Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs

Han, Xinyan; Xu, Zhenghao; Wang, Y. Z.; Tao, Xian-guo; Li, W. F.

doi:10.5713/ajas.2004.1007

Cited by 6 publications

(4 citation statements)

References 42 publications

(48 reference statements)

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“…Similar associations between Cd, Cu and Zn have been reported previously in the literature in a wide variety of animal species exposed both to high and low environmental Cd levels (Spierenburg et al, 1988;Ló pez-Alonso et al, 2004), and are assumed to be a consequence of the shared ability of these metals to induce MT synthesis and compete for the cation-binding sides of MT (Webb, 1979). In pigs, experimental studies have demonstrated that animals fed a diet containing 10 mg/kg Cd show higher Cu content in most tissues and significantly higher Zn content in the kidney than control animals (Han et al, 2004). Conversely, Cu and Zn supplementation of pig diets can affect tissue Cd deposition.…”

Section: Resultsmentioning

confidence: 98%

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

López‐Alonso¹,

Benedito²,

García‐Vaquero³

et al. 2012

Livestock Science

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a b s t r a c tThis study investigated the involvement of metallothionein (MT) in hepatic and renal cadmium (Cd) accumulation and the interactions of this element with the essential elements copper (Cu) and zinc (Zn) in pigs receiving diets with or without Cu and Zn supplementation, in intensive and extensive production systems respectively. Animals from intensive systems showed significantly higher Cd concentrations in the liver (83.3 mg/ kg wet weight) and kidney (343 mg/kg) than animals from extensive systems (33.2 and 130 mg/kg respectively). Cu (liver 16.9, kidney 5.52 mg/kg) and Zn (82.8 and 29.7 mg/kg) concentrations were also significantly higher in pigs from intensive than in animals from extensive systems (Cu 10.1 and 4.64 mg/kg, Zn 66.2 and 23.1 mg/kg). Pigs from intensive systems showed 50% higher kidney MT concentrations than animals from extensive systems (278 and 183 mg/kg respectively), whereas liver MT concentrations were very similar in the two groups (1696 and 1517 mg/kg respectively). MT concentrations in both the liver and the kidney were strongly dependent on the Zn status of the animal. In the liver neither Cu nor Cd displaced Zn from MT, and the proportion of MT binding sites apparently occupied by Cu and Cd decreased with increasing hepatic MT concentration, despite the fact that both Cu and Cd have higher affinity for MT than Zn. The proportion of MT binding sites occupied by Cu and Cd was also directly related to Zn:Cu ratio in hepatic cells. In the kidney, in contrast, Cu seems able to compete with Zn for MT binding sites, and the proportion of MT binding sites occupied by Cu increased with increasing renal MT concentration.

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Section: Resultsmentioning

confidence: 98%

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

López‐Alonso¹,

Benedito²,

García‐Vaquero³

et al. 2012

Livestock Science

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“…However, body weight, liver weight, and the ratio of the femur weight to length were not affected by dietary cadmium when mallard (Anas platyrhynchos) ducklings were fed 20 mg/kg cadmium for 12 weeks, but kidney lesions were evident (Cain et al, 1983). In another study, the body weight of pigs was decreased by 10 mg/kg cadmium (Han et al, 2004).…”

Section: Discussionmentioning

confidence: 95%

“…Myoglobin is a metalloprotein composed of globin and an iron-containing haem prosthetic group. The decrease of myoglobin content in muscle may result from the decrease of iron levels in the body caused by cadmium (Han et al, 2004). Another possible reason is that the synthesis of haem in mitochondr a, may have been disturbed by cadmium, interfering with the production of myoglobin.…”

Section: Discussionmentioning

confidence: 97%

Effect of Cadmium in Feed on Organs and Meat Colour of Growing Pigs

Han

et al. 2007

Vet Res Commun

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One hundred and ninety-two barrows (Duroc x Landrace x Yorkshire, initial weight 27.7 kg) were used to investigate the effects of cadmium in feed on the function of selected organs and meat colour of growing pigs. The pigs were randomly allocated into four different treatments. Each treatment included three replications with 16 pigs per replicate. The animals were fed corn-soybean basal diet and supplemented with 0, 0.5, 5.0, 10.0 mg/kg cadmium (as CdCl(2)), respectively. The feeding trial ended when the average body weight of the pigs reach 90 kg. The results showed that, compared with controls, addition of 10 mg/kg cadmium to the diet resulted in significant elevations of relative weight of liver and spleen by 18.3% (p<0.05) and 19.7% (p<0.05) respectively, and of serum glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities by 17.8% (p<0.05) and 27.4% (p<0.05) respectively; and significant decreases of Na(+)/K(+)-ATPase activity in the liver by 24.6% (p<0.05), the redness of longissimus dorsi by 26.6% (p<0.05) and 24.9% (p<0.05) at 0.75 h and 16 h post mortem, respectively, and of the myoglobin content of longissimus dorsi by 19.4% (p<0.05). No changes were found in these indices above when the pigs were fed the diet supplied with 0.5 or 5 mg/kg cadmium (p>0.05), nor in renal functions among cadmium-treatment treatments (p>0.05) as indicated is the activities of urinary N-acetyl-beta-D-glucosaminidase (NAG) and alkaline phosphatase (ALP) and the content of urinary protein. The study indicated the adverse effects of 10 mg/kg cadmium in feed on liver functions and meat colour of growing pigs.

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“…However, the mechanism involved is not clear. The decrease of apparent digestibility of nutrients may be one of the reasons as shown in barrows (Han et al., 2004), and the change of endocrine function resulted from cadmium accumulation in body may also be the one responsible for this adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of cadmium on serum sex hormone levels in pigs

Han

Wang

et al. 2006

Animal Physiology Nutrition

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An inhibition of sex hormone secretion is observed in domestic animals exposed to cadmium in experimental conditions. Ninety-six gilts (Duroc x Landrace x Yorkshire, initial weight 27.59 kg) were randomly assigned into four different groups with three replications in each group (eight gilts per replication). The groups received the corn-soybean basal diet and supplemented with 0, 0.5, 5.0 and 10.0 mg/kg cadmium (as CdCl2) respectively. The feeding trial was ended when body weight of pigs was approximately 90 kg. The results showed that 10.0 mg/kg cadmium significantly decreased average daily gain (p < 0.05) and increased feed/gain ratio (p < 0.05) of pigs. Follicle-stimulating hormone, luteinizing hormone, oestradiol (E2) and progesterone levels in serum of the pigs fed the diet supplemented with 10.0 mg/kg cadmium were lower significantly than those of the control (p < 0.05). Compared with the control, no changes were found in the levels mentioned above when the pigs fed the diet supplemented with 0.5 or 5.0 mg/kg cadmium (p > 0.05). The changes of regulatory mechanism of the pituitary-ovary axis may be the result of cadmium accumulation in pituitary and ovary and should be investigated further.

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Effect of Dietary Cadmium Levels on Nutrient Digestibility and Retention of Iron, Copper and Zinc in Tissues of Growing Pigs

Cited by 6 publications

References 42 publications

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

Effect of Cadmium in Feed on Organs and Meat Colour of Growing Pigs

Effects of cadmium on serum sex hormone levels in pigs

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