Effect of dietary fiber on bioavailability of zinc and copper and histology in rats

Scheibel, M.; Mehta, Tara

doi:10.1016/s0271-5317(85)80021-x

Cited by 15 publications

(3 citation statements)

References 15 publications

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“…Several studies on rats have investigated the effects of various factors on Cu absorption and retention. The effects of naturally occurring Cu complexes (Mills, 1986), protein source (Lo et al 1984), dietary Zn : Cu ratio (Oestreicher & Cousins, 1985) and fibre (Scheibel & Mehta, 1985) on Cu absorption in the rat have been reported. However, there is only one report dealing with the Cu absorption as function of Cu intakes in rats (Stuart & Johnson, 1986).…”

Section: Copper: Diamine Oxidase: Stable Isotopesmentioning

confidence: 99%

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Feillet‐Coudray¹,

Coudray²,

Bayle³

et al. 2000

Br J Nutr

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There is a lack of agreement on index of Cu status and reliable and sensitive biomarkers are still required. The purpose of this present work was to assess in rats the sensitivity of diamine oxidase (DAO) activity, a recently proposed biomarker, to modifications in dietary Cu intake in comparison with other plasma biomarkers of Cu status. We also evaluated the effect of Cu dietary level on Cu and Zn intestinal absorption. Results showed that plasma Cu and plasma caeruloplasmin were significantly decreased at day 8 compared with the control group (7·4 mg Cu/kg diet) while DAO activity was significantly decreased at day 12 of the deficient diet (0·61 mg Cu/kg diet). Cu supplementation (35 mg Cu/kg diet) had no effect on any of the studied biomarkers of Cu status. In Cu-deficient rats plasma Cu and DAO activities were normalized 4 d after return to the control diet while caeruloplasmin was normalized later, at day 11. Apparent absorption values (%) of total Cu or 65Cu isotope were significantly increased in the Cu-deficient rats compared with the other groups and similar in the control and the Cu-supplemented groups. The urinary excretion of total Cu or 65Cu isotope were increased in the Cu-supplemented group compared with the other two groups. Both apparent absorption and urinary excretion of total Zn or 67Zn isotope remained unchanged in the three experimental groups. In conclusion, DAO activity seemed to be less sensitive to Cu deficiency than plasma Cu or caeruloplasmin concentrations. The present study also showed a significant increase in Cu intestinal absorption with dietary Cu restriction but no decrease with Cu supplementation in the rat.

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Section: Copper: Diamine Oxidase: Stable Isotopesmentioning

confidence: 99%

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Feillet‐Coudray¹,

Coudray²,

Bayle³

et al. 2000

Br J Nutr

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“…While Davis et al (1962) found that isolated soybean protein interfered with Cu utilization in rats, Lo et al (1984) reported that Cu was available equally to rats from isolated soy protein and copper carbonate. Dietary fiber did not impair Cu absorption in rats (Scheibel and Mehta, 1985), and neither phytate nor cellulose affected copper absorption by men (Turnlund et al, 1985).…”

mentioning

confidence: 76%

Copper-65 absorption by men fed intrinsically and extrinsically labeled whole wheat bread

Johnson¹,

Lykken²

1988

J. Agric. Food Chem.

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“…In any case, copper and zinc were relatively poorly absorbed, as is common with these comparatively abundant dietary components (Scheibel & Mehta 1985). However, a low diet availability of zinc, such as that of cafeteria-fed fa/fa rats, is easily compensated by stepping up absorption.…”

Section: Discussionmentioning

confidence: 97%

Management of dietary essential metals (iron, copper, zinc, chromium and manganese) by Wistar and Zucker obese rats fed a self-selected high-energy diet

et al. 1994

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The balances and content of essential elements (iron, copper, zinc, chromium and manganese) in the body of Wistar, Zucker lean and Zucker obese rats fed a reference or cafeteria diet from day 30 to 60 after birth have been studied. Intestinal iron absorption compensated for low iron content of the cafeteria diet and the extra needs of growth and fat deposition. It can be assumed that the altered energy regulation processes that afflict the genetically obese rat are not directly related to altered iron metabolism. Obese Zucker rats had lower copper tissue concentrations than lean rats, but when fed a cafeteria diet the differences between Zucker rats strains disappear. This cannot be traced to large differences in diet copper concentration. A low diet availability of zinc--such as that of cafeteria-fed fa/fa rats--is easily compensated for by increasing absorption. So, as a consequence, we can conclude that genetic obesity did not impair zinc absorption. There was no deficit of zinc in any of the groups studied; the rats have enough capacity to extract zinc within a wide range of dietary concentrations. The absorption of dietary chromium was inversely proportional to its concentration. The ability to extract chromium from the diet and the very low urinary losses are a consequence of its scarcity in most dietary items. Despite wide variations in the manganese of the diets, the absorption rates were practically unchanged except for obese rats fed the cafeteria diet. It seems that this low absorptive capacity is enough to supply the rat with the manganese it needs, since a sizeable--but subjected to 8-fold-span variations--proportion is lost in the urine. This alone points towards a considerable excess of manganese in both diets studied. Obesity does not have a significant effect on the abilities to absorb and retain minerals, since these processes were more related to dietary availability. Management of essential metals by obese rats depends whether this condition is genetic or induced by diet. Most of the differences observed can be related to differences in diet concentration, to the excess fat content or different metabolic attitude to use substrates of obese animals. The data presented show that the cafeteria diet used adequately serves the mineral needs of the rat, since the rat adapts its absorbing and retaining strategies to match the dietary availability of these minerals.

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Effect of dietary fiber on bioavailability of zinc and copper and histology in rats

Cited by 15 publications

References 15 publications

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Copper-65 absorption by men fed intrinsically and extrinsically labeled whole wheat bread

Management of dietary essential metals (iron, copper, zinc, chromium and manganese) by Wistar and Zucker obese rats fed a self-selected high-energy diet

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