Effect of Dietary Curcumin on the Antioxidant Status of Laying Hens under High-Temperature Conditions

Abstract

Heat stress induces oxidative stress, and reduces body antioxidant metabolite levels, which can affect poultry production performance. Dietary antioxidants protect birds against the adverse effects of heat stress. The effects of increasing concentrations of dietary curcumin on the antioxidant parameters of layers maintained under high-temperature conditions for nine weeks were evaluated. Roman laying hens (n = 336, 22 weeks old, 1420 g BW) were divided into three treatment groups. The first group served as a thermoneutral control (kept at 25 ± 1 °C). The second group was exposed to high temperatures (32 ± 1 °C, 6 h/d), given a basal diet. The third group was further divided into five treatment groups (100, 150, 200, 250, 300 mg/kg Curcumin) fed a basal diet (treatments H1, H2, H3, H4, H5) under high temperatures conditions (32 ± 1 °C, 6 hours/day). As a result of this study, total superoxide dismutase activity was significantly higher in H2 and H3 groups, and total antioxidant capacity was higher in H2, H3, and H5 groups. Catalase and glutathione peroxidase activity was significantly higher in the H3 group. Malondialdehyde concentration was lowered in curcumin supplemented hens compared with control groups hens. Laying hens in all curcumin treatment groups had slightly higher activities of CAT, SOD, GSH-Px, and T-AOC in the liver, heart, and lungs, compared with heat stressed control group. It was concluded that dietary curcumin given to laying hens under heat stress may enhance their antioxidant status, and alleviate the detrimental effects of stressful environmental conditions.

Evaluation of the growth performance, physiological traits, antioxidant indices, and heat shock protein 70 to dietary supplementation of stinging nettle (Urtica dioica) in broilers exposed to chronic heat stress

“…As shown in Table 3, chronic heat stress in the HS group decreased significantly the serum levels of T-AOC, SOD, and GSH-Px activity compared to the NC on day 29. In accordance with these results, Nawab et al (2019) stated that the levels of T-OAC, SOD, and GSH-Px reduced in heat-stressed broilers compared to those on ambient temperature. Dietary stinging nettle at 2% and 4% significantly increased T-AOC levels in serum, liver, and intestine of the HS-SN2, HS-SN4, SN2, and SN4 compared to the HS on days 29 and 35 (Table 3 and 4).…”

“…Various mechanisms are involved in the body of broilers to neutralize ROS and protect the cells against heat stress-induced oxidative stress, including enzymatic antioxidant systems, such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), and non-enzymatic antioxidant systems, glutathione (GSH) for instance (Lu et al, 2007). It was reported that the activity of body antioxidant systems is not sufficient in birds exposed to chronic heat stress and dietary antioxidant supplementation could be beneficial to mitigate the adverse effects of heat stress-induced oxidative stress (Nawab et al, 2019).…”

“…Various researchers have employed different dietary antioxidants for attenuating harmful effects of heat stress on poultry (Toghyani et al, 2011; Nawab et al, 2019). In the recent years, the use of antioxidant-rich plants as feed additives in the broiler diet has also gained popularity among researchers owing to their various pharmacological and beneficial effects on health, oxidant status, and productive performance of broilers (Akbarian et al, 2016).…”

Effect of Dietary Supplementation of Biological Curcumin Nanoparticles on Growth and Carcass Traits, Antioxidant Status, Immunity and Caecal Microbiota of Japanese Quails

“…As a result, dietary curcumin reduces the production of reactive free radicals, leading to an increase in the antioxidant metabolites concentration in the poultry body. The inclusion of curcumin in the diet decreased the malondialdehyde concentration and boosted the activities of CAT, T-AOC, SOD, and GSH-Px compared to the control group [53]. Thus, curcumin can alleviate the negative impact of any stressful environmental condition.…”

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

“…Moreover, CUR can also scavenge superoxide anions (O 2 − ) and hydroxyl radicals (OH − ), and upregulate the expression of genes encoding for antioxidant proteins, such as catalase (CAT), heme oxygenase-1 (HO-1) and superoxide dismutase (SOD) [94,95]. In the brain, CUR can stabilize antioxidant enzymes, including SOD, glutathione peroxidase (GPx), glutathione S-transferase (GST) and protect for radical-induced DNA damages in neuronal cells [96,97].…”