications

In vitro evaluation of the effects of risedronate associated with cobalamin on osteoblastic cells

In vitro evaluation of the effects of risedronate associated with cobalamin on osteoblastic cells

B-vitamins and bone in health and disease: the current evidence

Effects of the National School Lunch Program on Bone Growth in Japanese Elementary School Children

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