Effect of dietary combinations on plaque pH recovery after the intake of pediatric liquid analgesics

Abstract

Objectives:To study the effect of water, halloumi cheese and sugar-free (SF) chewing gum on plaque pH recovery after the intake of sweetened PLAs.Settings and Design:A randomized clinical trial was conducted on 17 children (10 females, 7 males) aged 11–12 years with DFT/dft of more than 3.Materials and Methods:Each volunteer tested paracetamol and ibuprofen suspension alone or followed with water, halloumi cheese or SF gum, as well as 10% sucrose and 10% sorbitol as controls. Plaque pH was measured using the sampling method before and after 5, 10, 15, 20, 30 min of ingestion.Statistical Analysis:Statistical analysis was performed using analysis of variance followed by least significant difference test to assess minimum pH (min pH), maximum pH drop (ΔpH), and the area under baseline pH, and P value was set as 0.05.Results:Both ibuprofen and paracetamol were not significantly different from 10% sucrose in terms of min pH, ΔpH, and area under baseline pH except for min pH of ibuprofen (P = 0.034). Water and halloumi cheese did not have a significant effect on plaque pH recovery after the intake of both analgesics as min pH, ΔpH, and area under baseline pH were similar to 10% sucrose except for min pH of ibuprofen + water (P = 0.048). However, plaque pH variables after chewing SF gum for 20 min were similar to 10% sorbitol.Conclusion:Chewing SF gum immediately after the intake of sweetened PLAs for 20 min restores plaque pH and could be recommended as a complementary aid in caries prevention.

Evaluation of the Erosive and Cariogenic Potential of Over-the-Counter Pediatric Liquid Analgesics and Antipyretics

“…All the evaluated analgesics and antipyretics had a pH range of 3.40–5.38, which is in the critical pH range (<5.5) for enamel demineralization ( Table 2 ). The results were consistent with previous studies showing that most pediatric liquid medicines had acidic pHs [ 20 , 21 ]. This is expected because of the addition of citric acid to the analgesics and antipyretics ( Table 1 ), which has a pH of 2.2 at 0.1 N and can cause dental erosion following long-term intake of such oral suspensions; citric acid increases enamel solubility owing to its ability to chelate calcium in the hydroxyapatite [ 22 ].…”

Knowledge, attitude, and practice of pediatricians regarding pediatric liquid medicaments

“…It is also available in low-cost, nonhygroscopic and can be easily processed. [69] The medicines that have sucrose as sweetening agent also possess high viscosity and can be readily fermented by oral acidogenic bacteria. Furthermore, these PLM have slow salivary clearance rate and high cariogenic potential.…”

Anticariogenic potential of white cheese, xylitol chewing gum, and black tea

“…Plaque pH was determined by the sampling method. [ 22 ] On each test session, a sample of approximately 1 mg of plaque was obtained from the buccal surfaces of the participant's first permanent molars using a sterile excavator, mixed with 50 μL of distilled water, and the resting pH was measured ex vivo using a microelectrode (Perphect™ Ross™ 8220BN, Thermo Scientific, USA) which had been previously calibrated with pH 7 and pH 4 buffer solutions.…”