Effect of Dietary Copper, Iron and Ascorbic Acid Levels on Hematology, Blood and Tissue Copper, Iron and Zinc Concentrations and 64Cu and 59Fe Metabolism in Young Pigs

Gipp, W. F.; Pond, Wilson G.; Kallfelz, Francis A.; Tasker, John B.; Campen, Darrell R. Van; Krook, L; Visek, Willard J.

doi:10.1093/jn/104.5.532

Cited by 44 publications

(15 citation statements)

References 13 publications

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“…The addition of Fe to the diet had no effect (P > .l) on ADG or ADFI during the 28-d trial. These results are similar to those reported by Hedges and Komegay (1973) Gipp et al (1974). Hematocrit levels were not affected (P > .l) by the addition of 250 ppm of Cu to the diet.…”

Section: Resultssupporting

confidence: 92%

“…By d 28, pigs had adjusted to their high levels of Cu, and the addition of 250 ppm of Cu had no effect (P > .l) on hemoglobin levels. Gipp et al (1974), using similarly aged pigs, reported that on d 35 of their study hemoglobin and packed cell volume were decreased by the addition of 250 ppm of Cu. Pigs in our study may have adjusted to their high dietary Cu levels due to differences in the dietary protein and mineral levels.…”

Section: Resultsmentioning

confidence: 98%

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The effect of copper addition to diets with various iron levels on the performance and hematology of weanling swine

Dove

Haydon

1991

Journal of Animal Science

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A 2 x 6 factorial experiment with Cu added at 5 or 250 ppm and Fe added at 50, 100, 150, 200, 250, or 300 ppm was conducted using 480 crossbred weanling pigs with an average initial weight of 7.0 kg. The basal corn-soybean meal-whey diet contained 4 ppm Cu, 169 ppm Fe, and 199 ppm Zn. Pigs were allotted by weight, sex, and litter outcome group and had ad libitum access to feed and water during the 28-d trials. Animals were weighed and pen feed intake was recorded weekly. Blood samples were collected on d 1, 14, and 28 of the experiment. The addition of 250 ppm Cu increased ADG (P less than .001) and average daily feed intake (ADFI, P less than .01) during the 28-d trials. The addition of Fe had no effect on ADG and ADFI (P greater than .10). A Cu x Fe interaction (P less than .01) was observed for feed/gain. Increasing Fe levels linearly improved hematocrit status (P less than .05) on d 28 of the trial. A Cu x Fe interaction (P less than .08) was observed for hemoglobin at the end of the trial; hemoglobin levels were increased by the addition of Fe to the diet containing 250 ppm of Cu. Plasma Cu was increased (P less than .001) by the addition of 250 ppm of Cu. Plasma Fe was low when either 50 or 100 ppm of Fe was added in the presence of 250 ppm of Cu, but it was not affected at other levels, resulting in a Cu x Fe interaction (P less than .05). These data indicate that levels of added Fe up to 300 ppm may help to improve the hematological status of weanling pigs fed growth-promoting levels of Cu but that it has little effect on performance.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 98%

The effect of copper addition to diets with various iron levels on the performance and hematology of weanling swine

Dove

Haydon

1991

Journal of Animal Science

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“…Vitamin C deficiency in mammals has been reported to disturb iron metabolism by its defective absorption (Van Campen 1972;Gipp, Pond, Kallfelz, Tasker, Van Campen, Krook & Visek 1974;Monsen & Page 1978), transfer of plasma to ferritin (Mazur 1961), distribution of the ferritin itself (Lipschitz, Bothwell, Seftel, Wapnick & Charlton 1971), and impaired release of iron from reticuloendothelial stores (Bothwell, Bradlow, Jacobs, Keeley, Kramer, Seftel & Lail 1964). As mentioned above, disturbed iron metabolism in a scorbutic fish, rainbow trout, has also been reported by Hilton et al (1978) who remarked, however, that it is difficult to state what type of anaemia is present.…”

Section: Discussionmentioning

confidence: 92%

Nutritional deficiency disease in an Indian major carp, Cirrhina mrigala Hamilton, due to avitaminosis C during early growth

Agrawal

Mahajan

1980

Journal of Fish Diseases

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Experiments with a purified vitamin test diet on newly hatched Cirrhina mrigala Hamilton, a major carp of great piscicultural importance, are reported. Experimentally induced vitamin C deficiency for 330 days was followed by recovery treatment for 30 days. Retarded growth and greater mortality accompanied by structural deformities such as lordosis and scoliosis, increasing with prolonged deficiency, were recorded. Haematological and haematopoietic studies revealed hypochromic macrocytic anaemia accompanied by anisocytosis. Correlated studies on er5i;hropoiesis revealed increased reticulocytes and an overall decrease in small lymphoid haemoblasts. Total and differential leucocyte counts revealed leucopenia and thrombopenia accompanied by an increase in neutrophils and eosinophils. Recovery treatment halted and in some cases even compensated these pathophysiological changes to some extent.

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“…Ascorbic acid is a potent inhibitor of Cu absorption in mammals [10] and can reduce the toxicity of dietary Cu to pigs [11]. In fish, dietary ascorbic acid has been shown to decrease the uptake of waterborne Cu in carp [12] and rainbow trout [13].…”

Section: Introductionmentioning

confidence: 99%

Increase of dietary vitamin C improves haemocyte respiratory burst response and growth of juvenile grass shrimp,Penaeus monodon , fed with high dietary copper

Lee

Shiau

2003

Fish & Shellfish Immunology

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Effect of Dietary Copper, Iron and Ascorbic Acid Levels on Hematology, Blood and Tissue Copper, Iron and Zinc Concentrations and 64Cu and 59Fe Metabolism in Young Pigs

Cited by 44 publications

References 13 publications

The effect of copper addition to diets with various iron levels on the performance and hematology of weanling swine

The effect of copper addition to diets with various iron levels on the performance and hematology of weanling swine

Nutritional deficiency disease in an Indian major carp, Cirrhina mrigala Hamilton, due to avitaminosis C during early growth

Increase of dietary vitamin C improves haemocyte respiratory burst response and growth of juvenile grass shrimp,Penaeus monodon , fed with high dietary copper

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